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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 11
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General Xenobiochemistry

Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human

Jing NingDalian Medical University, Dalian, China, ;Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China,
,
Jie HouDepartment of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, China,
,
Ping WangLaboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China,
,
Jing-Jing WuLaboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China,
,
Zi-Ru DaiLaboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China,
,
Li-Wei ZouLaboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China,
,
Wei LiCollege of Medicine, Yangzhou University, Yangzhou, China, and
,
Guang-Bo GeLaboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China, Correspondence[email protected]
,
Xiao-Chi MaResearch Institute of Integrated Traditional and Western Medicine, Dalian Medical University, Dalian, ChinaCorrespondence[email protected]
&
Ling YangLaboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China,
show all
Pages 954-960 | Received 07 Feb 2015, Accepted 25 Mar 2015, Published online: 08 Jun 2015

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Ying-Yuan Lu, Hai-Xu Cheng, Xin Wang, Xiao-Wei Wang, Jun-Yi Liu, Pu Li, Ya-Qing Lou, Jun Li, Chuang Lu & Guo-Liang Zhang. (2017) Identification of cytochrome P450s involved in the metabolism of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1) using human recombinant enzymes and rat liver microsomes in vitro. Xenobiotica 47:8, pages 667-672.
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Articles from other publishers (10)

Yoshiaki Tanaka, Hitomi Okuyama, Miyu Nishikawa, Shin‐ichi Ikushiro, Mayumi Ikeda, Yu Ishima, Yuichi Ukawa, Kenichi Oe, Junji Terao & Rie Mukai. (2022) 8‐Prenylnaringenin tissue distribution and pharmacokinetics in mice and its binding to human serum albumin and cellular uptake in human embryonic kidney cells. Food Science & Nutrition 10:4, pages 1070-1080.
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Dongzhu Tu, Jing Ning, Liwei Zou, Ping Wang, Yani Zhang, Xiangge Tian, Feng Zhang, Jiang Zheng & Guangbo Ge. (2022) Unique Oxidative Metabolism of Bufalin Generates Two Reactive Metabolites That Strongly Inactivate Human Cytochrome P450 3A. Journal of Medicinal Chemistry 65:5, pages 4018-4029.
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Martin Krøyer Rasmussen. (2020) Porcine cytochrome P450 3A: current status on expression and regulation. Archives of Toxicology 94:6, pages 1899-1914.
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Ya-Qiao Wang, Xiao-Feng Shang, Lu Wang, Ping Zhang, Li-Wei Zou, Yun-Qing Song, Da-Cheng Hao, Sheng-Quan Fang, Guang-Bo Ge & Hui Tang. (2020) Interspecies variation of clopidogrel hydrolysis in liver microsomes from various mammals. Chemico-Biological Interactions 315, pages 108871.
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Wen-Long Wei, Jin-Jun Hou, Xia Wang, Yang Yu, Hao-Jv Li, Zhen-Wei Li, Zi-Jin Feng, Hua Qu, Wan-Ying Wu & De-An Guo. (2019) Venenum bufonis: An overview of its traditional use, natural product chemistry, pharmacology, pharmacokinetics and toxicology. Journal of Ethnopharmacology 237, pages 215-235.
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Wenlong Wei, Yang Yu, Xia Wang, Linhui Yang, Hang Zhang, Hongjian Ji, Zhenwei Li, Jinjun Hou, Wanying Wu & Dean Guo. (2019) Simultaneous Determination of Bufalin and Its Nine Metabolites in Rat Plasma for Characterization of Metabolic Profiles and Pharmacokinetic Study by LC–MS/MS. Molecules 24:9, pages 1662.
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Zi-Ru Dai, Jing Ning, Gui-Bo Sun, Ping Wang, Feng Zhang, Hong-Ying Ma, Li-Wei Zou, Jie Hou, Jing-Jing Wu, Guang-Bo Ge, Xiao-Bo Sun & Ling Yang. (2019) Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu. Frontiers in Pharmacology 10.
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Xiangge Tian, Chao Wang, Peipei Dong, Yue An, Xinyu Zhao, Weiru Jiang, Gang Wang, Jie Hou, Lei Feng, Yan Wang, Guangbo Ge, Xiaokui Huo, Jing Ning & Xiaochi Ma. (2018) Arenobufagin is a novel isoform-specific probe for sensing human sulfotransferase 2A1. Acta Pharmaceutica Sinica B 8:5, pages 784-794.
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Yangliu Xia, Huilin Pang, Tongyi Dou, Ping Wang & Guangbo Ge. (2018) Interspecies comparison in the COMT-mediated methylation of 3-BTD. RSC Advances 8:29, pages 16278-16284.
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Hong-Ying Ma, Jia-Da Yang, Jie Hou, Li-Wei Zou, Qiang Jin, Da-Cheng Hao, Jing Ning, Guang-Bo Ge & Ling Yang. (2017) Comparative metabolism of DDAO benzoate in liver microsomes from various species. Toxicology in Vitro 44, pages 280-286.
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