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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 6
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Clinical Pharmacokinetics and Metabolism

Effect of grapefruit juice and food on the pharmacokinetics of pirfenidone in healthy Chinese volunteers: a diet–drug interaction study

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Pages 516-521 | Received 16 Jul 2015, Accepted 28 Aug 2015, Published online: 25 Sep 2015

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Yongjie Zhang, Rei Sato, Tatsuki Fukami, Masataka Nakano & Miki Nakajima. (2021) Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver. Xenobiotica 51:12, pages 1352-1359.
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Peile Wang, Hui Li, Shanshan Chen, Han Xing, Jing Yang, Guojun Zhang & Xiaojian Zhang. (2023) Multicenter Population Pharmacokinetics and Exposure–Efficacy Analysis of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis. Clinical Pharmacokinetics 62:6, pages 921-930.
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Michael Grimm, Mirko Koziolek, Marwa Saleh, Felix Schneider, Grzegorz Garbacz, Jens-Peter Kühn & Werner Weitschies. (2018) Gastric Emptying and Small Bowel Water Content after Administration of Grapefruit Juice Compared to Water and Isocaloric Solutions of Glucose and Fructose: A Four-Way Crossover MRI Pilot Study in Healthy Subjects. Molecular Pharmaceutics 15:2, pages 548-559.
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Lin Pan, Paula Belloni, Han Ting Ding, Jianshuang Wang, Christopher M. Rubino & Wendy S. Putnam. (2017) A Pharmacokinetic Bioequivalence Study Comparing Pirfenidone Tablet and Capsule Dosage Forms in Healthy Adult Volunteers. Advances in Therapy 34:9, pages 2071-2082.
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J. Abraham Domínguez-Avila, Abraham Wall-Medrano, Gustavo R. Velderrain-Rodríguez, C.-Y. Oliver Chen, Norma Julieta Salazar-López, Maribel Robles-Sánchez & Gustavo A. González-Aguilar. (2017) Gastrointestinal interactions, absorption, splanchnic metabolism and pharmacokinetics of orally ingested phenolic compounds. Food & Function 8:1, pages 15-38.
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