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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 7
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General Xenobiochemistry

CDDO-9,11-dihydro-trifluoroethyl amide (CDDO-dhTFEA) induces hepatic cytoprotective genes and increases bile flow in rats

Scott A. ReismanReata Pharmaceuticals, Inc. Irving, TX 75063USACorrespondence[email protected]
,
Keith W. WardReata Pharmaceuticals, Inc. Irving, TX 75063USA
,
Curtis D. KlaassenDepartment of Internal Medicine, University of Kansas Medical Center Kansas City, KS 66160USA
&
Colin J. MeyerReata Pharmaceuticals, Inc. Irving, TX 75063USA
Pages 571-578 | Received 14 Oct 2012, Accepted 12 Nov 2012, Published online: 17 Dec 2012

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Mohammad A. Aminzadeh, Scott A. Reisman, Nosratola D. Vaziri, Mahyar Khazaeli, Jun Yuan & Colin J. Meyer. (2014) The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease. Xenobiotica 44:6, pages 570-578.
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Articles from other publishers (9)

Tai-Hsin Tsai, Yu-Feng Su, Cheng-Yu Tsai, Chieh-Hsin Wu, Kuan-Ting Lee & Yi-Chiang Hsu. (2023) RTA dh404 Induces Cell Cycle Arrest, Apoptosis, and Autophagy in Glioblastoma Cells. International Journal of Molecular Sciences 24:4, pages 4006.
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James H. Lewis, Michel Jadoul, Geoffrey A. Block, Melanie P. Chin, Deborah A. Ferguson, Angie Goldsberry, Colin J. Meyer, Megan O’Grady, Pablo E. Pergola, Scott A. Reisman, W. Christian Wigley & Glenn M. Chertow. (2020) Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD. Clinical and Translational Science 14:1, pages 299-309.
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Youcai Zhang, Andrew J. Lickteig, Jing Liu, Iván L. Csanaky & Curtis D. Klaassen. (2020) Effects of ablation and activation of Nrf2 on bile acid homeostasis in male mice. Toxicology and Applied Pharmacology 403, pages 115170.
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Scott A. Reisman, Deborah A. Ferguson, Chun‐Yue I. Lee & Joel W. Proksch. (2020) Omaveloxolone and TX63682 are hepatoprotective in the STAM mouse model of nonalcoholic steatohepatitis. Journal of Biochemical and Molecular Toxicology 34:9.
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Donna D. Zhang & Eli Chapman. (2020) The role of natural products in revealing NRF2 function. Natural Product Reports 37:6, pages 797-826.
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Dongwei Xu, Lili Chen, Xiaosong Chen, Yankai Wen, Chang Yu, Jufang Yao, Hailong Wu, Xin Wang, Qiang Xia & Xiaoni Kong. (2017) The triterpenoid CDDO-imidazolide ameliorates mouse liver ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy. Cell Death & Disease 8:8, pages e2983-e2983.
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Bryan J. Mathis & Taixing Cui. 2016. Drug Discovery from Mother Nature. Drug Discovery from Mother Nature 291 314 .
Scott A. Reisman, Angela R. Goldsberry, Chun-Yue I. Lee, Megan L. O’Grady, Joel W. Proksch, Keith W. Ward & Colin J. Meyer. (2015) Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers. BMC Dermatology 15:1.
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Delinda A. Johnson & Jeffrey A. Johnson. (2015) Nrf2—a therapeutic target for the treatment of neurodegenerative diseases. Free Radical Biology and Medicine 88, pages 253-267.
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