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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 9
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General Xenobiochemistry

Absorption characteristic of paeoniflorin-6′-O-benzene sulfonate (CP-25) in in situ single-pass intestinal perfusion in rats

Xiao-Dan YangInstitute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Hefei, China
,
Chun WangInstitute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Hefei, China
,
Peng ZhouInstitute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Hefei, China
,
Jun YuInstitute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Hefei, China
,
James AsensoInstitute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Hefei, China
,
Yong MaInstitute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Hefei, ChinaCorrespondence[email protected]
&
Wei WeiInstitute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Hefei, ChinaCorrespondence[email protected]
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Pages 775-783 | Received 24 Sep 2015, Accepted 15 Nov 2015, Published online: 29 Dec 2015

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Chengying Shen, Baode Shen, Junjun Zhu, Jing Wang, Hailong Yuan & Xiaofang Li. (2021) Glycyrrhizic acid-based self-assembled micelles for improving oral bioavailability of paeoniflorin. Drug Development and Industrial Pharmacy 47:2, pages 207-214.
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Chun Wang, Jun Yuan, Ling Ling Zhang & Wei Wei. (2016) Pharmacokinetic comparisons of Paeoniflorin and Paeoniflorin-6'O-benzene sulfonate in rats via different routes of administration. Xenobiotica 46:12, pages 1142-1150.
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Articles from other publishers (23)

