Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 1
Submit an article Journal homepage
387
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Semi-physiological pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of 5-fluorouracil for thrombocytopenia in rats

Shinji KobuchiDepartment of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan,
,
Yukako ItoDepartment of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan, Correspondence[email protected]
,
Taro HayakawaDepartment of Pharmacy, Otsu Municipal Hospital, Otsu, Shiga, Japan,
,
Asako NishimuraDepartment of Biopharmaceutics, Doshisha Women’s College of Liberal Arts, Kyotanabe, Kyoto, Japan, and
,
Nobuhito ShibataDepartment of Biopharmaceutics, Doshisha Women’s College of Liberal Arts, Kyotanabe, Kyoto, Japan, and
,
Kanji TakadaBioSerenTach Inc., Shimogyo-ku, Kyoto, Japan
&
Toshiyuki SakaedaDepartment of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan,
show all
Pages 19-28 | Received 06 Jun 2014, Accepted 07 Jul 2014, Published online: 22 Jul 2014

Citations (7)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Shinji Kobuchi, Yosuke Katsuyama & Yukako Ito. (2020) Mechanism-based pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of oxaliplatin for hematological toxicity in rats. Xenobiotica 50:2, pages 146-153.
Read now
Shinji Kobuchi, Yukako Ito, Yuya Nakano & Toshiyuki Sakaeda. (2016) Population pharmacokinetic modelling and simulation of 5-fluorouracil incorporating a circadian rhythm in rats. Xenobiotica 46:7, pages 597-604.
Read now

Articles from other publishers (5)

M. I. Airapetov, S. O. Eresko, E. R. Bychkov, A. A. Lebedev & P. D. Shabanov. (2022) Effect of Ethanol on Platelet Biology. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry 16:4, pages 305-317.
Crossref
M.I. Airapetov, S.O. Eresko, E.R. Bychkov, A.A. Lebedev & P.D. Shabanov. (2022) Effect of ethanol on platelet biology. Biomeditsinskaya Khimiya 68:2, pages 81-92.
Crossref
M. Sturrock, I. S. Miller, G. Kang, N. Hannis Arba’ie, A. C. O’Farrell, A. Barat, G. Marston, P. L. Coletta, A. T. Byrne & J. H. Prehn. (2018) Anti-angiogenic drug scheduling optimisation with application to colorectal cancer. Scientific Reports 8:1.
Crossref
Shinji Kobuchi, Yukako Ito & Toshiyuki Sakaeda. (2016) Population Pharmacokinetic–Pharmacodynamic Modeling of 5-Fluorouracil for Toxicities in Rats. European Journal of Drug Metabolism and Pharmacokinetics 42:4, pages 707-718.
Crossref
Wojciech Krzyzanski, Juan Jose Perez-Ruixo & John Harrold. (2015) Pharmacodynamic model for chemoradiotherapy-induced thrombocytopenia in mice. Journal of Pharmacokinetics and Pharmacodynamics 42:6, pages 709-720.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.