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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 2
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Research Article

Mass balance, pharmacokinetics and metabolism of the selective S1P1 receptor modulator ponesimod in humans

Maribel ReyesDepartment of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland and
,
Matthias HochDepartment of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland and Correspondence[email protected]
,
Patrick BrossardDepartment of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland and
,
Winfried Wagner-RedekerSwiss BioAnalytics, Birsfelden, Switzerland
,
Tommaso MiravalSwiss BioAnalytics, Birsfelden, Switzerland
&
Jasper DingemanseDepartment of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland and
Pages 139-149 | Received 30 Jun 2014, Accepted 14 Aug 2014, Published online: 04 Sep 2014

Citations (15)

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Read on this site (2)

Victor Constantinescu, Katja Akgün & Tjalf Ziemssen. (2022) Current status and new developments in sphingosine-1-phosphate receptor antagonism: fingolimod and more. Expert Opinion on Drug Metabolism & Toxicology 18:10, pages 675-693.
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Ranjeet Prasad Dash, Rana Rais & Nuggehally R. Srinivas. (2018) Ponesimod, a selective sphingosine 1-phosphate (S1P1) receptor modulator for autoimmune diseases: review of clinical pharmacokinetics and drug disposition. Xenobiotica 48:5, pages 442-451.
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Articles from other publishers (13)

Terra M. Kruger, Belén Valenzuela, Charles D. Thompson, Sivi Ouwerkerk-Mahadevan & Juan Jose Perez Ruixo. (2023) Clinical Pharmacokinetics of Ponesimod, a Selective S1P1 Receptor Modulator, in the Treatment of Multiple Sclerosis. Clinical Pharmacokinetics 62:11, pages 1533-1550.
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Simon G. Wong & Shuguang Ma. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development 137 174 .
Anthony Markham. (2021) Ponesimod: First Approval. Drugs 81:8, pages 957-962.
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Himanshu Chokhawala, Shyamal C. Bir & Alireza Minagar. 2018. Neuroinflammation. Neuroinflammation 247 259 .
Dominik Lott, Thorsten Lehr, Jasper Dingemanse & Andreas Krause. (2016) Impact of Demographics, Organ Impairment, Disease, Formulation, and Food on the Pharmacokinetics of the Selective S1P1 Receptor Modulator Ponesimod Based on 13 Clinical Studies. Clinical Pharmacokinetics 56:4, pages 395-408.
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Javier Saurina & Sonia Sentellas. (2017) Strategies for metabolite profiling based on liquid chromatography. Journal of Chromatography B 1044-1045, pages 103-111.
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Margaux Boehler, Pierre-Eric Juif, Matthias Hoch & Jasper Dingemanse. (2016) Absolute Bioavailability of Ponesimod, a Selective S1P1 Receptor Modulator, in Healthy Male Subjects. European Journal of Drug Metabolism and Pharmacokinetics 42:1, pages 129-134.
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Dominik Lott, Andreas Krause, Jasper Dingemanse & Thorsten Lehr. (2016) Population pharmacokinetics of ponesimod and its primary metabolites in healthy and organ-impaired subjects. European Journal of Pharmaceutical Sciences 89, pages 83-93.
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Nicolas Guérard, Christian Zwingelstein, Matthias Hoch & Jasper Dingemanse. (2016) Effect of Hepatic or Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of Ponesimod, a Selective S1P 1 Receptor Modulator . Basic & Clinical Pharmacology & Toxicology 118:5, pages 356-368.
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Daniele D’Ambrosio, Mark S. Freedman & Joerg Prinz. (2016) Ponesimod, a selective S1P1 receptor modulator: a potential treatment for multiple sclerosis and other immune-mediated diseases. Therapeutic Advances in Chronic Disease 7:1, pages 18-33.
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Pierre-Eric Juif, Matthias Hoch, Daniele D’Ambrosio & Jasper Dingemanse. (2015) Biocomparison of Three Formulations of the S1P1 Receptor Modulator Ponesimod in Healthy Subjects. Drugs in R&D 15:2, pages 203-210.
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Simon Temple. (2015) Liquid scintillation counting: how has it advanced over the years and what does the future hold?. Bioanalysis 7:5, pages 503-505.
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Maribel Reyes, Matthias Hoch, Patrick Brossard & Jasper Dingemanse. (2014) Effects of Ethnicity and Sex on the Pharmacokinetics and Pharmacodynamics of the Selective Sphingosine-1-Phosphate Receptor 1 Modulator Ponesimod: A Clinical Study in Japanese and Caucasian Subjects. Pharmacology 94:5-6, pages 223-229.
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