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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 12
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Animal Pharmacokinetics and Metabolism

Pharmacokinetics and tissue distribution of ginsenoside Rh2 and Rg3 epimers after oral administration of BST204, a purified ginseng dry extract, in rats

Soo Hyeon BaeCollege of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea BucheonRepublic of Korea
,
Jung Bae ParkCollege of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea BucheonRepublic of Korea
,
Yu Fen ZhengCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University SeoulRepublic of Korea
,
Min Jung JangGreen Cross Health Science Co., Ltd SungnamRepublic of Korea
,
Sun Ok KimGreen Cross Health Science Co., Ltd SungnamRepublic of Korea
,
Jeom Yong KimGreen Cross Health Science Co., Ltd SungnamRepublic of Korea
,
Young Hyo YooGreen Cross Health Science Co., Ltd SungnamRepublic of Korea
,
Kee Dong YoonCollege of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea BucheonRepublic of Korea
,
Euichaul OhCollege of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea BucheonRepublic of Korea
&
Soo Kyung BaeCollege of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea BucheonRepublic of KoreaCorrespondence[email protected]
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Pages 1099-1107 | Received 21 Apr 2014, Accepted 26 May 2014, Published online: 16 Jun 2014

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Soo Min Jang, Soo Hyeon Bae, Woong-Kee Choi, Jung Bae Park, Doyun Kim, Jee Sun Min, Hunseung Yoo, Minseok Kang, Keun Ho Ryu & Soo Kyung Bae. (2015) Pharmacokinetic properties of trifolirhizin, (–)-maackiain, (–)-sophoranone and 2-(2,4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran after intravenous and oral administration of Sophora tonkinensis extract in rats. Xenobiotica 45:12, pages 1092-1104.
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Articles from other publishers (23)

