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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 8
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Research Article

The volume of distribution is an indicator of poor in vitro–in vivo extrapolation of clearance for acidic drugs in the rat

Anna-Karin Sohlenius-SternbeckDMPK, CNSP iMed, AstraZeneca R&D Södertälje SE-151 85 SödertäljeSwedenCorrespondence[email protected]
,
Urban FagerholmDMPK, CNSP iMed, AstraZeneca R&D Södertälje SE-151 85 SödertäljeSweden
&
Johan BylundDMPK, CNSP iMed, AstraZeneca R&D Södertälje SE-151 85 SödertäljeSweden;Pharmaceutical Biosciences, Uppsala Biomedical Centre, Uppsala University UppsalaSweden
Pages 671-678 | Received 30 Sep 2012, Accepted 30 Nov 2012, Published online: 16 Jan 2013

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