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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 9
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General Xenobiochemistry

Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans

Naoyuki NakadaAnalysis & Pharmacokinetics Research Laboratories, Astellas Pharma Inc., Kashima, Yodogawa-ku, Osaka, JapanCorrespondence[email protected]
&
Kazuo OdaAnalysis & Pharmacokinetics Research Laboratories, Astellas Pharma Inc., Kashima, Yodogawa-ku, Osaka, Japan
Pages 757-765 | Received 09 Jan 2015, Accepted 11 Feb 2015, Published online: 14 Apr 2015

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Shotaro Uehara, Yukako Yuki, Yasuhiro Uno, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki. (2018) Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines. Xenobiotica 48:4, pages 342-347.
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Hidetaka Kamimura & Satoshi Ito. (2016) Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound. Xenobiotica 46:6, pages 557-569.
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Articles from other publishers (8)

Robert S. Jones, Justin Q. Ly & Jae H. Chang. 2020. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters 555 594 .
Lars Ove Dragsted & Kajetan Trošt. 2019. The Human Gut-Liver-Axis in Health and Disease. The Human Gut-Liver-Axis in Health and Disease 147 164 .
Jakob Wallgren, Svante Vikingsson, Anna Åstrand, Martin Josefsson, Henrik Gréen, Johan Dahlén, Xiongyu Wu & Peter Konradsson. (2018) Synthesis and identifications of potential metabolites as biomarkers of the synthetic cannabinoid AKB-48. Tetrahedron 74:24, pages 2905-2913.
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Yoichi Naritomi, Seigo Sanoh & Shigeru Ohta. (2018) Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery. Drug Metabolism and Pharmacokinetics 33:1, pages 31-39.
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Seigo Sanoh & Shigeru Ohta. (2018) Contribution of chimeric mice with a humanized liver to the evaluation of pharmacology, toxicity, and pharmacokinetics in drug discovery and development創薬におけるヒト肝細胞キメラマウスを用いた薬効，毒性および薬物動態評価の有用性. Folia Pharmacologica Japonica 151:5, pages 213-220.
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Jakob Wallgren, Svante Vikingsson, Anders Johansson, Martin Josefsson, Henrik Green, Johan Dahlén, Xiongyu Wu & Peter Konradsson. (2017) Synthesis and identification of an important metabolite of AKB-48 with a secondary hydroxyl group on the adamantyl ring. Tetrahedron Letters 58:15, pages 1456-1458.
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Naoyuki Nakada. (2017) Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2. Pharmaceutical Research 34:4, pages 874-886.
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Naoyuki Nakada, Akio Kawamura, Hidetaka Kamimura, Koya Sato, Yasuhiro Kazuki, Masakazu Kakuni, Masato Ohbuchi, Kota Kato, Chise Tateno, Mitsuo Oshimura & Takashi Usui. (2016) Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans . Biopharmaceutics & Drug Disposition 37:1, pages 3-14.
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