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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 12
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Research Article

Pharmacokinetics and disposition of dalcetrapib in rats and monkeys

Hiroaki TakuboDrug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. OsakaJapanCorrespondence[email protected]
,
Tomohiro IshikawaClinical Research Planning Department, Pharmaceutical Division, Japan Tobacco Inc., Tokyo, Japan
,
Olaf KuhlmannNon-Clinical Drug Safety, Pharma Research and Early Development, F. Hoffmann-La Roche Ltd. BaselSwitzerland
,
Hiroyuki NemotoSekisui Medical Co., Ltd.Tokyo, Japan
,
Tomoyuki NoguchiSekisui Medical Co., Ltd.Tokyo, Japan
,
Toyomichi NanayamaDrug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. OsakaJapan
,
Hiroshi KomuraDrug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. OsakaJapan
&
Motohiro KogayuDrug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc. OsakaJapan
 show all
Pages 1117-1126 | Received 13 Apr 2014, Accepted 04 Jun 2014, Published online: 23 Jun 2014

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Hiroaki Takubo, Tomohiro Ishikawa, Toshio Taniguchi, Kazunori Iwanaga & Yukihiro Nomura. (2021) The influence of multiple oral administration on the pharmacokinetics and distribution profile of dalcetrapib in rats. Xenobiotica 51:1, pages 82-87.
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Hiroaki Takubo, Toshio Taniguchi, Kazunori Iwanaga & Yukihiro Nomura. (2021) Evaluation of the changes in exposure to thiol compounds in chronic kidney disease patients using the PBPK model. Xenobiotica 51:1, pages 31-39.
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Articles from other publishers (3)

Jasmine Phénix, Jonathan Côté, Denis Dieme, Sherilyn J. Recinto, Felix Oestereich, Sasen Efrem, Sami Haddad, Michèle Bouchard & Lisa Marie Munter. (2023) CETP inhibitor evacetrapib enters mouse brain tissue. Frontiers in Pharmacology 14.
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Eric J Niesor, Guy Boivin, Eric Rhéaume, Rong Shi, Véronique Lavoie, Nathalie Goyette, Marie-Eve Picard, Anne Perez, Fouzia Laghrissi-Thode & Jean-Claude Tardif. (2021) Inhibition of the 3CL Protease and SARS-CoV-2 Replication by Dalcetrapib. ACS Omega 6:25, pages 16584-16591.
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Mathieu R. Brodeur, David Rhainds, Daniel Charpentier, Teodora Mihalache-Avram, Mélanie Mecteau, Geneviève Brand, Evelyne Chaput, Anne Perez, Eric J. Niesor, Eric Rhéaume, Cyrille Maugeais & Jean-Claude Tardif. (2017) Dalcetrapib and anacetrapib differently impact HDL structure and function in rabbits and monkeys. Journal of Lipid Research 58:7, pages 1282-1291.
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