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Xenobiotica
the fate of foreign compounds in biological systems
Volume 47, 2017 - Issue 1
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General Xenobiochemistry

In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes

Pei YuKey Laboratory of Drug Quality Control & Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing, China, ;State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, China, and
,
Hongcong QiuGuangxi Key Laboratory of Traditional Chinese Medicine Quality Standards (Guangxi Institute of Traditional Medical and Pharmaceutical Sciences), Nanning, China
,
Min WangKey Laboratory of Drug Quality Control & Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing, China, ;State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, China, and
,
Yuan TianKey Laboratory of Drug Quality Control & Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing, China, ;State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, China, and
,
Zunjian ZhangKey Laboratory of Drug Quality Control & Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing, China, ;State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, China, and Correspondence[email protected]
&
Rui SongKey Laboratory of Drug Quality Control & Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing, China, ;State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, China, and Correspondence[email protected]
Pages 11-19 | Received 04 Feb 2016, Accepted 06 Mar 2016, Published online: 06 Apr 2016

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Piao Zhou, Wei Shi, Xiao-Yan He, Quan-Yu Du, Fei Wang & Jing Guo. (2021) Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics. Pharmaceutical Biology 59:1, pages 1478-1487.
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Articles from other publishers (15)

Wen-Xian Dang, Rong Li, Jin-Yue Yang, Chang-Hu Xue, Qing-Rong Huang, Yu-Ming Wang & Tian-Tian Zhang. (2023) Effects of alcohol on digestion, absorption and metabolism of sea cucumber saponins in healthy mice. Food Science and Human Wellness, pages 1-15.
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Jialin Qu, Qiuyue Chen, Tianfu Wei, Ning Dou, Dong Shang & Dan Yuan. (2022) Systematic characterization of Puerariae Flos metabolites in vivo and assessment of its protective mechanisms against alcoholic liver injury in a rat model. Frontiers in Pharmacology 13.
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Lili Hu, Jue Wang, Xiaoge Zhao & Donghui Cai. (2022) Mechanism of saikogenin G against major depressive disorder determined by network pharmacology. Medicine 101:34, pages e30193.
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Qiwei Liu, Yunwen Xue, Jingjing Liu, Siqi Ren, Jie Xu, Jinni Yang, Yuanyue Xing, Zunjian Zhang & Rui Song. (2021) Saikosaponins and the deglycosylated metabolites exert liver meridian guiding effect through PXR/CYP3A4 inhibition. Journal of Ethnopharmacology 279, pages 114344.
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Ziqiang Wang, Bingcheng Wei, Tong Mu, Peng Xu & Biao Yu. (2021) Facile Synthesis of Saikosaponins. Molecules 26:7, pages 1941.
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Mengru Wu, Man Wang, Yangyang Zhang, Jinwei Zhou, Lili Xu, Guohua Xia, Zhipeng Yan, Yuping Shen & Huan Yang. (2020) Efficient and clean preparation of rare prosaikogenin D by enzymatic hydrolysis of saikosaponin B2 and response surface methodology optimization. Enzyme and Microbial Technology 142, pages 109690.
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Guoqiang Liu, Zunjian Zhang, Xiaoqing Lv, Shuyu Zhan, Baoue Ding, Xinji Yang & Qifeng Zhu. (2020) Z 0 ion from saikosaponins with 16 α‐OH and Y 0 ‐H 2 O from saikosaponins with 16 β‐OH may underlie their different dissociation patterns of [aglycone − H 2 O + H] + . Rapid Communications in Mass Spectrometry 34:8.
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Ruijia Fu, Jingjing Liu, Yunwen Xue, Zunjian Zhang & Rui Song. (2019) Effects of Animal Strain, Dose, and Cotreatment with Saikosaponin b2 on the Pharmacokinetics of Saikosaponin a in Rats. European Journal of Drug Metabolism and Pharmacokinetics 44:6, pages 827-836.
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Tingting Qin, Xinxin Fu, Jiayu Yu, Ruyi Zhang, Xueyang Deng, Qiang Fu, Zhanqiang Ma & Shiping Ma. (2019) Modification of GSK3β/β-catenin signaling on saikosaponins-d-induced inhibition of neural progenitor cell proliferation and adult neurogenesis. Toxicology 424, pages 152233.
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Yunwen Xue, Jingjing Liu, Ruijia Fu, Lei Gao, Xuping Yang, Zunjian Zhang & Rui Song. (2019) In vitro studies on the metabolism of saikogenins and the detection of their metabolites in authentic biosamples. Journal of Pharmaceutical and Biomedical Analysis 172, pages 295-301.
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Quan Chi, Ling Wang, Dong Xie & Xian Wang. (2019) Characterization of in vitro metabolism of focal adhesion kinase inhibitors by LC/MS/MS. Journal of Pharmaceutical and Biomedical Analysis 168, pages 163-173.
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Cuiyun Zou, Xiaohong Tan, Huaqun Ye, Zhenzhu Sun, Shu Chen, Qingying Liu, Minglei Xu, Chaoxia Ye & Anli Wang. (2018) The hepatoprotective effects of Radix Bupleuri extracts against D-galactosamine/lipopolysaccharide induced liver injury in hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀). Fish & Shellfish Immunology 83, pages 8-17.
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Jia Zhou, Hao Cai, Sicong Tu, Yu Duan, Ke Pei, Yangyang Xu, Jing Liu, Minjie Niu, Yating Zhang, Lin Shen & Qigang Zhou. (2018) Identification and Analysis of Compound Profiles of Sinisan Based on ‘Individual Herb, Herb-Pair, Herbal Formula’ before and after Processing Using UHPLC-Q-TOF/MS Coupled with Multiple Statistical Strategy. Molecules 23:12, pages 3128.
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Xiaojiaoyang Li, Xiaoyu Li, Nana Huang, Runping Liu & Rong Sun. (2018) A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins. Phytomedicine 50, pages 73-87.
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Qian-qian Zhang, Wan-qiu Huang, Yi-qiao Gao, Zhao-di Han, Wei Zhang, Zun-jian Zhang & Feng-guo Xu. (2018) Metabolomics Reveals the Efficacy of Caspase Inhibition for Saikosaponin D-Induced Hepatotoxicity. Frontiers in Pharmacology 9.
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