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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 9
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General Xenobiochemistry

Improvement bioavailability of silymarin ameliorates severe dyslipidemia associated with metabolic syndrome

Martin PorubaDepartment of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic,
,
Ludmila KazdováCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, and
,
Olena OliyarnykCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, and
,
Hana MalinskáCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, and
,
Zuzana MatuskováDepartment of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic,
,
Igor Tozzi di AngeloDepartment of Internal Medicine II – Gastroenterology and Hepatology, University Hospital Olomouc, Olomouc, Czech RepublicCorrespondence[email protected]
,
Vojtech SkopCenter of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, and
&
Rostislav VeceraDepartment of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic, Correspondence[email protected]
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Pages 751-756 | Received 11 Dec 2014, Accepted 19 Jan 2015, Published online: 11 Jun 2015

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Mahmood Barani, Enrico Sangiovanni, Marco Angarano, Mohammad Amin Rajizadeh, Mehrnaz Mehrabani, Stefano Piazza, Hosahalli Veerabhadrappa Gangadharappa, Abbas Pardakhty, Mehrzad Mehrbani, Mario Dell’Agli & Mohammad Hadi Nematollahi. (2021) Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature. International Journal of Nanomedicine 16, pages 6983-7022.
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Articles from other publishers (15)

Nikolaos P. E. Kadoglou, Chrystalla Panayiotou, Michail Vardas, Nikolaos Balaskas, Nikolaos G. Kostomitsopoulos, Alexandra K. Tsaroucha & Georgia Valsami. (2022) A Comprehensive Review of the Cardiovascular Protective Properties of Silibinin/Silymarin: A New Kid on the Block. Pharmaceuticals 15:5, pages 538.
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Rostislav Vecera, Martin Poruba, Martina Hüttl, Hana Malinska, Olena Oliyarnyk, Irena Markova, Zuzana Racova, Jan Soukop & Ludmila Kazdova. (2022) Beneficial Effect of Fenofibrate and Silymarin on Hepatic Steatosis and Gene Expression of Lipogenic and Cytochrome P450 Enzymes in Non-Obese Hereditary Hypertriglyceridemic Rats. Current Issues in Molecular Biology 44:5, pages 1889-1900.
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Aliaa Abdelmoniem Bedeir Eita. (2022) Milk thistle (Silybum marianum (L.)Gaertn.): An overview about its pharmacology and medicinal uses with an emphasis on oral diseases. Journal of Oral Biosciences 64:1, pages 71-76.
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Martina Hüttl, Irena Markova, Denisa Miklankova, Iveta Zapletalova, Martin Poruba, Zuzana Racova, Rostislav Vecera & Hana Malinska. (2021) The Beneficial Additive Effect of Silymarin in Metformin Therapy of Liver Steatosis in a Pre-Diabetic Model. Pharmaceutics 14:1, pages 45.
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Josif Vidimce, Evan Noel Pennell, Maxmilian Foo, Ryan Graeme Shiels, Sapha Shibeeb, Michael Watson & Andrew Cameron Bulmer. (2021) Effect of Silymarin Treatment on Circulating Bilirubin and Cardiovascular Disease Risk Factors in Healthy Men: A Single‐Blind, Randomized Crossover Trial. Clinical Pharmacology in Drug Development 10:10, pages 1156-1165.
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Karla MacDonald-Ramos, Layla Michán, Alejandra Martínez-Ibarra & Marco Cerbón. (2021) Silymarin is an ally against insulin resistance: A review. Annals of Hepatology 23, pages 100255.
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I MARKOVÁ, H MALÍNSKÁ, M HÜTTL, D MIKLÁNKOVÁ, O OLIYARNYK, M PORUBA, Z RÁCOVÁ, L KAZDOVÁ & R VEČEŘA. (2021) The Combination of Atorvastatin With Silymarin Enhances Hypolipidemic, Antioxidant and Anti-Inflammatory Effects in a Rat Model of Metabolic Syndrome. Physiological Research, pages 33-43.
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Marina Reguero, Marta Gómez de Cedrón, Sonia Wagner, Guillermo Reglero, José Carlos Quintela & Ana Ramírez de Molina. (2021) Precision Nutrition to Activate Thermogenesis as a Complementary Approach to Target Obesity and Associated-Metabolic-Disorders. Cancers 13:4, pages 866.
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Fernanda Caetano Camini & Daniela Caldeira Costa. (2020) Silymarin: not just another antioxidant. Journal of Basic and Clinical Physiology and Pharmacology 31:4.
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Michelle L. Montonye, Dan-Dan Tian, Tarana Arman, Katherine D. Lynch, Bruno Hagenbuch, Mary F. Paine & John D. Clarke. (2019) A Pharmacokinetic Natural Product-Disease-Drug Interaction: A Double Hit of Silymarin and Nonalcoholic Steatohepatitis on Hepatic Transporters in a Rat Model. Journal of Pharmacology and Experimental Therapeutics 371:2, pages 385-393.
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M. PORUBA, P. ANZENBACHER, Z. RACOVA, O. OLIYARNYK, M. HÜTTL, H. MALINSKA, I. MARKOVA, S. GURSKA, L. KAZDOVA & R. VECERA. (2019) The Effect of Combined Diet Containing n-3 Polyunsaturated Fatty Acids and Silymarin on Metabolic Syndrome in Rats. Physiological Research, pages S39-S50.
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Ying Li, Yin Wu, Ya-Jing Li, Lu Meng, Cong-Yang Ding & Zhan-Jun Dong. (2019) Effects of Silymarin on the In Vivo Pharmacokinetics of Simvastatin and Its Active Metabolite in Rats. Molecules 24:9, pages 1666.
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Hani M. Abdelsalam, Mai A. Samak & Amira E. Alsemeh. (2019) Synergistic therapeutic effects of Vitis vinifera extract and Silymarin on experimentally induced cardiorenal injury: The pertinent role of Nrf2. Biomedicine & Pharmacotherapy 110, pages 37-46.
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Atefeh Tajmohammadi, Bibi Marjan Razavi & Hossein Hosseinzadeh. (2018) Silybum marianum (milk thistle) and its main constituent, silymarin, as a potential therapeutic plant in metabolic syndrome: A review . Phytotherapy Research 32:10, pages 1933-1949.
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M. PORUBA, Z. MATUŠKOVÁ, L. KAZDOVÁ, O. OLIYARNYK, H. MALÍNSKÁ, I. TOZZI DI ANGELO & R. VEČEŘA. (2015) Positive Effects of Different Drug Forms of Silybin in the Treatment of Metabolic Syndrome. Physiological Research, pages S507-S512.
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