Pharmacokinetic study in pigs and in vitro metabolic characterization in pig- and human-liver microsomes reveal marked differences in disposition and metabolism of tiletamine and zolazepam (Telazol)

Atul KumarProduct Safety Resources, 2635 University Ave W Suite 195, Saint Paul, MNUSACorrespondence[email protected]

Henry J. MannLeslie Dan Faculty of Pharmacy, University of Toronto Toronto, ONCanada

Rory P. RemmelDepartment of Medicinal ChemistryCorrespondence[email protected]
[email protected]

Greg J. BeilmanDepartment of Surgery, University of Minnesota Minneapolis, MNUSA

Nitin KailaPfizer Groton, CTUSA

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Anneli Ryden, Sheila Fisichella, Gaetano Perchiazzi & Görel Nyman. (2021) Comparison of two injectable anaesthetic techniques on induction and subsequent anaesthesia in pigs. Laboratory Animals 55:6, pages 540-550.
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Zhiheng Zhang, Xueman Du, Hui Bai, Meilun Shen, Xiangying Ma, Rouqian Li, Xiaodi Jin & Li Gao. (2021) Cardiopulmonary (No Ventilation) and Anesthetic Effects of Dexmedetomidine–Tiletamine in Dogs. Frontiers in Veterinary Science 8.
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Anneli Rydén, Marianne Jensen-Waern, Görel Nyman & Lena Olsén. (2021) Physiological and Clinical Responses in Pigs in Relation to Plasma Concentrations during Anesthesia with Dexmedetomidine, Tiletamine, Zolazepam, and Butorphanol. Animals 11:6, pages 1482.
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Christine K. Ellis, Morgan E. Wehtje, Lisa L. Wolfe, Peregrine L. Wolff, Clayton D. Hilton, Mark C. Fisher, Shari Green, Michael P. Glow, Joeseph M. Halseth, Michael J. Lavelle, Nathan P. Snow, Eric H. VanNatta, Jack C. Rhyan, Kurt C. VerCauteren, William R. Lance & Pauline Nol. (2019) Comparison of the efficacy of four drug combinations for immobilization of wild pigs. European Journal of Wildlife Research 65:5.
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Lynn J. Miller, David P. Fetterer, Nicole L. Garza, Matthew G. Lackemeyer, Ginger C. Donnelly, Jesse T. Steffens, Sean A. Van Tongeren, Jimmy O. Fiallos, Joshua L. Moore, Shannon T. Marko, Luis A. Lugo-Roman, Greg Fedewa, Joseph L. DeRisi, Jens H. Kuhn & Scott J. Stahl. (2018) A fixed moderate-dose combination of tiletamine+zolazepam outperforms midazolam in induction of short-term immobilization of ball pythons (Python regius). PLOS ONE 13:10, pages e0199339.
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Tatiana O. Kolesnikova, Sergey L. Khatsko, Vadim A. Shevyrin, Yuri Yu Morzherin & Allan V. Kalueff. (2017) Effects of a non-competitive N-methyl-d-aspartate (NMDA) antagonist, tiletamine, in adult zebrafish. Neurotoxicology and Teratology 59, pages 62-67.
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J.C.M. Lewis, P. Teale, G. Webber, J.W. Sear & P.M. Taylor. (2014) Comparison of tiletamine and zolazepam pharmacokinetics in tigers (Panthera tigris) and leopards (Panthera pardus): Do species differences account for adverse effects in tigers?. The Veterinary Journal 201:3, pages 302-306.
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Pharmacokinetic study in pigs and in vitro metabolic characterization in pig- and human-liver microsomes reveal marked differences in disposition and metabolism of tiletamine and zolazepam (Telazol)

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Pharmacokinetic study in pigs and in vitro metabolic characterization in pig- and human-liver microsomes reveal marked differences in disposition and metabolism of tiletamine and zolazepam (Telazol)

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