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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 12
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Clinical Pharmacokinetics and Metabolism

Metabolite profiling of 14C-omacetaxine mepesuccinate in plasma and excreta of cancer patients

Cynthia M. NijenhuisDepartment of Pharmacy and Pharmacology, Antoni Van Leeuwenhoek/The Netherlands Cancer Institute and MC Slotervaart, Amsterdam, The Netherlands, Correspondence[email protected]
,
Luc LucasDepartment of Pharmacy and Pharmacology, Antoni Van Leeuwenhoek/The Netherlands Cancer Institute and MC Slotervaart, Amsterdam, The Netherlands,
,
Hilde RosingDepartment of Pharmacy and Pharmacology, Antoni Van Leeuwenhoek/The Netherlands Cancer Institute and MC Slotervaart, Amsterdam, The Netherlands,
,
Philmore Robertson JrNonclinical DMPK, Teva Branded Pharmaceutical R&D, Inc., West Chester, PA, USA,
,
Edward T. HellriegelNonclinical DMPK, Teva Branded Pharmaceutical R&D, Inc., West Chester, PA, USA,
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Jan H. M. SchellensDivision of Clinical Pharmacology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands and ;Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
&
and Jos H. BeijnenDepartment of Pharmacy and Pharmacology, Antoni Van Leeuwenhoek/The Netherlands Cancer Institute and MC Slotervaart, Amsterdam, The Netherlands, ;Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
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Pages 1122-1132 | Received 14 Jan 2016, Accepted 05 Feb 2016, Published online: 21 Mar 2016

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C. M. Nijenhuis, J. H. M. Schellens & J. H. Beijnen. (2016) Regulatory aspects of human radiolabeled mass balance studies in oncology: concise review. Drug Metabolism Reviews 48:2, pages 266-280.
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Alessandro Pedretti, Angelica Mazzolari, Giulio Vistoli & Bernard Testa. (2018) MetaQSAR: An Integrated Database Engine to Manage and Analyze Metabolic Data. Journal of Medicinal Chemistry 61:3, pages 1019-1030.
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Pooja Sukhdev Dhurjad, Vamsi Krishna Marothu & Rajeshwari Rathod. (2017) Post-acquisition data mining techniques for LC–MS/MS-acquired data in drug metabolite identification. Bioanalysis 9:16, pages 1265-1278.
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Cynthia M. Nijenhuis, Edward Hellriegel, Jos H. Beijnen, Diane Hershock, Alwin D. R. Huitema, Luc Lucas, Marja Mergui-Roelvink, Mihaela Munteanu, Laura Rabinovich-Guilatt, Philmore RobertsonJr.Jr., Hilde Rosing, Ofer Spiegelstein & Jan H. M. Schellens. (2016) Pharmacokinetics and excretion of 14C-omacetaxine in patients with advanced solid tumors. Investigational New Drugs 34:5, pages 565-574.
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