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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 12
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Animal Pharmacokinetics and Metabolism

Pharmacokinetic comparisons of Paeoniflorin and Paeoniflorin-6'O-benzene sulfonate in rats via different routes of administration

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Pages 1142-1150 | Received 29 Oct 2015, Accepted 29 Jan 2016, Published online: 21 Mar 2016

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Chengying Shen, Baode Shen, Junjun Zhu, Jing Wang, Hailong Yuan & Xiaofang Li. (2021) Glycyrrhizic acid-based self-assembled micelles for improving oral bioavailability of paeoniflorin. Drug Development and Industrial Pharmacy 47:2, pages 207-214.
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Articles from other publishers (28)

Xiaoya Li, Changxin Sun, Jingyi Zhang, Lanqing Hu, Zongliang Yu, Xiaonan Zhang, Zeping Wang, Jiye Chen, Min Wu & Longtao Liu. (2023) Protective effects of paeoniflorin on cardiovascular diseases: A pharmacological and mechanistic overview. Frontiers in Pharmacology 14.
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Shaoshan Zhang, Jun-zhang Qu-Bie, Ming-kang Feng, A-xiang Qu-Bie, Yanfei Huang, Zhi-feng Zhang, Xin-jia Yan & Yuan Liu. (2023) Illuminating the biosynthesis pathway genes involved in bioactive specific monoterpene glycosides in Paeonia veitchii Lynch by a combination of sequencing platforms. BMC Genomics 24:1.
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Dominik Langer, Dariusz T. Mlynarczyk, Jolanta Dlugaszewska & Ewa Tykarska. (2023) Potential of glycyrrhizic and glycyrrhetinic acids against influenza type A and B viruses: A perspective to develop new anti-influenza compounds and drug delivery systems. European Journal of Medicinal Chemistry 246, pages 114934.
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Meichen Zhou, Shining Yin, Mingming Yu, Aiying Wu, Cong Wang & Jingguang Lu. (2022) Determination of Berberine Hydrochloride and Total Glucosides of Paeony by 1H NMR for Quality Control of Fufang Huangliansu Commercial Products. Revista Brasileira de Farmacognosia 32:5, pages 812-818.
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Ning Xiao, Feng Xiao, Jinzhang Gao, Zhengkun Xu, Qianlei Wang, Jiajie Kuai, Wei Wei & Chun Wang. (2021) Effects of paeoniflorin‐6′‐O‐benzene sulfonate on the pharmacokinetics, excretion and tissue distribution of leflunomide in rats. Basic & Clinical Pharmacology & Toxicology 130:3, pages 364-374.
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Huaxun Wu, Xiaoyun Chen, Fang Gu, Pengying Zhang, Shixia Xu, Qi Liu, Qiaolin Zhang, Xinming Wang, Chun Wang, Heinrich Körner & Wei Wei. (2021) CP-25 alleviates antigen-induced experimental Sjögren's syndrome in mice by inhibiting JAK1-STAT1/2-CXCL13 signaling and interfering with B-cell migration. Laboratory Investigation 101:8, pages 1084-1097.
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Chenchen Han, Yifan Li, Yuwen Zhang, Yang Wang, Dongqian Cui, Tingting Luo, Yu Zhang, Qian Liu, Hao Li, Chun Wang, Dexiang Xu, Yang Ma & Wei Wei. (2021) Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats. Acta Pharmaceutica Sinica B 11:7, pages 1835-1852.
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Xiao Wei, Yijin Wu, Hao Tang, Bin Wang, Yong Wang, Wei Sun, James Asenso, Feng Xiao & Chun Wang. (2021) CP-25 ameliorates methotrexate induced nephrotoxicity via improving renal apoptosis and methotrexate excretion. Journal of Pharmacological Sciences 146:1, pages 21-28.
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Seung-Hyun Jeong, Ji-Hun Jang, Da-Hwa Jung, Guk-Yeo Lee & Yong-Bok Lee. (2021) Pharmacokinetic Changes According to Single or Multiple Oral Administrations of Socheongryong-Tang to Rats: Presented as a Typical Example of Changes in the Pharmacokinetics Following Multiple Exposures to Herbal Medicines. Pharmaceutics 13:4, pages 478.
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Feng Jiao, Kevin Varghese, Shaoxun Wang, Yedan Liu, Hongwei Yu, George W. Booz, Richard J. Roman, Ruen Liu & Fan Fan. (2021) Recent Insights Into the Protective Mechanisms of Paeoniflorin in Neurological, Cardiovascular, and Renal Diseases. Journal of Cardiovascular Pharmacology 77:6, pages 728-734.
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Xue-zhi Yang & Wei Wei. (2020) CP-25, a compound derived from paeoniflorin: research advance on its pharmacological actions and mechanisms in the treatment of inflammation and immune diseases. Acta Pharmacologica Sinica 41:11, pages 1387-1394.
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Jing Zhang, Yang Liu, Ming Long, Jun Li, Weikun Zhao & Qiang Su. (2020) Inhibitory effect of CP-25 on intimal formation and vascular hyperplasia via suppression of GRK2/ERK1/2/EVI1 signaling. Archives of Biochemistry and Biophysics 694, pages 108601.
