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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 1
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General Xenobiochemistry

Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes

Risto O. JuvonenFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland and Correspondence[email protected]
,
Mira KuusistoFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland and ;Department of Biological and Environmental Science & Nanoscience Center, University of Jyvaskyla, Jyvaskyla, Finland
,
Carolin FohrgrupFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland and
,
Mari H. PitkänenFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland and
,
Tapio J. NevalainenFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland and
,
Seppo AuriolaFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland and
,
Hannu RaunioFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland and
,
Markku PasanenFaculty of Health Sciences, School of Pharmacy, University of Eastern Finland, Kuopio, Finland and
&
Olli T. PentikäinenDepartment of Biological and Environmental Science & Nanoscience Center, University of Jyvaskyla, Jyvaskyla, Finland
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Pages 14-24 | Received 16 Mar 2015, Accepted 01 May 2015, Published online: 11 Jun 2015

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Risto O. Juvonen, Elmeri M. Jokinen, Juhani Huuskonen, Olli Kärkkäinen, Hannu Raunio & Olli T. Pentikäinen. (2021) Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13. Xenobiotica 51:11, pages 1207-1216.
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Risto O. Juvonen, Mira Ahinko, Juhani Huuskonen, Hannu Raunio & Olli T. Pentikäinen. (2019) Development of new Coumarin-based profluorescent substrates for human cytochrome P450 enzymes. Xenobiotica 49:9, pages 1015-1024.
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Articles from other publishers (10)

永敏 刘. (2023) Research Progress of CYP450 Substrates, Inhibitors, Inducers and Species Specificity. Pharmacy Information 12:02, pages 70-80.
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Michaela Šadibolová, Risto O. Juvonen, Seppo Auriola & Iva Boušová. (2022) In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity. Archives of Toxicology 96:3, pages 793-808.
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Risto O. Juvonen, Mira Ahinko, Elmeri M. Jokinen, Juhani Huuskonen, Hannu Raunio & Olli T. Pentikäinen. (2021) Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling. ACS Omega 6:17, pages 11286-11296.
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R. Kanimozhi & V. Arjunan. (2021) FT-IR, FT-Raman, NMR Spectroscopic and DFT Quantum Chemical Investigations of 6-Methylcoumarin. Asian Journal of Chemistry 33:11, pages 2715-2722.
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Hannu Raunio, Olli Pentikäinen & Risto O. Juvonen. (2020) Coumarin-Based Profluorescent and Fluorescent Substrates for Determining Xenobiotic-Metabolizing Enzyme Activities In Vitro. International Journal of Molecular Sciences 21:13, pages 4708.
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Joan Eilstein, Sébastien Grégoire, Aurélie Fabre, Eric Arbey, Camille Géniès, Hélène Duplan, Helga Rothe, Corie Ellison, Richard Cubberley, Andreas Schepky, Daniela Lange, Martina Klaric, Nicola J. Hewitt & Carine Jacques‐Jamin. (2020) Use of human liver and EpiSkin™ S9 subcellular fractions as a screening assays to compare the in vitro hepatic and dermal metabolism of 47 cosmetics‐relevant chemicals. Journal of Applied Toxicology 40:3, pages 416-433.
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Xiaoyi Qi, Tongyi Dou, Zhongqiong Wang, Jianming Wu, Ling Yang, Su Zeng, Mingming Deng, Muhan Lü & Sicheng Liang. (2019) Inhibition of human cytochrome P450 2A6 by 7-hydroxycoumarin analogues: Analysis of the structure-activity relationship and isoform selectivity. European Journal of Pharmaceutical Sciences 136, pages 104944.
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Mira Ahinko, Sanna Niinivehmas, Elmeri Jokinen & Olli T. Pentikäinen. (2018) Suitability of MMGBSA for the selection of correct ligand binding modes from docking results . Chemical Biology & Drug Design 93:4, pages 522-538.
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Sami T. Kurkinen, Sanna Niinivehmas, Mira Ahinko, Sakari Lätti, Olli T. Pentikäinen & Pekka A. Postila. (2018) Improving Docking Performance Using Negative Image-Based Rescoring. Frontiers in Pharmacology 9.
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Salla I. Virtanen, Sanna P. Niinivehmas & Olli T. Pentikäinen. (2015) Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening. Journal of Molecular Graphics and Modelling 62, pages 303-318.
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