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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 9
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General Xenobiochemistry

Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines

Cong XuLaboratory of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P.R. China and ;Center of Safety Evaluation, Zhejiang Academy of Medical Sciences, Hangzhou, P.R. China
,
Mengyue LuoLaboratory of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P.R. China and
,
Huidi JiangLaboratory of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P.R. China and
,
Lushan YuLaboratory of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P.R. China and
&
Su ZengLaboratory of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P.R. China and Correspondence[email protected]
Pages 773-781 | Received 24 Dec 2014, Accepted 13 Feb 2015, Published online: 14 Apr 2015

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David E. Amacher. (2016) The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors. Expert Opinion on Drug Metabolism & Toxicology 12:12, pages 1463-1477.
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Xiaoqi Pan, Jie Zhou, Yan Chen, Xiaofang Xie, Chaolong Rao, Jie Liang, Ying Zhang & Cheng Peng. (2020) Classification, hepatotoxic mechanisms, and targets of the risk ingredients in traditional Chinese medicine-induced liver injury. Toxicology Letters 323, pages 48-56.
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Artitaya Thiengsusuk, Kanyarat Boonprasert & Kesara Na-Bangchang. (2019) A Systematic Review of Drug Metabolism Studies of Plants With Anticancer Properties: Approaches Applied and Limitations. European Journal of Drug Metabolism and Pharmacokinetics 45:2, pages 173-225.
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Hyesoo Jeong, Soolin Kim, Mi-yeon Kim, Jimin Lee, Byoung An, Hee-Doo Kim, Hyunyoung Jeong, Yun Song & Minsun Chang. (2018) Inhibitory and Inductive Effects of Opuntia ficus indica Extract and Its Flavonoid Constituents on Cytochrome P450s and UDP-Glucuronosyltransferases. International Journal of Molecular Sciences 19:11, pages 3400.
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Julia Yue Cui & Curtis D. Klaassen. (2016) RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:9, pages 1198-1217.
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Chenshu Xu, Min Huang & Huichang Bi. (2016) PXR- and CAR-mediated herbal effect on human diseases. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:9, pages 1121-1129.
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