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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 12
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Animal Pharmacokinetics and Metabolism

Utilizing 19F NMR to investigate drug disposition early in drug discovery

Haitao HuDepartment of Discovery Chemistry and
,
Naijia HuangDepartment of Drug Disposition, Lilly Research Laboratories, Indianapolis, IN, USA
,
Ping YiDepartment of Drug Disposition, Lilly Research Laboratories, Indianapolis, IN, USA
,
Yu-Hua HuiDepartment of Drug Disposition, Lilly Research Laboratories, Indianapolis, IN, USA
,
Robert D. DallyDepartment of Discovery Chemistry and
,
William J. EhlhardtDepartment of Drug Disposition, Lilly Research Laboratories, Indianapolis, IN, USA
&
Palaniappan KulanthaivelDepartment of Drug Disposition, Lilly Research Laboratories, Indianapolis, IN, USACorrespondence[email protected]
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Pages 1081-1091 | Received 20 Feb 2015, Accepted 10 Apr 2015, Published online: 06 May 2015

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David Pearson, Maxime Garnier, Alexandre Luneau, Alexander David James & Markus Walles. (2019) 19F-NMR-based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers. Xenobiotica 49:8, pages 953-960.
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Articles from other publishers (4)

Gilad Nahari, Roy E. Hoffman & Edit Y. Tshuva. (2021) From medium to endoplasmic reticulum: Tracing anticancer phenolato titanium(IV) complex by 19F NMR detection. Journal of Inorganic Biochemistry 221, pages 111492.
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Rahul Sakla & D. Amilan Jose. (2021) New fluorinated manganese carbonyl complexes for light controlled carbon monoxide (CO) release and the use of benchtop 19F-NMR spectroscopy. Inorganica Chimica Acta 516, pages 120134.
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Haitao Hu, Kishore Kumar Katyayan, Boris A. Czeskis, Everett J. Perkins & Palaniappan Kulanthaivel. (2017) Comparison between Radioanalysis and 19 F Nuclear Magnetic Resonance Spectroscopy in the Determination of Mass Balance, Metabolism, and Distribution of Pefloxacin . Drug Metabolism and Disposition 45:4, pages 399-408.
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X. Li & K. Hu. 2017. 85 143 .

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