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TF. Plasse, R. Fathi, C. Fehrmann & GA. McComsey. (2023) Upamostat: a serine protease inhibitor for antiviral, gastrointestinal, and anticancer indications. Expert Opinion on Investigational Drugs 0:0, pages 1-9.
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Michel A. Struwe, Axel J. Scheidig & Bernd Clement. (2023) The mitochondrial amidoxime reducing component—from prodrug-activation mechanism to drug-metabolizing enzyme and onward to drug target. Journal of Biological Chemistry 299:11, pages 105306.
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Ylenia Mazzocato, Stefano Perin, Julia Morales-Sanfrutos, Zhanna Romanyuk, Stefano Pluda, Laura Acquasaliente, Giuseppe Borsato, Vincenzo De Filippis, Alessandro Scarso & Alessandro Angelini. (2023) A novel genetically-encoded bicyclic peptide inhibitor of human urokinase-type plasminogen activator with better cross-reactivity toward the murine orthologue. Bioorganic & Medicinal Chemistry 95, pages 117499.
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Bernd Clement & Michel A. Struwe. (2023) The History of mARC. Molecules 28:12, pages 4713.
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Joan Zapiter, Jeffrey R. Harmer, Michel Struwe, Axel Scheidig, Bernd Clement & Paul V. Bernhardt. (2022)
Enzyme Electrode Biosensors for
N
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Naveen Vankadari, Vijayasarathy Ketavarapu, Sasikala Mitnala, Ravikanth Vishnubotla, Duvvur Nageshwar Reddy & Debnath Ghosal. (2022) Structure of Human TMPRSS2 in Complex with SARS-CoV-2 Spike Glycoprotein and Implications for Potential Therapeutics. The Journal of Physical Chemistry Letters, pages 5324-5333.
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S. Cyrus Khojasteh, Harvey Wong, Donglu Zhang & Cornelis E.C.A. HopS. Cyrus Khojasteh, Harvey Wong, Donglu Zhang & Cornelis E.C.A. Hop. 2022. Discovery DMPK Quick Guide. Discovery DMPK Quick Guide
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Patrick Indorf, Christian Kubitza, Axel J. Scheidig, Thomas Kunze & Bernd Clement. (2019) Drug Metabolism by the Mitochondrial Amidoxime Reducing Component (mARC): Rapid Assay and Identification of New Substrates. Journal of Medicinal Chemistry 63:12, pages 6538-6546.
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Ina Lunk, Felix-Alexander Litty, Sven Hennig, Ingrid R. Vetter, Jürke Kotthaus, Karin S. Altmann, Gudrun Ott, Antje Havemeyer, Carmen Carrillo García, Bernd Clement & Dennis Schade. (2019)
Discovery of
N
-(4-Aminobutyl)-
N
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h
DDAH-1)
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Sophia Rixen, Antje Havemeyer, Anita Tyl-Bielicka, Kazimiera Pysniak, Marta Gajewska, Maria Kulecka, Jerzy Ostrowski, Michal Mikula & Bernd Clement. (2019) Mitochondrial amidoxime-reducing component 2 (MARC2) has a significant role in N-reductive activity and energy metabolism. Journal of Biological Chemistry 294:46, pages 17593-17602.
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Olivier Berger, Stéphanie Ortial, Sharon Wein, Séverine Denoyelle, Françoise Bressolle, Thierry Durand, Roger Escale, Henri J. Vial & Yen Vo-Hoang. (2019) Evaluation of amidoxime derivatives as prodrug candidates of potent bis-cationic antimalarials. Bioorganic & Medicinal Chemistry Letters 29:16, pages 2203-2207.
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Changmin Park, Joong Gyu Ha, Seungmok Choi, Eunyoung Kim, Keumhan Noh, Beom Soo Shin & Wonku Kang. (2018) HPLC–MS/MS analysis of mesupron and its application to a pharmacokinetic study in rats. Journal of Pharmaceutical and Biomedical Analysis 150, pages 39-42.
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Luisa B. Maia & José J.G. Moura. 2018. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.
Angel Llamas, Alejandro Chamizo-Ampudia, Manuel Tejada-Jimenez, Aurora Galvan & Emilio Fernandez. (2017) The molybdenum cofactor enzyme mARC: Moonlighting or promiscuous enzyme?. BioFactors 43:4, pages 486-494.
