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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 4
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Research Article

Risk assessment of drug–drug interactions using hepatocytes suspended in serum during the drug discovery process

Yohei KosugiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited KanagawaJapanCorrespondence[email protected]
,
Hideki HirabayashiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited KanagawaJapan
,
Tomoko IgariDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited KanagawaJapan
,
Yasushi FujiokaDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited KanagawaJapan
,
Teruaki OkudaDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited KanagawaJapan
&
Toshiya MoriwakiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited KanagawaJapan
Pages 336-344 | Received 28 Jun 2013, Accepted 21 Aug 2013, Published online: 27 Sep 2013

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Shinji Iwasaki, Hideki Hirabayashi & Nobuyuki Amano. (2018) Quantitative prediction of the extent of drug–drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes. Xenobiotica 48:8, pages 770-780.
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Articles from other publishers (4)

Suein Choi, Dong-Seok Yim & Soo Hyeon Bae. (2022) Prediction of metabolizing enzyme-mediated clinical drug interactions using in vitro information . Translational and Clinical Pharmacology 30:1, pages 1.
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Chuang Lu & Li Di. (2020) In vitro and in vivo methods to assess pharmacokinetic drug– drug interactions in drug discovery and development . Biopharmaceutics & Drug Disposition 41:1-2, pages 3-31.
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Ia Hultman, Charlotta Vedin, Anna Abrahamsson, Susanne Winiwarter & Malin Darnell. (2016) Use of HμREL Human Coculture System for Prediction of Intrinsic Clearance and Metabolite Formation for Slowly Metabolized Compounds. Molecular Pharmaceutics 13:8, pages 2796-2807.
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Janne T. Backman, Anne M. Filppula, Mikko Niemi & Pertti J. Neuvonen. (2015) Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions. Pharmacological Reviews 68:1, pages 168-241.
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