Ning Xiao, Feng Xiao, Jinzhang Gao, Zhengkun Xu, Qianlei Wang, Jiajie Kuai, Wei Wei & Chun Wang. (2021) Effects of paeoniflorin‐6′‐O‐benzene sulfonate on the pharmacokinetics, excretion and tissue distribution of leflunomide in rats. Basic & Clinical Pharmacology & Toxicology 130:3, pages 364-374.
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Ling ZhangYihang ZhangJihong Pan. (2021) Immunopathogenic mechanisms of rheumatoid arthritis and the use of anti-inflammatory drugs. Intractable & Rare Diseases Research 10:3, pages 154-164.
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Chenchen Han, Yifan Li, Yuwen Zhang, Yang Wang, Dongqian Cui, Tingting Luo, Yu Zhang, Qian Liu, Hao Li, Chun Wang, Dexiang Xu, Yang Ma & Wei Wei. (2021) Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats. Acta Pharmaceutica Sinica B 11:7, pages 1835-1852.
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Xiao‐Yu Cai, Jing‐Ru Ge, Li Xu, Fa‐Qin Liang, Yue Zhu, Yu Tai, Xian‐Zheng Zhang, Jin‐Ling Shu, Dan Mei, Le Han, Chen Wang, Xiao‐Yu Tang, Ling‐Ling Zhang & Wei Wei. (2020) Paeoniflorin‐6′‐o‐benzene sulfonate ( CP ‐25) improves vasculitis through inhibiting IL‐17A / JAK / STAT3 signaling pathway in endothelial cells of HFD CIA rats . Phytotherapy Research 35:2, pages 1033-1047.
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Xue-zhi Yang & Wei Wei. (2020) CP-25, a compound derived from paeoniflorin: research advance on its pharmacological actions and mechanisms in the treatment of inflammation and immune diseases. Acta Pharmacologica Sinica 41:11, pages 1387-1394.
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Jing Zhang, Yang Liu, Ming Long, Jun Li, Weikun Zhao & Qiang Su. (2020) Inhibitory effect of CP-25 on intimal formation and vascular hyperplasia via suppression of GRK2/ERK1/2/EVI1 signaling. Archives of Biochemistry and Biophysics 694, pages 108601.
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Yongjing Xiang, Qing Zhang, Shujun Wei, Cong Huang, Zhengsheng Li & Yongxiang Gao. (2020) Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities . Journal of Pharmacy and Pharmacology 72:4, pages 483-495.
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Chen-Chen Han, Qian Liu, Yu Zhang, Yi-Fan Li, Dong-Qian Cui, Ting-Ting Luo, Yu-Wen Zhang, Xin-Ming Wang, Chun Wang, Yang Ma & Wei Wei. (2020) CP-25 inhibits PGE2-induced angiogenesis by down-regulating EP4/AC/cAMP/PKA-mediated GRK2 translocation. Clinical Science 134:3, pages 331-347.
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Hao Tang, Yi-jin Wu, Feng Xiao, Bin Wang, James Asenso, Yong Wang, Wei Sun, Chun Wang & Wei Wei. (2019) Regulation of CP-25 on P-glycoprotein in synoviocytes of rats with adjuvant arthritis. Biomedicine & Pharmacotherapy 119, pages 109432.
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Min Zhang, Mei Gao, Jinyu Chen, Lihua Song & Wei Wei. (2019) CP-25 exerts anti-angiogenic effects on a rat model of adjuvant-induced arthritis by promoting GRK2-induced downregulation of CXCR4-ERK1/2 signaling in endothelial cells. Molecular Medicine Reports.
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Mingyi Zhao, Peng Zhou, Jun Yu, Asenso James, Feng Xiao, Chun Wang & Wei Wei. (2018) The tissue distribution and excretion study of paeoniflorin-6′-O-benzene sulfonate (CP-25) in rats. Inflammopharmacology 27:5, pages 969-974.
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Jin-ling Shu, Xian-zheng Zhang, Le Han, Feng Zhang, Yu-jing Wu, Xiao-yu Tang, Chen Wang, Yu Tai, Qing-tong Wang, Jing-yu Chen, Yan Chang, Hua-xun Wu, Ling-ling Zhang & Wei Wei. (2018) Paeoniflorin-6′-O-benzene sulfonate alleviates collagen-induced arthritis in mice by downregulating BAFF-TRAF2-NF-κB signaling: comparison with biological agents. Acta Pharmacologica Sinica 40:6, pages 801-813.
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James Asenso, Jun Yu, Feng Xiao, Mingyi Zhao, Jian Wang, Yijin Wu, Chun Wang & Wei Wei. (2019) Methotrexate improves the anti-arthritic effects of Paeoniflorin-6'-O-benzene sulfonate by enhancing its pharmacokinetic properties in adjuvant-induced arthritis rats. Biomedicine & Pharmacotherapy 112, pages 108644.
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Jiajie Tu, Yawei Guo, Wenming Hong, Yilong Fang, Dafei Han, Pengying Zhang, Xinming Wang, Heinrich Körner & Wei Wei. (2019) The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6′-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases. Frontiers in Pharmacology 10.
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Meng Liu, Jie Yuan, Wen-juan Hu, Chang-qiang Ke, Yi-fan Zhang, Yang Ye, Da-fang Zhong, Guang-rong Zhao, Sheng Yao & Jia Liu. (2018) Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration. Acta Pharmacologica Sinica 40:2, pages 288-296.
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Xuezhi Yang, Yingjie Zhao, Xiaoyi Jia, Chun Wang, Yujing Wu, Lingling Zhang, Yan Chang & Wei Wei. (2019) CP-25 combined with MTX/ LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation. Biomedicine & Pharmacotherapy 110, pages 834-843.
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Yi-jin Wu, Ming-yi Zhao, Jian Wang, Hao Tang, Bin Wang, Feng Xiao, Li-hua Liu, Yun-fang Zhang, Ai-wu Zhou, Chun Wang & Wei Wei. (2018) Absorption and efflux characteristics of CP-25 in plasma and peripheral blood mononuclear cells of rats by UPLC-MS/MS. Biomedicine & Pharmacotherapy 108, pages 1651-1657.
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Fang Gu, Shixia Xu, Pengying Zhang, Xiaoyun Chen, Yujing Wu, Chun Wang, Mei Gao, Min Si, Xinming Wang, Korner Heinrich, Huaxun Wu & Wei Wei. (2018) CP-25 Alleviates Experimental Sjögren's Syndrome Features in NOD/Ltj Mice and Modulates T Lymphocyte Subsets. Basic & Clinical Pharmacology & Toxicology 123:4, pages 423-434.
Crossref
Jingyu Chen, Ying Wang, Huaxun Wu, Shangxue Yan, Yan Chang & Wei Wei. (2018) A Modified Compound From Paeoniflorin, CP-25, Suppressed Immune Responses and Synovium Inflammation in Collagen-Induced Arthritis Mice. Frontiers in Pharmacology 9.
Crossref
Yang Wang, Chen-chen Han, Dongqian Cui, Ting-ting Luo, Yifan Li, Yuwen Zhang, Yang Ma & Wei Wei. (2018) Immunomodulatory Effects of CP-25 on Splenic T Cells of Rats with Adjuvant Arthritis. Inflammation 41:3, pages 1049-1063.
Crossref
E Zhang, Fulong Chu, Lixu Xu, Hao Liang, Shuliang Song & Aiguo Ji. (2018) Use of fluorescein isothiocyanate isomer I to study the mechanism of intestinal absorption of fucoidan sulfate in vivo and in vitro . Biopharmaceutics & Drug Disposition 39:6, pages 298-307.
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Feng Zhang, Jin-Ling Shu, Ying Li, Yu-Jing Wu, Xian-Zheng Zhang, Le Han, Xiao-Yu Tang, Chen Wang, Qing-Tong Wang, Jing-Yu Chen, Yan Chang, Hua-Xun Wu, Ling-Ling Zhang & Wei Wei. (2017) CP-25, a Novel Anti-inflammatory and Immunomodulatory Drug, Inhibits the Functions of Activated Human B Cells through Regulating BAFF and TNF-alpha Signaling and Comparative Efficacy with Biological Agents. Frontiers in Pharmacology 8.
Crossref
Jun Yu, Feng Xiao, James Asenso, Peng Zhou, Xiao-Dan Yang, Chun Wang & Wei Wei. (2016) Simultaneous determination of paeoniflorin-6′-O-benzene sulfonate (CP-25) and its active paeoniflorin (Pae) metabolite in rat plasma using UPLC-MS/MS: an application for pharmacokinetic studies. RSC Advances 6:114, pages 113209-113218.
Crossref

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