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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 9
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General Xenobiochemistry

Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan

Shotaro UeharaLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan,
,
Yasuhiro UnoPharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Kainan, Wakayama, Japan,
,
Yuya HagihiraLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan,
,
Norie MurayamaLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan,
,
Makiko ShimizuLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan,
,
Takashi InoueDepartment of Applied Developmental Biology, Central Institute for Experimental Animals, Kawasaki, Japan, and
,
Erika SasakiDepartment of Applied Developmental Biology, Central Institute for Experimental Animals, Kawasaki, Japan, and ;Keio Advanced Research Center, Keio University, Minato-ku, Tokyo, Japan
&
Hiroshi YamazakiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan, Correspondence[email protected]
 show all
Pages 766-772 | Received 22 Jan 2015, Accepted 11 Feb 2015, Published online: 24 Mar 2015

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Morgan E. Chaney, Melia G. Romine, Helen Piontkivska & Anthony J. Tosi. (2020) Diversifying selection detected in only a minority of xenobiotic-metabolizing CYP1-3 genes among primate species. Xenobiotica 50:12, pages 1406-1412.
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Kazuyuki Nakanishi, Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki. (2018) Progesterone hydroxylation by cytochromes P450 2C and 3A enzymes in marmoset liver microsomes. Xenobiotica 48:8, pages 757-763.
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Shotaro Uehara, Yukako Yuki, Yasuhiro Uno, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki. (2018) Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines. Xenobiotica 48:4, pages 342-347.
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Shotaro Uehara, Yasuhiro Uno, Sakura Ishii, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki. (2017) Marmoset cytochrome P450 4A11, a novel arachidonic acid and lauric acid ω-hydroxylase expressed in liver and kidney tissues. Xenobiotica 47:7, pages 553-561.
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Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Eriko Okamoto, Erika Sasaki & Hiroshi Yamazaki. (2016) Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine. Xenobiotica 46:11, pages 977-985.
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Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Takako Suzuki, Masahiro Utoh, Erika Sasaki & Hiroshi Yamazaki. (2016) Caffeine 7-N-demethylation and C-8-oxidation mediated by liver microsomal cytochrome P450 enzymes in common marmosets. Xenobiotica 46:7, pages 573-578.
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Shotaro Uehara, Takashi Inoue, Masahiro Utoh, Akiko Toda, Makiko Shimizu, Yasuhiro Uno, Erika Sasaki & Hiroshi Yamazaki. (2016) Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol and midazolam, in common marmosets (Callithrix jacchus). Xenobiotica 46:2, pages 163-168.
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Articles from other publishers (16)

Yasuhiro Uno, Shotaro Uehara & Hiroshi Yamazaki. 2022. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary 329 364 .
S. R. Gretler, C. J. Finno, P. H. Kass & H. K. Knych. (2021) Functional phenotyping of the CYP2D6 probe drug codeine in the horse. BMC Veterinary Research 17:1.
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Zhe Feng, Siyi Bai, Ji Qi, Chaowei Sun, Yuhuang Zhang, Xiaoming Yu, Huwei Ni, Di Wu, Xiaoxiao Fan, Dingwei Xue, Shunjie Liu, Ming Chen, Junyi Gong, Peifa Wei, Mubin He, Jacky W. Y. Lam, Xinjian Li, Ben Zhong Tang, Lixia Gao & Jun Qian. (2021) Biologically Excretable Aggregation‐Induced Emission Dots for Visualizing Through the Marmosets Intravitally: Horizons in Future Clinical Nanomedicine. Advanced Materials 33:17, pages 2008123.
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Rajagopal N. Aravalli & Clifford J. Steer. (2020) Utility of Common Marmoset (Callithrix jacchus) Embryonic Stem Cells in Liver Disease Modeling, Tissue Engineering and Drug Metabolism. Genes 11:7, pages 729.
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Shotaro Uehara, Yasuhiro Uno & Hiroshi Yamazaki. (2020) The marmoset cytochrome P450 superfamily: Sequence/phylogenetic analyses, genomic structure, and catalytic function. Biochemical Pharmacology 171, pages 113721.
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Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki & Hiroshi Yamazaki. (2019) Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model. Current Drug Metabolism 20:2, pages 103-113.
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Morgan E. Chaney, Helen Piontkivska & Anthony J. Tosi. (2018) Retained duplications and deletions of CYP2C genes among primates. Molecular Phylogenetics and Evolution 125, pages 204-212.
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Kazuyuki Nakanishi, Shotaro Uehara, Takashi Kusama, Takashi Inoue, Kanami Shimura, Yusuke Kamiya, Norie Murayama, Makiko Shimizu, Yasuhiro Uno, Erika Sasaki & Hiroshi Yamazaki. (2018) In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants. Biochemical Pharmacology 152, pages 272-278.
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Shotaro Uehara, Yasuhiro Uno, Etsuko Tomioka, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki. (2017) Functional characterization and tissue expression of marmoset cytochrome P450 2E1. Biopharmaceutics & Drug Disposition 38:6, pages 394-397.
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Shotaro Uehara, Sakura Ishii, Yasuhiro Uno, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki. (2017) Regio- and Stereo-Selective Oxidation of a Cardiovascular Drug, Metoprolol, Mediated by Cytochrome P450 2D and 3A Enzymes in Marmoset Livers. Drug Metabolism and Disposition 45:8, pages 896-899.
Crossref
Shotaro Uehara, Yasuhiro Uno, Kazuyuki Nakanishi, Sakura Ishii, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki. (2017) Marmoset Cytochrome P450 3A4 Ortholog Expressed in Liver and Small-Intestine Tissues Efficiently Metabolizes Midazolam, Alprazolam, Nifedipine, and Testosterone. Drug Metabolism and Disposition 45:5, pages 457-467.
Crossref
Yasuhiro Uno, Shotaro Uehara & Hiroshi Yamazaki. (2016) Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes. Biochemical Pharmacology 121, pages 1-7.
Crossref
Fang Xie, Xinxin Ding & Qing-Yu Zhang. (2016) An update on the role of intestinal cytochrome P450 enzymes in drug disposition. Acta Pharmaceutica Sinica B 6:5, pages 374-383.
Crossref
S. Uehara, Y. Uno, Y. Yuki, T. Inoue, E. Sasaki & H. Yamazaki. (2016) A New Marmoset P450 4F12 Enzyme Expressed in Small Intestines and Livers Efficiently Metabolizes Antihistaminic Drug Ebastine. Drug Metabolism and Disposition 44:6, pages 833-841.
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Yoshinori Shimamoto, Kimie Niimi, Hiroshi Kitamura, Sae Tsubakishita & Eiki Takahashi. (2016) <i>In situ</i> hybridization study of <i>CYP2D</i> mRNA in the common marmoset brain. Experimental Animals 65:4, pages 465-471.
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Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Mirai Kawano, Makiko Shimizu, Akiko Toda, Masahiro Utoh, Erika Sasaki & Hiroshi Yamazaki. (2015) Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S -Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole . Drug Metabolism and Disposition 43:10, pages 1408-1416.
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