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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 11
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General Xenobiochemistry

Mechanism-based inhibition of CYPs and RMs-induced hepatoxicity by rutaecarpine

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Pages 978-989 | Received 08 Feb 2015, Accepted 04 Apr 2015, Published online: 08 Jun 2015

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Read on this site (6)

Caiqin Yan, Ting Peng, Tingting Zhang, Yuan Wang, Na Li, Kai Wang & Xijuan Jiang. (2023) Molecular mechanisms of hepatotoxicity induced by compounds occurring in Evodiae Fructus. Drug Metabolism Reviews 55:1-2, pages 75-93.
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Kai Wang, Qing Gao, Tingting Zhang, Jinqiu Rao, Liqin Ding & Feng Qiu. (2020) Inhibition of CYP2C9 by natural products: insight into the potential risk of herb-drug interactions. Drug Metabolism Reviews 52:2, pages 235-257.
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Lu Liu, Xiangang Cao, Tingxin Li & Xiaohua Li. (2019) Effects of catalpol on the activity of human liver cytochrome P450 enzymes. Xenobiotica 49:11, pages 1289-1295.
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Ai-Hong Yang, Lei Zhang, De-Xian Zhi, Wen-Li Liu, Xue Gao & Xin He. (2018) Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole. Xenobiotica 48:11, pages 1164-1172.
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Jixiao Lang, Wei Li, Jingming Zhao, Kaiyou Wang & Dexi Chen. (2017) Inhibitory effects of curculigoside on human liver cytochrome P450 enzymes. Xenobiotica 47:10, pages 849-855.
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Dongwu Wang, Xin Wang, Xiaoting Gu, Yu Zhang, Yanhui Jiang, Youping Liu & Xin Di. (2023) Systematic screening of hepatoprotective components from traditional Chinese medicine: Zuojin Pill as an example. Journal of Ethnopharmacology, pages 117556.
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Si-Jia Xiao, Xi-Ke Xu, Wei Chen, Jia-Yun Xin, Wen-Lin Yuan, Xian-Peng Zu & Yun-Heng Shen. (2023) Traditional Chinese medicine Euodiae Fructus: botany, traditional use, phytochemistry, pharmacology, toxicity and quality control. Natural Products and Bioprospecting 13:1.
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Dan Zhang, Jintao Lü, Zhixin Ren, Xiaomeng Zhang, Huanzhang Wu, Rina Sa, Xiaofang Wang, Yu Wang, Zhijian Lin & Bing Zhang. (2022) Potential cardiotoxicity induced by Euodiae Fructus: In vivo and in vitro experiments and untargeted metabolomics research. Frontiers in Pharmacology 13.
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Jie-Jie Xu, Hai-Di Li, Ming-Fei Wu, Lin Zhu, Xiao-Sa Du, Juan-Juan Li, Zeng Li, Xiao-Ming Meng, Cheng Huang & Jun Li. (2021) 3-B-RUT, a derivative of RUT, protected against alcohol-induced liver injury by attenuating inflammation and oxidative stress. International Immunopharmacology 95, pages 107471.
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Yutao Liu, Chang Liu, Yamei Liu, Quanli Ge & Chen Sun. (2020) Cytochrome P450 Mediated Bioactivation of Rutaevin, a Bioactive and Potentially Hepatotoxic Component of Evodia Rutaecarpa . Chemical Research in Toxicology 33:12, pages 3054-3064.
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Manlin Li & Changhong Wang. (2020) Traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the fruit of Tetradium ruticarpum: A review. Journal of Ethnopharmacology 263, pages 113231.
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Laishram Surbala, Chingakham Brajakishor Singh, Rajkumari Vidyabati Devi & Oinam Joychandra Singh. (2020) Rutaecarpine exhibits anti-diabetic potential in high fat diet–multiple low dose streptozotocin induced type 2 diabetic mice and in vitro by modulating hepatic glucose homeostasis. Journal of Pharmacological Sciences 143:4, pages 307-314.
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Xiaoqi Pan, Jie Zhou, Yan Chen, Xiaofang Xie, Chaolong Rao, Jie Liang, Ying Zhang & Cheng Peng. (2020) Classification, hepatotoxic mechanisms, and targets of the risk ingredients in traditional Chinese medicine-induced liver injury. Toxicology Letters 323, pages 48-56.
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Xiaojiaoyang Li, Junde Ge, Qi Zheng, Jiaxiang Zhang, Rong Sun & Runping Liu. (2020) Evodiamine and rutaecarpine from Tetradium ruticarpum in the treatment of liver diseases. Phytomedicine 68, pages 153180.
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Xin He, Zi-jun Wu, Li-li Wang, Xue Gao, Yue Hai, Wen-li Liu, Le-mei Du, Lei Zhang, Ai-hong Yang & Nan-nan Huang. (2019) An important mechanism of herb-induced hepatotoxicity: To produce RMs based on active functional groups-containing ingredients from phytomedicine by binding CYP450s. Chinese Herbal Medicines 11:3, pages 239-257.
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Zhi Liu, Xin He, Lili Wang, Yunhua Zhang, Yue Hai & Rui Gao. (2019) Chinese Herbal Medicine Hepatotoxicity: The Evaluation and Recognization Based on Large-scale Evidence Database. Current Drug Metabolism 20:2, pages 138-146.
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Zefeng Zhao, Xirui He, Wei Han, Xufei Chen, Peiliang Liu, Xue Zhao, Xing Wang, Lixin Zhang, Shaoping Wu & Xiaohui Zheng. (2019) Genus Tetradium L.: A comprehensive review on traditional uses, phytochemistry, and pharmacological activities. Journal of Ethnopharmacology 231, pages 337-354.
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Xiao-Fei Shang, Susan L. Morris-Natschke, Guan-Zhou Yang, Ying-Qian Liu, Xiao Guo, Xiao-Shan Xu, Masuo Goto, Jun-Cai Li, Ji-Yu Zhang & Kuo-Hsiung Lee. (2018) Biologically active quinoline and quinazoline alkaloids part II. Medicinal Research Reviews 38:5, pages 1614-1660.
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Barbara M. Zietek, Marija Mladic, Ben Bruyneel, Wilfried M.A. Niessen, Maarten Honing, Govert W. Somsen & Jeroen Kool. (2018) Nanofractionation Platform with Parallel Mass Spectrometry for Identification of CYP1A2 Inhibitors in Metabolic Mixtures. SLAS Discovery 23:3, pages 283-293.
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Takamitsu Sasaki, Yu Sato, Takeshi Kumagai, Kouichi Yoshinari & Kiyoshi Nagata. (2017) Effect of health foods on cytochrome P450-mediated drug metabolism. Journal of Pharmaceutical Health Care and Sciences 3:1.
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Amrinder Singh & Kaicun Zhao. 2017. Neurobiology of Chinese Herb Medicine. Neurobiology of Chinese Herb Medicine 197 232 .
Huarong Xu, Yajing Geng, Ran Liu, Ziyue Yuan, Xujia Liu, Qing Li & Kaishun Bi. (2016) Qualitative screening of absorbed indoloquinazoline alkaloids and their metabolites in rat plasma after the oral administration of Wu-Zhu-Yu decoction by high-resolution mass spectrometry with multiple data mining algorithms. Journal of Separation Science 39:16, pages 3260-3266.
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