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B. Plitzko, A. Havemeyer, B. Bork, F. Bittner, R. Mendel & B. Clement. (2016) Defining the Role of the NADH-Cytochrome-b5 Reductase 3 in the Mitochondrial Amidoxime Reducing Component Enzyme System. Drug Metabolism and Disposition 44:10, pages 1617-1621.
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Tamara Mirzapoiazova, Nurbek Mambetsariev, Frances E. Lennon, Bolot Mambetsariev, Joshua E. Berlind, Ravi Salgia & Patrick A. Singleton. (2015) HABP2 is a Novel Regulator of Hyaluronan-Mediated Human Lung Cancer Progression. Frontiers in Oncology 5.
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Birte Plitzko, Antje Havemeyer, Thomas Kunze & Bernd Clement. (2015) The Pivotal Role of the Mitochondrial Amidoxime Reducing Component 2 in Protecting Human Cells against Apoptotic Effects of the Base Analog N6-Hydroxylaminopurine. Journal of Biological Chemistry 290:16, pages 10126-10135.
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Luisa B. Maia & José J. G. Moura. (2015) Nitrite reduction by molybdoenzymes: a new class of nitric oxide-forming nitrite reductases. JBIC Journal of Biological Inorganic Chemistry 20:2, pages 403-433.
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Gudrun Ott, Antje Havemeyer & Bernd Clement. (2014) The mammalian molybdenum enzymes of mARC. JBIC Journal of Biological Inorganic Chemistry 20:2, pages 265-275.
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Eva Bauch, Debora Reichmann, Ralf-Rainer Mendel, Florian Bittner, Anne-Marie Manke, Philipp Kurz, Ulrich Girreser, Antje Havemeyer & Bernd Clement. (2015)
Electrochemical and mARC-Catalyzed Enzymatic Reduction of
para
-Substituted Benzamidoximes: Consequences for the Prodrug Concept “Amidoximes instead of Amidines”
. ChemMedChem 10:2, pages 360-367.
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Rami A. Al-Horani & Umesh R. Desai. (2014) Recent Advances on Plasmin Inhibitors for the Treatment of Fibrinolysis-Related Disorders. Medicinal Research Reviews 34:6, pages 1168-1216.
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Gudrun Ott, Birte Plitzko, Carmen Krischkowski, Debora Reichmann, Florian Bittner, Ralf R. Mendel, Thomas Kunze, Bernd Clement & Antje Havemeyer. (2014) Reduction of Sulfamethoxazole Hydroxylamine (SMX-HA) by the Mitochondrial Amidoxime Reducing Component (mARC). Chemical Research in Toxicology 27:10, pages 1687-1695.
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Heyka H. Jakobs, Danilo Froriep, Antje Havemeyer, Ralf R. Mendel, Florian Bittner & Bernd Clement. (2014)
The Mitochondrial Amidoxime Reducing Component (mARC): Involvement in Metabolic Reduction of
N
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N
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. ChemMedChem 9:10, pages 2381-2387.
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Heyka H. Jakobs, Michal Mikula, Antje Havemeyer, Adriana Strzalkowska, Monika Borowa-Chmielak, Artur Dzwonek, Marta Gajewska, Ewa E. Hennig, Jerzy Ostrowski & Bernd Clement. (2014) The N-Reductive System Composed of Mitochondrial Amidoxime Reducing Component (mARC), Cytochrome b5 (CYB5B) and Cytochrome b5 Reductase (CYB5R) Is Regulated by Fasting and High Fat Diet in Mice. PLoS ONE 9:8, pages e105371.
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Gudrun Ott, Debora Reichmann, Cornelia Boerger, Ingolf Cascorbi, Florian Bittner, Ralf-Rainer Mendel, Thomas Kunze, Bernd Clement & Antje Havemeyer. (2014)
Functional Characterization of Protein Variants Encoded by Nonsynonymous Single Nucleotide Polymorphisms in
MARC1
and
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Laura Schwarz, Ulrich Girreser & Bernd Clement. (2014)
Synthesis and Characterization of
para
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N
,
N′-
Dihydroxybenzamidines and Their Derivatives as Model Compounds for a Class of Prodrugs
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Birte Plitzko, Gudrun Ott, Debora Reichmann, Colin J. Henderson, C. Roland Wolf, Ralf Mendel, Florian Bittner, Bernd Clement & Antje Havemeyer. (2013) The Involvement of Mitochondrial Amidoxime Reducing Components 1 and 2 and Mitochondrial Cytochrome b5 in N-Reductive Metabolism in Human Cells. Journal of Biological Chemistry 288:28, pages 20228-20237.
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