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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 7
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Research Article

Evaluation of animal models for intestinal first-pass metabolism of drug candidates to be metabolized by CYP3A enzymes via in vivo and in vitro oxidation of midazolam and triazolam

J. KuzeTsukuba Research Center, Taiho Pharmaceutical CompanyIbaraki, Japan
,
T. MutohTsukuba Research Center, Taiho Pharmaceutical CompanyIbaraki, Japan
,
T. TakenakaTsukuba Research Center, Taiho Pharmaceutical CompanyIbaraki, Japan
,
N. OdaTsukuba Research Center, Taiho Pharmaceutical CompanyIbaraki, Japan
,
N. HaniokaLaboratory of Health Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University OkayamaJapan
&
S. NarimatsuLaboratory of Health Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University OkayamaJapanCorrespondence[email protected]
Pages 598-606 | Received 18 Oct 2012, Accepted 16 Nov 2012, Published online: 03 Jan 2013

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Shweta Padmanabhan, Harbeer Kaur, Abhijith Rao, Ajay Saxena, Yogesh Kumar Gupta, T. Thanga Mariappan & Vinay K. Holenarsipur. (2019) Effect of pretreatment regimens of 1-aminobenzotriazole on metabolism and gastric emptying of probe compounds in rat. Xenobiotica 49:6, pages 646-654.
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Shotaro Uehara, Yuichi Iida, Miyuki Ida-Tanaka, Motohito Goto, Kenji Kawai, Masafumi Yamamoto, Yuichiro Higuchi, Satoshi Ito, Riichi Takahashi, Hidetaka Kamimura, Mamoru Ito, Hiroshi Yamazaki, Mitsuo Oshimura, Yasuhiro Kazuki & Hiroshi Suemizu. (2022) Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism. Scientific Reports 12:1.
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Yiqun Li, Huiting Cao, Mengzhu Liu, Benyong Zhang, Xinlong Zhang, Donglei Shi, Liwei Guo, Jinao Duan, Xueping Zhou, Huaxu Zhu & Qichun Zhang. (2018) Different modulation of Panax notoginseng on the absorption profiling of triptolide and tripterine from Tripterygium wilfordii in rat intestine. Chinese Medicine 13:1.
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Ninad Varkhede, Nita Patel, William Chang, Kenneth Ruterbories & M. Laird Forrest. (2018) A Semi-Physiologically Based Pharmacokinetic Model Describing the Altered Metabolism of Midazolam Due to Inflammation in Mice. Pharmaceutical Research 35:8.
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Andrew Owen & Paul Curley. 2014. Humanized Mice for HIV Research. Humanized Mice for HIV Research 339 360 .

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