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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 4
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Research Article

Species differences and substrate specificity of CYP3A heteroactivation by efavirenz

Yohei KosugiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, JapanCorrespondence[email protected]
&
Junzo TakahashiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
Pages 345-352 | Received 04 Sep 2014, Accepted 24 Oct 2014, Published online: 11 Nov 2014

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Tomohiko Ichikawa, Hirofumi Tsujino, Takahiro Miki, Masaya Kobayashi, Chiaki Matsubara, Sara Miyata, Taku Yamashita, Kohei Takeshita, Yasushige Yonezawa & Tadayuki Uno. (2018) Allosteric activation of cytochrome P450 3A4 by efavirenz facilitates midazolam binding. Xenobiotica 48:12, pages 1227-1236.
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Articles from other publishers (5)

Nai-Rong Liu, Kai Yang, Wen-Ting Li, Zhi-Hua Pang, Qing Zhang, Jia-Jia Wang, Wen-Xi Dang, Ruo-Yong Jia, Zhi-Wei Fu, Yi-Xuan Li, Zhu-Hua Yao & Zhong-Ze Fang. (2020) Evaluation of the inhibition of chlorophenols towards human cytochrome P450 3A4 and differences among various species. Science of The Total Environment 724, pages 138187.
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Mery Giantin, Minna Rahnasto-Rilla, Roberta Tolosi, Lorena Lucatello, Marianna Pauletto, Giorgia Guerra, Francesca Pezzato, Rosa M. Lopparelli, Roberta Merlanti, Paolo Carnier, Francesca Capolongo, Paavo Honkakoski & Mauro Dacasto. (2019) Functional impact of cytochrome P450 3A (CYP3A) missense variants in cattle. Scientific Reports 9:1.
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Yasushi Yamazoe, Takahiro Goto & Masahiro Tohkin. (2019) Reconstitution of CYP3A4 active site through assembly of ligand interactions as a grid-template: Solving the modes of the metabolism and inhibition. Drug Metabolism and Pharmacokinetics 34:2, pages 113-125.
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Rong Shi, Jiasheng Wu, Cong Meng, Bingliang Ma, Tianming Wang, Yuanyuan Li & Yueming Ma. (2016) Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O -glucuronidation increased, in mice with diabetes mellitus . Biopharmaceutics & Drug Disposition 37:7, pages 433-443.
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Rong Shi, Bingliang Ma, Jiasheng Wu, Tianming Wang & Yueming Ma. (2015) Rapid and accurate liquid chromatography and tandem mass spectrometry method for the simultaneous quantification of ten metabolic reactions catalyzed by hepatic cytochrome P450 enzymes. Journal of Separation Science 38:19, pages 3363-3373.
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