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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 12
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Research Article

Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline

Masahiro UtohShin Nippon Biomedical Laboratories, Ltd., Pharmacokinetics and Bioanalysis Center KainanJapan;Showa Pharmaceutical University, Laboratory of Drug Metabolism and Pharmacokinetics MachidaJapan
,
Norie MurayamaShowa Pharmaceutical University, Laboratory of Drug Metabolism and Pharmacokinetics MachidaJapan
,
Yasuhiro UnoShin Nippon Biomedical Laboratories, Ltd., Pharmacokinetics and Bioanalysis Center KainanJapan
,
Yui OnoseShowa Pharmaceutical University, Laboratory of Drug Metabolism and Pharmacokinetics MachidaJapan
,
Shinya HosakaShowa Pharmaceutical University, Laboratory of Drug Metabolism and Pharmacokinetics MachidaJapan
,
Hideki FujinoSchool of Pharmacy, Hyogo University of Health Sciences KobeJapan
,
Makiko ShimizuShowa Pharmaceutical University, Laboratory of Drug Metabolism and Pharmacokinetics MachidaJapan
,
Kazuhide IwasakiShin Nippon Biomedical Laboratories, Ltd., Pharmacokinetics and Bioanalysis Center KainanJapan
&
Hiroshi YamazakiShowa Pharmaceutical University, Laboratory of Drug Metabolism and Pharmacokinetics MachidaJapanCorrespondence[email protected]
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Pages 1037-1042 | Received 01 Mar 2013, Accepted 04 Apr 2013, Published online: 16 May 2013

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Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Takako Suzuki, Masahiro Utoh, Erika Sasaki & Hiroshi Yamazaki. (2016) Caffeine 7-N-demethylation and C-8-oxidation mediated by liver microsomal cytochrome P450 enzymes in common marmosets. Xenobiotica 46:7, pages 573-578.
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Takashi Koyanagi, Yasuharu Nakanishi, Norie Murayama, Yoshiyuki Yamaura, Kanami Ikeda, Koji Yano, Shotaro Uehara, Masahiro Utoh, Soonih Kim, Yasuhiro Uno & Hiroshi Yamazaki. (2015) Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro–in vivo correlation. Xenobiotica 45:4, pages 312-321.
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Articles from other publishers (11)

Yasuhiro Uno, Yutaro Noda, Norie Murayama, Kyoko Tsukiyama-Kohara & Hiroshi Yamazaki. (2023) Novel cytochrome P450 1 (CYP1) genes in tree shrews are expressed and encode functional drug-metabolizing enzymes. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 265, pages 109534.
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Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki & Hiroshi Yamazaki. (2019) Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model. Current Drug Metabolism 20:2, pages 103-113.
Crossref
Masahiro Utoh, Tomonori Miura, Takashi Kusama, Shotaro Uehara, Makiko Shimizu, Yasuhiro Uno & Hiroshi Yamazaki. (2017) Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models . Biopharmaceutics & Drug Disposition 38:7, pages 439-442.
Crossref
H. Yamazaki. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 45 50 .
Yasuhiro Uno, Shotaro Uehara & Hiroshi Yamazaki. (2016) Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes. Biochemical Pharmacology 121, pages 1-7.
Crossref
Kazuhide Iwasaki, Yusuke Kitsugi, Kanami Ikeda, Takahiro Yoshikawa, Shinya Hosaka, Shotaro Uehara, Yasuhiro Uno, Masahiro Utoh & Hiroshi Yamazaki. (2016) In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9 . Biopharmaceutics & Drug Disposition 37:6, pages 379-383.
Crossref
Anthony Zulli, Renee M. Smith, Peter Kubatka, Jan Novak, Yoshio Uehara, Hayley Loftus, Tawar Qaradakhi, Miroslav Pohanka, Nazarii Kobyliak, Angela Zagatina, Jan Klimas, Alan Hayes, Giampiero La Rocca, Miroslav Soucek & Peter Kruzliak. (2016) Caffeine and cardiovascular diseases: critical review of current research. European Journal of Nutrition 55:4, pages 1331-1343.
Crossref
Yasuhiro Uno, Akinori Matsushita, Norie Murayama & Hiroshi Yamazaki. (2015) Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9. Drug Metabolism and Pharmacokinetics 30:1, pages 130-132.
Crossref
Martin Kohlmeier. 2015. Nutrient Metabolism. Nutrient Metabolism 95 110 .
Yasuhiro Uno, Akinori Matsushita, Mitsunori Shukuya, Yasuka Matsumoto, Norie Murayama & Hiroshi Yamazaki. (2014) CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques. Biochemical Pharmacology 91:2, pages 242-248.
Crossref
Hiroshi Yamazaki. 2014. Fifty Years of Cytochrome P450 Research. Fifty Years of Cytochrome P450 Research 293 305 .

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