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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 1
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Research Article

Glucuronidation of fimasartan, a new angiotensin receptor antagonist, is mainly mediated by UGT1A3

Eun-Sook JeongDepartment of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Korea,
,
Yang-Weon KimDepartment of Emergency Medicine, Inje University Busan Paik Hospital, Busan, Korea,
,
Hyo-Ji KimDepartment of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Korea,
,
Ho-Jung ShinDepartment of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Korea,
,
Jae-Gook ShinDepartment of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Korea,
,
Kwang Hee KimDepartment of General Surgery, Inje University Busan Paik Hospital, Busan, Korea, and
,
Yong Ha ChiCentral Research Institute, Boryung Pharm. Co., Ltd., Seoul, South Korea
,
Soo Heui PaikCentral Research Institute, Boryung Pharm. Co., Ltd., Seoul, South Korea
&
Dong-Hyun KimDepartment of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Korea, Correspondence[email protected]
 show all
Pages 10-18 | Received 13 May 2014, Accepted 05 Jul 2014, Published online: 18 Jul 2014

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Su-Nyeong Jang, So-Young Park, Hyunyoung Lee, Hyojin Jeong, Ji-Hyeon Jeon, Im-Sook Song, Mi Jeong Kwon & Kwang-Hyeon Liu. (2021) In vitro modulatory effects of ginsenoside compound K, 20(S)-protopanaxadiol and 20(S)-protopanaxatriol on uridine 5′-diphospho-glucuronosyltransferase activity and expression. Xenobiotica 51:10, pages 1087-1094.
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Woo Youl Kang, Hae Won Lee, Mi-Ri Gwon, Seungil Cho, Wang-Seob Shim, Kyung-Tae Lee, Dong Heon Yang, Sook Jin Seong & Young-Ran Yoon. (2020) A Pharmacokinetic Drug Interaction Between Fimasartan and Linagliptin in Healthy Volunteers. Drug Design, Development and Therapy 14, pages 2101-2111.
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Yewon Choi, SeungHwan Lee, In-Jin Jang & Kyung-Sang Yu. (2018) Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers. Drug Design, Development and Therapy 12, pages 2301-2309.
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Woo Youl Kang, Sook Jin Seong, Boram Ohk, Mi-Ri Gwon, Bo Kyung Kim, Seungil Cho, Wang-Seob Shim, Kyung-Tae Lee, Eun Hee Kim, Dong Heon Yang, Hae Won Lee & Young-Ran Yoon. (2018) Pharmacokinetic and bioequivalence study comparing a fimasartan/rosuvastatin fixed-dose combination with the concomitant administration of fimasartan and rosuvastatin in healthy subjects. Drug Design, Development and Therapy 12, pages 3607-3615.
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Ji-Yoon Lee, Young Jae Choi, Soo Jin Oh, Yong Ha Chi, Soo Heui Paik, Ki Ho Lee, Jae-Kyung Jung, Chang Seon Ryu, Kwon-Bok Kim, Dong-Hyun Kim, Young-Ran Yoon & Sang Kyum Kim. (2016) Characterization of fimasartan metabolites in human liver microsomes and human plasma. Xenobiotica 46:1, pages 40-51.
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Zhufeng Wu, Xingwang Zhang, Zhiguo Ma & Baojian Wu. (2015) Establishment of pharmacophore and VolSurf models to predict the substrates of UDP-glucuronosyltransferase1A3. Xenobiotica 45:8, pages 653-662.
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Rui Gao, Mingyi Liu, Yu Chen, Chunhua Xia, Hong Zhang, Yuqing Xiong & Shibo Huang. (2016) Identification and characterization of human UDP-glucuronosyltransferases responsible for the in?vitro glucuronidation of ursolic acid. Drug Metabolism and Pharmacokinetics 31:4, pages 261-268.
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Hae-Young Lee & Byung-Hee Oh. (2016) Fimasartan: A New Angiotensin Receptor Blocker. Drugs 76:10, pages 1015-1022.
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Jong-Lyul Ghim, Soo Heui Paik, M. Hasanuzzaman, Yong Ha Chi, Hyang-Ki Choi, Dong-Hyun Kim & Jae-Gook Shin. (2016) Absolute bioavailability and pharmacokinetics of the angiotensin II receptor antagonist fimasartan in healthy subjects. The Journal of Clinical Pharmacology 56:5, pages 576-580.
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Zofia Mazerska, Anna Mróz, Monika Pawłowska & Ewa Augustin. (2016) The role of glucuronidation in drug resistance. Pharmacology & Therapeutics 159, pages 35-55.
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