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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 8
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Research Article

Effect of commonly used organic solvents on Aldehyde oxidase-mediated Vanillin, Phthalazine and Methotrexate oxidation in human, rat and mouse liver subcellular fractions

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Pages 722-733 | Received 02 Nov 2013, Accepted 27 Jan 2014, Published online: 17 Feb 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Siva Nageswara Rao Gajula, Tanaaz Navin Nathani, Rashmi Madhukar Patil, Sasikala Talari & Rajesh Sonti. (2022) Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development. Drug Metabolism Reviews 54:4, pages 427-448.
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Daigo Asano, Takahiro Shibayama, Hideyuki Shiozawa, Shin-ichi Inoue, Tsuyoshi Shinozuka, Shinji Murata, Nobuaki Watanabe & Kouichi Yoshinari. (2021) Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase. Xenobiotica 51:9, pages 1060-1070.
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Articles from other publishers (8)

Anam Hammid, John K. Fallon, Kati-Sisko Vellonen, Toni Lassila, Mika Reinisalo, Arto Urtti, Francisco Gonzalez, Ari Tolonen, Philip C. Smith & Paavo Honkakoski. (2023) Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues. European Journal of Pharmaceutical Sciences, pages 106603.
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Mengting Huang, Keyun Zhu, Yimeng Wang, Chaofeng Lou, Huimin Sun, Weihua Li, Yun Tang & Guixia Liu. (2023) In Silico Prediction of Metabolic Reaction Catalyzed by Human Aldehyde Oxidase. Metabolites 13:3, pages 449.
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Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
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Wee Kiat Tan, Alyssa Rui Yi Tan, Punitha Sivanandam, Ernest Jing Hui Goh, Ze Ping Yap, Nur Fazilah Saburulla, Karl Austin-Muttitt, Jonathan G.L. Mullins & Aik Jiang Lau. (2020) In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate. Journal of Pharmacology and Experimental Therapeutics 374:2, pages 295-307.
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Lei Zhou, Xiao-yan Pang, Xiang-yu Hou, Lu Liu, Zi-tao Guo & Xiao-yan Chen. (2020) Nimesulide increases the aldehyde oxidase activity of humans and rats. Acta Pharmacologica Sinica 41:6, pages 843-851.
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Shiyan Chen, Karl Austin-Muttitt, Linghua Harris Zhang, Jonathan G. L. Mullins & Aik Jiang Lau. (2019) In Vitro and In Silico Analyses of the Inhibition of Human Aldehyde Oxidase by Bazedoxifene, Lasofoxifene, and Structural Analogues. Journal of Pharmacology and Experimental Therapeutics 371:1, pages 75-86.
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Jiarong Xie, Nur Fazilah Saburulla, Shiyan Chen, Siew Ying Wong, Ze Ping Yap, Linghua Harris Zhang & Aik Jiang Lau. (2019) Evaluation of Carbazeran 4-Oxidation and O 6 -Benzylguanine 8-Oxidation as Catalytic Markers of Human Aldehyde Oxidase: Impact of Cytosolic Contamination of Liver Microsomes . Drug Metabolism and Disposition 47:1, pages 26-37.
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Nenad Manevski, Kamal Kumar Balavenkatraman, Barbara Bertschi, Piet Swart, Markus Walles, Gian Camenisch, Hilmar Schiller, Olivier Kretz, Barbara Ling, Reto Wettstein, Dirk J. Schaefer, Francois Pognan, Armin Wolf & Karine Litherland. (2014) Aldehyde Oxidase Activity in Fresh Human Skin. Drug Metabolism and Disposition 42:12, pages 2049-2057.
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