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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 10
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General Xenobiochemistry

Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors

Ken-Ichi UmeharaDepartment of Drug Metabolism and Pharmacokinetics, Integrated Drug Disposition Section, Novartis Institutes for BioMedical Research, Basel, Switzerland, Correspondence[email protected]
,
Markus ZollingerDepartment of Drug Metabolism and Pharmacokinetics, Integrated Drug Disposition Section, Novartis Institutes for BioMedical Research, Basel, Switzerland,
,
Elizabeth KigonduDepartment of Chemistry, University of Cape Town, Rondebosch, Cape Town, South Africa, and
,
Marc WitschiDepartment of Drug Metabolism and Pharmacokinetics, Integrated Drug Disposition Section, Novartis Institutes for BioMedical Research, Basel, Switzerland,
,
Claire JuifDepartment of Drug Metabolism and Pharmacokinetics, Integrated Drug Disposition Section, Novartis Institutes for BioMedical Research, Basel, Switzerland,
,
Felix HuthDepartment of Drug Metabolism and Pharmacokinetics, Integrated Drug Disposition Section, Novartis Institutes for BioMedical Research, Basel, Switzerland,
,
Hilmar SchillerDepartment of Drug Metabolism and Pharmacokinetics, Integrated Drug Disposition Section, Novartis Institutes for BioMedical Research, Basel, Switzerland,
,
Kelly ChibaleDepartment of Chemistry, University of Cape Town, Rondebosch, Cape Town, South Africa, and ;Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, Cape Town, South Africa
&
Gian CamenischDepartment of Drug Metabolism and Pharmacokinetics, Integrated Drug Disposition Section, Novartis Institutes for BioMedical Research, Basel, Switzerland,
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Pages 862-867 | Received 21 Oct 2015, Accepted 15 Dec 2015, Published online: 18 Feb 2016

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Peter Gorycki, Mindy Magee, Peter Ackerman, Xiusheng Miao & Katy Moore. (2022) Pharmacokinetics, metabolism and excretion of radiolabeled fostemsavir administered with or without ritonavir in healthy male subjects. Xenobiotica 52:6, pages 541-554.
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Joshua L. Johnson, Jiansheng Huang, Michael Rooney & Chungang Gu. (2022) Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes. Xenobiotica 52:2, pages 105-112.
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Nikhilesh V. Dhuria, Bianka Haro, Amit Kapadia, Khadjia A. Lobo, Bernice Matusow, Mary A. Schleiff, Christina Tantoy & Jasleen K. Sodhi. (2021) Recent developments in predicting CYP-independent metabolism. Drug Metabolism Reviews 53:2, pages 188-206.
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Yuli Qian, Philip W. Melchert & John S. Markowitz. (2022) Involvement of esterases in the pulmonary metabolism of beclomethasone dipropionate and the potential influence of cannabis use. Chemico-Biological Interactions 368, pages 110228.
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Li Di. (2019) The Impact of Carboxylesterases in Drug Metabolism and Pharmacokinetics. Current Drug Metabolism 20:2, pages 91-102.
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Li-Wei Zou, Tong-Yi Dou, Ping Wang, Wei Lei, Zi-Miao Weng, Jie Hou, Dan-Dan Wang, Yi-Ming Fan, Wei-Dong Zhang, Guang-Bo Ge & Ling Yang. (2017) Structure-Activity Relationships of Pentacyclic Triterpenoids as Potent and Selective Inhibitors against Human Carboxylesterase 1. Frontiers in Pharmacology 8.
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Dan-Dan Wang, Li-Wei Zou, Qiang Jin, Jie Hou, Guang-Bo Ge & Ling Yang. (2017) Recent progress in the discovery of natural inhibitors against human carboxylesterases. Fitoterapia 117, pages 84-95.
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R. S. Foti & D. K. Dalvie. (2016) Cytochrome P450 and Non-Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics. Drug Metabolism and Disposition 44:8, pages 1229-1245.
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