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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 12
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General Xenobiochemistry

Mechanism-based inactivation of CYP2C9 by linderane

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Pages 1037-1046 | Received 18 Mar 2015, Accepted 11 Apr 2015, Published online: 11 Jun 2015

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Read on this site (4)

Tingting Zhang, Jinqiu Rao, Wei Li, Kai Wang & Feng Qiu. (2020) Mechanism-based inactivation of cytochrome P450 enzymes by natural products based on metabolic activation. Drug Metabolism Reviews 52:4, pages 501-530.
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Kai Wang, Qing Gao, Tingting Zhang, Jinqiu Rao, Liqin Ding & Feng Qiu. (2020) Inhibition of CYP2C9 by natural products: insight into the potential risk of herb-drug interactions. Drug Metabolism Reviews 52:2, pages 235-257.
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Bo Wen & Peter Gorycki. (2019) Bioactivation of herbal constituents: mechanisms and toxicological relevance. Drug Metabolism Reviews 51:4, pages 453-497.
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Yifeng Zhou, Liling Wang, Yuchuan Qin, Lichun Chen, Qing Ge & Jianwei Mao. (2018) A sequential separation of linderane and norisoboldine using supercritical fluid and ionic liquid-based ultrasonic-assisted extraction from Lindera aggregate. Separation Science and Technology 53:18, pages 2916-2925.
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Articles from other publishers (15)

Yi Tao, Yuling Deng & Ping Wang. (2024) Traditional uses, phytochemistry, pharmacology, processing methods and quality control of Lindera aggregata (Sims) Kosterm: A critical review. Journal of Ethnopharmacology 318, pages 116954.
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Ting Peng, Jinqiu Rao, Tingting Zhang, Yuan Wang, Na Li, Qing Gao, Xinchi Feng, Zhaohui Song, Kai Wang & Feng Qiu. (2023) Elucidation of the relationship between evodiamine-induced liver injury and CYP3A4-mediated metabolic activation by UPLC-MS/MS analysis. Analytical and Bioanalytical Chemistry.
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Xiang Chen, Luyao Han, Yulin Zhao, Haoyan Huang, He Pan, Chenmeng Zhang, Huili Chen, Shanliang Sun, Sihui Yao, Xijing Chen & Yongjie Zhang. (2023) Mechanistic Study of Icaritin-Induced Inactivation of Cytochrome P450 2C9. Drug Metabolism and Disposition 51:6, pages 771-781.
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Yi Zhang, Binhao Cai, Yingying Li, Ying Xu, Yuhan Wang, Lulu Zheng, Xiaochun Zheng, Lina Yin, Gaozhi Chen, Yunxiang Wang, Guang Liang & Lingfeng Chen. (2023) Identification of linderalactone as a natural inhibitor of SHP2 to ameliorate CCl4-induced liver fibrosis. Frontiers in Pharmacology 14.
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Guode Zhao, Yufei Ma, Xu Wang, Wei Li, Yuqin Chen, Weiwei Li, Ying Peng & Jiang Zheng. (2022) Configurational Alteration Results in Change in Hepatotoxicity of Asarone. Journal of Agricultural and Food Chemistry 71:1, pages 884-894.
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Qinger Huang, Xiaojie Yan, Rongjun Liao, Kaohua Liu, Luping Qin & Bo Zhu. (2023) <i>Lindera aggregata</i> (Sims) Kosterm: A Systematic Review of its Traditional Applications, Phytochemical and Pharmacological Properties, and Quality Control. Medicinal Plant Biology 0:0, pages 0-0.
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Hong Pan, Lin Chen, Guohong Zhai, Qi Luo, Chao Fang & Fuguo Shi. (2022) Feature MS fragments-based method for identification of toxic furanoids in biological samples. Journal of Pharmaceutical and Biomedical Analysis 221, pages 115035.
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Tingting Zhang, Ting Peng, Jinqiu Rao, Kai Wang & Feng Qiu. (2022) Quantitation of Diclofenac, Tolbutamide, and Warfarin as Typical CYP2C9 Substrates in Rat Plasma by UPLC-MS/MS and Its Application to Evaluate Linderane-Mediated Herb-Drug Interactions. Journal of Analytical Methods in Chemistry 2022, pages 1-11.
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Kai Wang, Tingting Zhang, Jinqiu Rao, Ting Peng, Qing Gao, Xinchi Feng & Feng Qiu. (2022) Drug-drug interactions induced by Linderane based on mechanism-based inactivation of CYP2C9 and the molecular mechanisms. Bioorganic Chemistry 118, pages 105478.
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Zhihai Ke & Ying-Yeung Yeung. 2022. Comprehensive Heterocyclic Chemistry IV. Comprehensive Heterocyclic Chemistry IV 412 449 .
Ying Liu, Shiyu Zhang, Tingting Jiang, Rong Tan, Yao Fu, Xiaojing Yang, Bowen Gong, Ying Zou, Weiwei Li & Jiang Zheng. (2021) Mechanistic study of bergamottin-induced inactivation of CYP2C9. Food and Chemical Toxicology 153, pages 112278.
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Tingting Jiang, Ting Cheng, Jing Li, Mengyue Zhou, Rong Tan, Xiaojing Yang, Yang Wang, Weiwei Li & Jiang Zheng. (2020) Bergaptol, a mechanism-based inactivator of CYP2C9. Medicinal Chemistry Research 29:7, pages 1230-1237.
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Haijun Zhang, Chunping Zhu, Zhe Sun, Xiaoguang Yan, Huihui Wang, Haibo Xu, Jiani Ma & Yanrong Zhang. (2019) Linderane protects pancreatic β cells from streptozotocin (STZ)-induced oxidative damage. Life Sciences 233, pages 116732.
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Wei Xie, Yangliang Ye, Ying Feng, Tifei Xu, Suling Huang, Jianhua Shen & Ying Leng. (2018) Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3. Frontiers in Pharmacology 9.
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Ole Kristian Forstrønen Thu, Olav Spigset & Bent Hellum. (2017) Noncompetitive inhibition of human CYP2C9 in vitro by a commercial Rhodiola rosea product . Pharmacology Research & Perspectives 5:4, pages e00324.
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