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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 4
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General Xenobiochemistry

Mechanism-based inactivation of cytochrome P450 2B6 by isopsoralen

Dan LuSchool of Pharmacy and
,
Lin JiSchool of Pharmacy and
,
Liwei ZhengSchool of Pharmacy and
,
Jiaojiao CaoSchool of Pharmacy and
,
Ying PengSchool of Pharmacy and Correspondence[email protected]
&
Jiang ZhengKey Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang, Liaoning, P. R. China and ;Division of Gastroenterology and Hepatology, Department of Pediatrics, Center for Developmental Therapeutics, Seattle Children’s Research Institute, University of Washington School of Medicine, Seattle, WA, USACorrespondence[email protected]
Pages 335-341 | Received 02 Jun 2015, Accepted 25 Jul 2015, Published online: 17 Aug 2015

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Tingting Zhang, Jinqiu Rao, Wei Li, Kai Wang & Feng Qiu. (2020) Mechanism-based inactivation of cytochrome P450 enzymes by natural products based on metabolic activation. Drug Metabolism Reviews 52:4, pages 501-530.
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Bo Wen & Peter Gorycki. (2019) Bioactivation of herbal constituents: mechanisms and toxicological relevance. Drug Metabolism Reviews 51:4, pages 453-497.
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Articles from other publishers (6)

Dongzhu Tu, Jing Ning, Liwei Zou, Ping Wang, Yani Zhang, Xiangge Tian, Feng Zhang, Jiang Zheng & Guangbo Ge. (2022) Unique Oxidative Metabolism of Bufalin Generates Two Reactive Metabolites That Strongly Inactivate Human Cytochrome P450 3A. Journal of Medicinal Chemistry 65:5, pages 4018-4029.
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Ying Liu, Shiyu Zhang, Tingting Jiang, Rong Tan, Yao Fu, Xiaojing Yang, Bowen Gong, Ying Zou, Weiwei Li & Jiang Zheng. (2021) Mechanistic study of bergamottin-induced inactivation of CYP2C9. Food and Chemical Toxicology 153, pages 112278.
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Yali Ren, Xiaominting Song, Lu Tan, Chuanjie Guo, Miao Wang, Hui Liu, Zhixing Cao, Yuzhi Li & Cheng Peng. (2020) A Review of the Pharmacological Properties of Psoralen. Frontiers in Pharmacology 11.
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Mika Kosaka, Donglu Zhang, Simon Wong & Zhengyin Yan. (2020) NADPH-Independent Inactivation of CYP2B6 and NADPH-Dependent Inactivation of CYP3A4/5 by PBD: Potential Implication for Assessing Covalent Modulators for Time-Dependent Inhibition. Drug Metabolism and Disposition 48:8, pages 655-661.
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Tingting Jiang, Ting Cheng, Jing Li, Mengyue Zhou, Rong Tan, Xiaojing Yang, Yang Wang, Weiwei Li & Jiang Zheng. (2020) Bergaptol, a mechanism-based inactivator of CYP2C9. Medicinal Chemistry Research 29:7, pages 1230-1237.
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Jian Wang, Gang Wang, Li Gong, Guanwen Sun, Bin Shi, Huhe Bao & Yan Duan. (2017) Isopsoralen regulates PPAR‑γ/WNT to inhibit oxidative stress in osteoporosis. Molecular Medicine Reports.
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