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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 6
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Clinical Pharmacokinetics and Metabolism

Effect of grapefruit juice and food on the pharmacokinetics of pirfenidone in healthy Chinese volunteers: a diet–drug interaction study

Jinqing HuInstitution of National Drug Clinical Trials, Guangzhou Brain Hospital (Guangzhou Huiai Hospital, the Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, China,
,
Dewei ShangInstitution of National Drug Clinical Trials, Guangzhou Brain Hospital (Guangzhou Huiai Hospital, the Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, China,
,
Xinwen XuEbang Pharmaceutical Co. Ltd, Zhuhai, China, and
,
Xiuling HeInstitution of National Drug Clinical Trials, Guangzhou Brain Hospital (Guangzhou Huiai Hospital, the Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, China, ;Department of Pharmacy, Xinhui People’s Hospital of Jiangmen, Jiangmen, China
,
Xiaojia NiInstitution of National Drug Clinical Trials, Guangzhou Brain Hospital (Guangzhou Huiai Hospital, the Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, China,
,
Ming ZhangInstitution of National Drug Clinical Trials, Guangzhou Brain Hospital (Guangzhou Huiai Hospital, the Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, China,
,
Zhanzhang WangInstitution of National Drug Clinical Trials, Guangzhou Brain Hospital (Guangzhou Huiai Hospital, the Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, China,
,
Chang QiuInstitution of National Drug Clinical Trials, Guangzhou Brain Hospital (Guangzhou Huiai Hospital, the Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, China,
,
Shuhua DengInstitution of National Drug Clinical Trials, Guangzhou Brain Hospital (Guangzhou Huiai Hospital, the Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, China,
,
Haoyang LuInstitution of National Drug Clinical Trials, Guangzhou Brain Hospital (Guangzhou Huiai Hospital, the Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, China,
,
Xiuqing ZhuInstitution of National Drug Clinical Trials, Guangzhou Brain Hospital (Guangzhou Huiai Hospital, the Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, China,
,
Wencan HuangInstitution of National Drug Clinical Trials, Guangzhou Brain Hospital (Guangzhou Huiai Hospital, the Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, China,
&
Yuguan WenInstitution of National Drug Clinical Trials, Guangzhou Brain Hospital (Guangzhou Huiai Hospital, the Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, China, Correspondence[email protected]
 show all
Pages 516-521 | Received 16 Jul 2015, Accepted 28 Aug 2015, Published online: 25 Sep 2015

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Yongjie Zhang, Rei Sato, Tatsuki Fukami, Masataka Nakano & Miki Nakajima. (2021) Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver. Xenobiotica 51:12, pages 1352-1359.
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Yuzhen Jia, Jie Liu & Jisen Xu. (2018) Influence of grapefruit juice on pharmacokinetics of triptolide in rats grapefruit juice on the effects of triptolide. Xenobiotica 48:4, pages 407-411.
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Jorge L. Poo, Juan R. Aguilar, Raul Bernal-Reyes, Rosalba Alonso-Campero, Frida Gasca, Larissa Hernández, Everardo Pineyro-Garza, Magdalena Gomez-Silva, Maria Elena Gamino, Mario González-de la Parra, Pedro Peña, Nadiel Hernández, Graciela Tapia & Linda E. Muñoz-Espinosa. (2023) Prolonged release pirfenidone pharmacokinetics is modified in cirrhosis GENESIS study. Biomedicine & Pharmacotherapy 168, pages 115712.
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Peile Wang, Hui Li, Shanshan Chen, Han Xing, Jing Yang, Guojun Zhang & Xiaojian Zhang. (2023) Multicenter Population Pharmacokinetics and Exposure–Efficacy Analysis of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis. Clinical Pharmacokinetics 62:6, pages 921-930.
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Ladan Panahi, George Udeani, Andrew Scott Tenpas, Theresa Ofili, Elizabeth Marie Aguilar, Sarah Burchard, Alexandra Ruth Ritenour, April Jacob Chennat, Nehal Ahmed, Chairat Atphaisit, Crystal Chi, Jesus Cruz III, Monica D. Deleon, Samantha Lee, Zack Mayo, Mackenzie Mcbeth, Mariel Morales, Jennifer N. Nwosu, Kelly Palacios, Jaycob M. Pena & Nitza Vara. 2022. Idiopathic Pulmonary Fibrosis. Idiopathic Pulmonary Fibrosis.
Syed Faisal Zaidi, Rayan Mgarry, Abdullah Alsanea, Sakar Khalid Almutairi, Yaser Alsinnari, Saad Alsobaei & Kanwal Ahmed. (2021) A Questionnaire-Based Survey to Assess the Level of Knowledge and Awareness about Drug–Food Interactions among General Public in Western Saudi Arabia. Pharmacy 9:2, pages 76.
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Monica Butnariu & Marian Butu. 2021. Phytomedicine. Phytomedicine 343 376 .
Michael Grimm, Mirko Koziolek, Marwa Saleh, Felix Schneider, Grzegorz Garbacz, Jens-Peter Kühn & Werner Weitschies. (2018) Gastric Emptying and Small Bowel Water Content after Administration of Grapefruit Juice Compared to Water and Isocaloric Solutions of Glucose and Fructose: A Four-Way Crossover MRI Pilot Study in Healthy Subjects. Molecular Pharmaceutics 15:2, pages 548-559.
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Lin Pan, Paula Belloni, Han Ting Ding, Jianshuang Wang, Christopher M. Rubino & Wendy S. Putnam. (2017) A Pharmacokinetic Bioequivalence Study Comparing Pirfenidone Tablet and Capsule Dosage Forms in Healthy Adult Volunteers. Advances in Therapy 34:9, pages 2071-2082.
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J. Abraham Domínguez-Avila, Abraham Wall-Medrano, Gustavo R. Velderrain-Rodríguez, C.-Y. Oliver Chen, Norma Julieta Salazar-López, Maribel Robles-Sánchez & Gustavo A. González-Aguilar. (2017) Gastrointestinal interactions, absorption, splanchnic metabolism and pharmacokinetics of orally ingested phenolic compounds. Food & Function 8:1, pages 15-38.
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