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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 2
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Review Article

Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid

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Pages 135-145 | Received 19 Aug 2013, Accepted 20 Sep 2013, Published online: 23 Oct 2013

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Jinqiu Rao, Ting Peng, Na Li, Yuan Wang, Caiqin Yan, Kai Wang & Feng Qiu. (2022) Nephrotoxicity induced by natural compounds from herbal medicines – a challenge for clinical application. Critical Reviews in Toxicology 52:9, pages 757-778.
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Zhi-e Fang, Chunyu Wang, Ming Niu, Tingting Liu, Lutong Ren, Qiang Li, Zhiyong Li, Ziying Wei, Li Lin, Wenqing Mu, Yuan Gao, Xiaohe Xiao & Zhaofang Bai. (2022) Integration of Transcriptomic and Metabolomic Data to Compare the Hepatotoxicity of Neonatal and Adult Mice Exposed to Aristolochic Acid I. Frontiers in Genetics 13.
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František Bárta, Alena Dedíková, Michaela Bebová, Šárka Dušková, Jaroslav Mráz, Heinz H. Schmeiser, Volker M. Arlt, Petr Hodek & Marie Stiborová. (2021) Co-Exposure to Aristolochic Acids I and II Increases DNA Adduct Formation Responsible for Aristolochic Acid I-Mediated Carcinogenicity in Rats. International Journal of Molecular Sciences 22:19, pages 10479.
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Slobodan P. Rendic & F. Peter Guengerich. (2021) Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update. Archives of Toxicology 95:2, pages 395-472.
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Alena Dedı́ková, František Bárta, Václav Martínek, Kevin Kotalík, Šárka Dušková, Jaroslav Mráz, Volker Manfred Arlt, Marie Stiborová & Petr Hodek. (2020) In Vivo Metabolism of Aristolochic Acid I and II in Rats Is Influenced by Their Coexposure . Chemical Research in Toxicology 33:11, pages 2804-2818.
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Jarmila Nahálková. (2020) Linking TPPII to the protein interaction and signalling networks. Computational Biology and Chemistry 87, pages 107291.
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Viktoriya S. Sidorenko. 2020. Mechanisms of Genome Protection and Repair. Mechanisms of Genome Protection and Repair 139 166 .
Mateja Sborchia, Hector C. Keun, David H. Phillips & Volker M. Arlt. (2019) The Impact of p53 on Aristolochic Acid I-Induced Gene Expression In Vivo. International Journal of Molecular Sciences 20:24, pages 6155.
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Mateja Sborchia, Eric G. De Prez, Marie-Hélène Antoine, Lucie Bienfait, Radek Indra, Gabriel Valbuena, David H. Phillips, Joëlle L. Nortier, Marie Stiborová, Hector C. Keun & Volker M. Arlt. (2019) The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro. Archives of Toxicology 93:11, pages 3345-3366.
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Y. Kapelyukh, C. J. Henderson, N. Scheer, A. Rode & C. R. Wolf. (2019) Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice. Drug Metabolism and Disposition 47:8, pages 907-918.
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Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang & Xinxin Ding. (2018) P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity. Drug Metabolism and Disposition 46:11, pages 1734-1744.
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Marie Stiborová, Volker M. Arlt & Heinz H. Schmeiser. (2017) DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer. International Journal of Molecular Sciences 18:10, pages 2144.
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Volker M. Arlt, Walter Meinl, Simone Florian, Eszter Nagy, Frantisek Barta, Marlies Thomann, Iveta Mrizova, Annette M. Krais, Maggie Liu, Meirion Richards, Amin Mirza, Klaus Kopka, David H. Phillips, Hansruedi Glatt, Marie Stiborova & Heinz H. Schmeiser. (2016) Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone. Archives of Toxicology 91:4, pages 1957-1975.
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Marie Stiborová, Volker M. Arlt & Heinz H. Schmeiser. (2016) Balkan endemic nephropathy: an update on its aetiology. Archives of Toxicology 90:11, pages 2595-2615.
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Jan Milichovský, František Bárta, Heinz Schmeiser, Volker Arlt, Eva Frei, Marie Stiborová & Václav Martínek. (2016) Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1. International Journal of Molecular Sciences 17:2, pages 213.
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Helena Dračínská, František Bárta, Kateřina Levová, Alena Hudecová, Michaela Moserová, Heinz H. Schmeiser, Klaus Kopka, Eva Frei, Volker M. Arlt & Marie Stiborová. (2016) Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo. Toxicology 344-346, pages 7-18.
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Laura E. Wohak, Annette M. Krais, Jill E. Kucab, Julia Stertmann, Steinar Øvrebø, Albrecht Seidel, David H. Phillips & Volker M. Arlt. (2014) Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism. Archives of Toxicology 90:2, pages 291-304.
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Marie Stiborová, František Bárta, Kateřina Levová, Petr Hodek, Heinz Schmeiser, Volker Arlt & Václav Martínek. (2015) A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches. International Journal of Molecular Sciences 16:11, pages 27561-27575.
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Marie Stiborová, František Bárta, Kateřina Levová, Petr Hodek, Eva Frei, Volker M. Arlt & Heinz H. Schmeiser. (2014) The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats. Archives of Toxicology 89:11, pages 2141-2158.
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Volker M. Arlt, Annette M. Krais, Roger W. Godschalk, Yanira Riffo-Vasquez, Iveta Mrizova, Candice A. Roufosse, Charmaine Corbin, Quan Shi, Eva Frei, Marie Stiborova, Frederik-Jan van Schooten, David H. Phillips & Domenico Spina. (2015) Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[ a ]pyrene . Toxicological Sciences 146:2, pages 213-225.
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Annette M. Krais, Karl-Rudolf Mühlbauer, Jill E. Kucab, Helena Chinbuah, Michael G. Cornelius, Quan-Xiang Wei, Monica Hollstein, David H. Phillips, Volker M. Arlt & Heinz H. Schmeiser. (2015) Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts. Toxicology in Vitro 29:1, pages 34-43.
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Volker M. Arlt, Colin J. Henderson, C. Roland Wolf, Marie Stiborová & David H. Phillips. (2015) The Hepatic Reductase Null (HRN ™ ) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants . Toxicology Research 4:3, pages 548-562.
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Marie Stiborová, Eva Frei, Heinz Schmeiser, Volker Arlt & Václav Martínek. (2014) Mechanisms of Enzyme-Catalyzed Reduction of Two Carcinogenic Nitro-Aromatics, 3-Nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches. International Journal of Molecular Sciences 15:6, pages 10271-10295.
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Abaid Malik, Rosi Bissinger, Salvatrice Calabrò, Caterina Faggio, Kashif Jilani & Florian Lang. (2014) Aristolochic Acid Induced Suicidal Erythrocyte Death. Kidney and Blood Pressure Research 39:5, pages 408-419.
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