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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 8
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General Xenobiochemistry

Rhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A

Chung-Ping YuSchool of Chinese Medicine, China Medical University, Taichung, Taiwan, R.O.C.,
,
Hui-Ju LinSchool of Chinese Medicine, China Medical University, Taichung, Taiwan, R.O.C., ;Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan, R.O.C.,
,
Shiuan-Pey LinSchool of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C.,
,
Chi-Sheng ShiaSchool of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C.,
,
Pei-Hua ChangGraduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan, R.O.C., and
,
Yu-Chi HouSchool of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C., ;Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan, R.O.C.
&
Yo-Wen HsiehSchool of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C., ;Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan, R.O.C.Correspondence[email protected]
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Pages 677-682 | Received 09 Sep 2015, Accepted 03 Nov 2015, Published online: 04 Dec 2015

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Xixi Huang, Rui Zhang, Tingyu Yang, Ye Wei, Chunxiao Yang, Jiani Zhou, Yani Liu & Shaojun Shi. (2021) Inhibition effect of epigallocatechin-3-gallate on the pharmacokinetics of calcineurin inhibitors, tacrolimus, and cyclosporine A, in rats. Expert Opinion on Drug Metabolism & Toxicology 17:1, pages 121-134.
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Articles from other publishers (11)

Wenhao Cheng, Kexin Xia, Siyang Wu & Yingfei Li. (2023) Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update. Current Drug Metabolism 24:1, pages 28-69.
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Jinping Zhou, Rui Zhang, Pengpeng Guo, Peixia Li, Xixi Huang, Ye Wei, Chunxiao Yang, Jiali Zhou, Tingyu Yang, Yani Liu & Shaojun Shi. (2022) Effects of intestinal microbiota on pharmacokinetics of cyclosporine a in rats. Frontiers in Microbiology 13.
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Mohamad Hesam Shahrajabian, Qi Cheng & Wenli Sun. (2022) Wonderful Natural Drugs with Surprising Nutritional Values, Rheum Species, Gifts of the Nature. Letters in Organic Chemistry 19:10, pages 818-826.
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Jie Li, Shuting Wang, Fengjie Tian, Shuang-Qing Zhang & Hongtao Jin. (2022) Advances in Pharmacokinetic Mechanisms of Transporter-Mediated Herb-Drug Interactions. Pharmaceuticals 15:9, pages 1126.
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H. J. Weng & T. F. Tsai. (2021) ABCB1 in dermatology: roles in skin diseases and their treatment. Journal of Molecular Medicine 99:11, pages 1527-1538.
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Shuting Wang, Wanfang Li, Jianbo Yang, Zengyan Yang, Cuiping Yang & Hongtao Jin. (2020) Research Progress of Herbal Medicines on Drug Metabolizing Enzymes: Consideration Based on Toxicology. Current Drug Metabolism 21:12, pages 913-927.
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Shahid AkbarShahid Akbar. 2020. Handbook of 200 Medicinal Plants. Handbook of 200 Medicinal Plants 1527 1537 .
Xin Tian, Yuanyuan Chang, Jingyao Wei, Ruijuan Liu, Li Wang, Ji Zhang & Xiaojian Zhang. (2019) Baicalin reduces ciclosporin bioavailability by inducing intestinal p-glycoprotein in rats. Journal of Pharmacy and Pharmacology 71:5, pages 788-796.
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Tingyu Yang, Yani Liu, Xixi Huang, Rui Zhang, Chunxiao Yang, Jiali Zhou, Yu Zhang, Jing Wan & Shaojun Shi. (2018) Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats. Molecular Medicine Reports.
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Chung-Ping Yu, Ching-Ya Huang, Shiuan-Pey Lin & Yu-Chi Hou. (2018) Activation of P-glycoprotein and CYP 3A by Coptidis Rhizoma in vivo : Using cyclosporine as a probe substrate in rats. Journal of Food and Drug Analysis 26:2, pages S125-S132.
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Meng-Syuan Yang, Chung-Ping Yu, Ching-Ya Huang, Pei-Dawn Lee Chao, Shiuan-Pey Lin & Yu-Chi Hou. (2017) Aloe activated P-glycoprotein and CYP 3A: a study on the serum kinetics of aloe and its interaction with cyclosporine in rats. Food & Function 8:1, pages 315-322.
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