Qi-rui Hu, Huan Hong, Zhi-hong Zhang, Hua Feng, Ting Luo, Jing Li, Ze-yuan Deng & Fang Chen. (2023) Methods on improvements of the poor oral bioavailability of ginsenosides: Pre-processing, structural modification, drug combination, and micro- or nano- delivery system. Journal of Ginseng Research 47:6, pages 694-705.
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Rui-yuan Jiang, Zi-ru Fang, Huan-ping Zhang, Jun-yao Xu, Jia-yu Zhu, Ke-yu Chen, Wei Wang, Xiao Jiang & Xiao-jia Wang. (2023) Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer. Chinese Medicine 18:1.
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Sung-Won Kim, Byung-Cheol Han, Seung-Ho So, Chang-Kyun Han, Gyo In, Chae-Kyu Park & Sun Hee Hyun. (2023) Biodistribution and pharmacokinetic evaluation of Korean Red Ginseng components using radioisotopes in a rat model. Journal of Ginseng Research 47:1, pages 74-80.
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Fei Li, Xin Sui, Renwen Zhang, Qiuting Huang & Ying Xie. (2022) Ginsenoside Rg3 attenuates fat accumulation in zebrafish with high-fat-diet-induced obesity. Pharmacological Research - Modern Chinese Medicine 2, pages 100041.
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Meng Zhang, Yang Yi, Bai‐Han Gao, Hui‐Fei Su, Yang‐Oujie Bao, Xiao‐Meng Shi, Hai‐Dong Wang, Fu‐Dong Li, Min Ye & Xue Qiao. (2021) Functional Characterization and Protein Engineering of a Triterpene 3‐/6‐/2′‐ O ‐Glycosyltransferase Reveal a Conserved Residue Critical for the Regiospecificity . Angewandte Chemie International Edition 61:8.
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Meng Zhang, Yang Yi, Bai‐Han Gao, Hui‐Fei Su, Yang‐Oujie Bao, Xiao‐Meng Shi, Hai‐Dong Wang, Fu‐Dong Li, Min Ye & Xue Qiao. (2021) Functional Characterization and Protein Engineering of a Triterpene 3‐/6‐/2′‐ O ‐Glycosyltransferase Reveal a Conserved Residue Critical for the Regiospecificity . Angewandte Chemie 134:8.
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Xin-Ling He, Xiao-Huang Xu, Jia-Jie Shi, Mingqing Huang, Yitao Wang, Xiuping Chen & Jin-Jian Lu. (2021) Anticancer Effects of Ginsenoside Rh2: A Systematic Review. Current Molecular Pharmacology 15:1, pages 179-189.
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Yan Xu, Jinhang Li, Yanhong Shi, Li Yang, Zhengtao Wang, Han Han & Rui Wang. (2020) Stereoselective pharmacokinetic study of epiprogoitrin and progoitrin in rats with UHPLC–MS/MS method. Journal of Pharmaceutical and Biomedical Analysis 187, pages 113356.
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Linggai Cao, Hao Wu, He Zhang, Quan Zhao, Xue Yin, Dongran Zheng, Chuanwang Li, Min‐Jun Kim, Pyol Kim, Zheyong Xue, Yu Wang & Yuhua Li. (2020) Highly efficient production of diverse rare ginsenosides using combinatorial biotechnology. Biotechnology and Bioengineering 117:6, pages 1615-1627.
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Yan Zhang, Shuang Wang, Shuang Song, Xiaomei Yang & Gang Jin. (2020) Ginsenoside Rg3 Alleviates Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Mice by Regulating CD4 + CD25 + Foxp3 + Treg Cells . Journal of Agricultural and Food Chemistry 68:17, pages 4893-4902.
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Dan Hu, Hao Gao & Xin-sheng Yao. 2020. Comprehensive Natural Products III. Comprehensive Natural Products III 577 612 .
Huayu Yan, Huding Jin, Yu Fu, Zhenxing Yin & Chengri Yin. (2019) Production of Rare Ginsenosides Rg3 and Rh2 by Endophytic Bacteria from Panax ginseng . Journal of Agricultural and Food Chemistry 67:31, pages 8493-8499.
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Lei Zhang, Xiao-Yan Liu, Wei Xu & Xiu-Wei Yang. (2019) Pharmacokinetics comparison of 15 ginsenosides and 3 aglycones in Ginseng Radix et Rhizoma and Baoyuan decoction using ultra-fast liquid chromatography coupled with triple quadrupole tandem mass spectrometry. Phytomedicine 59, pages 152775.
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Heebin Son, Keumhan Noh, InWha Park, MinKyun Na, Sangtaek Oh, Beom Shin & Wonku Kang. (2019) Stereo-Selective Pharmacokinetics of Ilimaquinone Epimers Extracted from a Marine Sponge in Rats. Marine Drugs 17:3, pages 171.
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Maryam Nakhjavani, Jennifer E Hardingham, Helen M Palethorpe, Yoko Tomita, Eric Smith, Tim J Price & Amanda R Townsend. (2019) Ginsenoside Rg3: Potential Molecular Targets and Therapeutic Indication in Metastatic Breast Cancer. Medicines 6:1, pages 17.
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Longyun Zhang, Lijuan Zhang, Xiaoyong Wang & Hongwei Si. (2017) Anti-adipogenic Effects and Mechanisms of Ginsenoside Rg3 in Pre-adipocytes and Obese Mice. Frontiers in Pharmacology 8.
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Nan Shao, Huan Jiang, Xiaotong Wang, Bo Yuan, Yi Jin, Mantong Song, Yuqing Zhao & Haiyan Xu. (2017) Stereoselective pharmacokinetics of 25-methoxyl-dammarane-3β,12β,20-triol and its active demethyl-metabolite epimers in rats after oral and intravenous administration. Fitoterapia 116, pages 139-145.
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Doyun Kim, Yu Fen Zheng, Jee Sun Min, Jung Bae Park, Soo Hyeon Bae, Kee Dong Yoon, Young-Won Chin, Euichaul Oh & Soo Kyung Bae. (2016) In vitro stereoselective inhibition of ginsenosides toward UDP-glucuronosyltransferase (UGT) isoforms. Toxicology Letters 259, pages 1-10.
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Shanshan Song, Peixu Cong, Jie Xu, Guoyun Li, Xiaofang Liu, Zhaojie Li, Changhu Xue, Yong Xue & Yuming Wang. (2016) Absorption and pharmacokinetic study of two sulphated triterpenoid saponins in rat after oral and intravenous administration of saponin extracts of Pearsonothuria graeffei by HPLC-MS. Journal of Functional Foods 25, pages 62-69.
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Ming Peng, Xiaonan Li, Tong Zhang, Yue Ding, Yaxiong Yi, Jian Le, Yongjian Yang & Xijing Chen. (2016) Stereoselective pharmacokinetic and metabolism studies of 20(S)- and 20(R)-ginsenoside Rg3 epimers in rat plasma by liquid chromatography-electrospray ionization mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 121, pages 215-224.
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An-Sik Chung & Kyeong Mee Park. 2016. 131 158 .
Pingping Wang, Yongjun Wei, Yun Fan, Qunfang Liu, Wei Wei, Chengshuai Yang, Lei Zhang, Guoping Zhao, Jianmin Yue, Xing Yan & Zhihua Zhou. (2015) Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts. Metabolic Engineering 29, pages 97-105.
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Qiujun Guo, Jie Li & Hongsheng Lin. (2015) Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Immunosuppressive Microenvironment. BioMed Research International 2015, pages 1-12.
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