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Yan-Xi Zhou, Xiao-Hong Gong, Hong Zhang & Cheng Peng. (2020) A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects. Biomedicine & Pharmacotherapy 130, pages 110505.
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Chaoyin Wu, Benyue Li, Yi Zhang, Tingting Chen, Chuangrong Chen, Wei Jiang, Qi Wang & Tongkai Chen. (2020) Intranasal delivery of paeoniflorin nanocrystals for brain targeting. Asian Journal of Pharmaceutical Sciences 15:3, pages 326-335.
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Chen-Chen Han, Qian Liu, Yu Zhang, Yi-Fan Li, Dong-Qian Cui, Ting-Ting Luo, Yu-Wen Zhang, Xin-Ming Wang, Chun Wang, Yang Ma & Wei Wei. (2020) CP-25 inhibits PGE2-induced angiogenesis by down-regulating EP4/AC/cAMP/PKA-mediated GRK2 translocation. Clinical Science 134:3, pages 331-347.
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Hao Tang, Yi-jin Wu, Feng Xiao, Bin Wang, James Asenso, Yong Wang, Wei Sun, Chun Wang & Wei Wei. (2019) Regulation of CP-25 on P-glycoprotein in synoviocytes of rats with adjuvant arthritis. Biomedicine & Pharmacotherapy 119, pages 109432.
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Min Zhang, Mei Gao, Jinyu Chen, Lihua Song & Wei Wei. (2019) CP-25 exerts anti-angiogenic effects on a rat model of adjuvant-induced arthritis by promoting GRK2-induced downregulation of CXCR4-ERK1/2 signaling in endothelial cells. Molecular Medicine Reports.
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Mingyi Zhao, Peng Zhou, Jun Yu, Asenso James, Feng Xiao, Chun Wang & Wei Wei. (2018) The tissue distribution and excretion study of paeoniflorin-6′-O-benzene sulfonate (CP-25) in rats. Inflammopharmacology 27:5, pages 969-974.
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Jin-ling Shu, Xian-zheng Zhang, Le Han, Feng Zhang, Yu-jing Wu, Xiao-yu Tang, Chen Wang, Yu Tai, Qing-tong Wang, Jing-yu Chen, Yan Chang, Hua-xun Wu, Ling-ling Zhang & Wei Wei. (2018) Paeoniflorin-6′-O-benzene sulfonate alleviates collagen-induced arthritis in mice by downregulating BAFF-TRAF2-NF-κB signaling: comparison with biological agents. Acta Pharmacologica Sinica 40:6, pages 801-813.
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James Asenso, Jun Yu, Feng Xiao, Mingyi Zhao, Jian Wang, Yijin Wu, Chun Wang & Wei Wei. (2019) Methotrexate improves the anti-arthritic effects of Paeoniflorin-6'-O-benzene sulfonate by enhancing its pharmacokinetic properties in adjuvant-induced arthritis rats. Biomedicine & Pharmacotherapy 112, pages 108644.
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Xuezhi Yang, Yingjie Zhao, Xiaoyi Jia, Chun Wang, Yujing Wu, Lingling Zhang, Yan Chang & Wei Wei. (2019) CP-25 combined with MTX/ LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation. Biomedicine & Pharmacotherapy 110, pages 834-843.
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Jiajia Qian, Weiye Cheng, Caiyun Zhang, Lufeng Hong, Weidong Chen & Guoxi Li. (2019) Preparation, physicochemical characterization and pharmacokinetics of paeoniflorin-phospholipid complex. Bio-Medical Materials and Engineering 30:1, pages 11-22.
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Yi-jin Wu, Ming-yi Zhao, Jian Wang, Hao Tang, Bin Wang, Feng Xiao, Li-hua Liu, Yun-fang Zhang, Ai-wu Zhou, Chun Wang & Wei Wei. (2018) Absorption and efflux characteristics of CP-25 in plasma and peripheral blood mononuclear cells of rats by UPLC-MS/MS. Biomedicine & Pharmacotherapy 108, pages 1651-1657.
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Fang Gu, Shixia Xu, Pengying Zhang, Xiaoyun Chen, Yujing Wu, Chun Wang, Mei Gao, Min Si, Xinming Wang, Korner Heinrich, Huaxun Wu & Wei Wei. (2018) CP-25 Alleviates Experimental Sjögren's Syndrome Features in NOD/Ltj Mice and Modulates T Lymphocyte Subsets. Basic & Clinical Pharmacology & Toxicology 123:4, pages 423-434.
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Jingyu Chen, Ying Wang, Huaxun Wu, Shangxue Yan, Yan Chang & Wei Wei. (2018) A Modified Compound From Paeoniflorin, CP-25, Suppressed Immune Responses and Synovium Inflammation in Collagen-Induced Arthritis Mice. Frontiers in Pharmacology 9.
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Uzma Saqib, Sutripta Sarkar, Kyoungho Suk, Owais Mohammad, Mirza S. Baig & Rajkumar Savai. (2018) Phytochemicals as modulators of M1-M2 macrophages in inflammation. Oncotarget 9:25, pages 17937-17950.
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Yu-jing Wu, Heng-shi Chen, Wen-sheng Chen, Jin Dong, Xiao-jie Dong, Xing Dai, Qiong Huang & Wei Wei. (2018) CP-25 Attenuates the Activation of CD4+ T Cells Stimulated with Immunoglobulin D in Human. Frontiers in Pharmacology 9.
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Yang Wang, Chen-chen Han, Dongqian Cui, Yifan Li, Yang Ma & Wei Wei. (2017) Is macrophage polarization important in rheumatoid arthritis?. International Immunopharmacology 50, pages 345-352.
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