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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 3
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Research Article

Hydroxylation and Subsequent Glucuronide Conjugation of Desmethylimipramine in Rat Liver Microsomes

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Pages 205-212 | Received 29 Jun 1971, Published online: 15 Sep 2008

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Faith M. Williams, Robin H. Briant, C. T. Dollery & D. S. Davies. (1974) The Influence of the Route of Administration on Urinary Metabolites of Isoetharine. Xenobiotica 4:6, pages 345-353.
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E Maria Savenije-Chapel, Aalt Bast & Jan Noordhoek. (1983) Interaction of uridine 5‘-diphosphoglucuronic acid (UDPGA) with cytochrome P 450. Journal of Pharmacy and Pharmacology 35:8, pages 522-523.
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Shin-ichi Ikushiro, Masahiro Sahara, Yoshikazu Emi, Yoshiyasu Yabusaki & Takashi Iyanagi. (2004) Functional co-expression of xenobiotic metabolizing enzymes, rat cytochrome P450 1A1 and UDP-glucuronosyltransferase 1A6, in yeast microsomes. Biochimica et Biophysica Acta (BBA) - General Subjects 1672:2, pages 86-92.
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Janusz Z. Byczkowski & Teresa Gessner. (1987) Effects of superoxide generated in vitro on glucuronidation of benzo[a]pyrene metabolites by mouse liver microsomes. International Journal of Biochemistry 19:6, pages 531-537.
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E. Maria Savenije-Chapel, Aalt Bast & Jan Noordhoek. (1985) Inhibition of diazepam metabolism in microsomal-and perfused liver preparations of the rat by desmethyldiazepam, N-methyloxazepam and oxazepam. European Journal of Drug Metabolism and Pharmacokinetics 10:1, pages 15-20.
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M. H. Bickel. 1980. Psychotropic Agents. Psychotropic Agents 551 572 .
Philip Wiebkin, Gerald L. Parker, Jeffrey R. Fry & James W. Bridges. (1979) Effect of various metabolic inhibitors on biphenyl metabolism in isolated rat hepatocytes. Biochemical Pharmacology 28:22, pages 3315-3321.
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K. W. Bock. (1978) Increase of liver microsomal benzo(a)pyrene monooxygenase activity by subsequent glucuronidation. Naunyn-Schmiedeberg's Archives of Pharmacology 304:1, pages 77-79.
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H. Denk, R. Eckerstorfer & H.P. Rohr. (1977) The endoplasmic reticulum of the rat liver cell in experimental mechanical cholestasis. Correlated biochemical and ultrastructural-morphometric studies on structure and enzyme composition. Experimental and Molecular Pathology 26:2, pages 193-203.
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Marios Marselos, Matti Lang & Riitta Törrönen. (1976) Modifications of drug metabolism by disulfiram and diethyldithiocarbamate II. d-glucuronic acid pathway. Chemico-Biological Interactions 15:3, pages 277-287.
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Peter Moldéus, Helena Vadi & Margareta Berggren. (2009) Oxidative and Conjugative Metabolism of p –Nitroanisole and p –Nitrophenol in Isolated Rat Liver Cells . Acta Pharmacologica et Toxicologica 39:1, pages 17-32.
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Richard R. Erickson & Jordan L. Holtzman. (1976) Kinetic studies on the metabolism of ethylmorphine by isolated hepatocytes from adult rats. Biochemical Pharmacology 25:13, pages 1501-1506.
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D.H. Hutson. (1976) Comparative metabolism of dieldrin in the rat (CFE) and in two strains of mouse (CF1 and LACG). Food and Cosmetics Toxicology 14:6, pages 577-591.
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H. Paul, A. Illing, Stefan Kunke & Karl J. Netter. (1974) On the spectral intermediate at 440 nm formed during mixed function substrate oxidation. Biochemical Pharmacology 23:18, pages 2603-2616.
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M. H. Bickel & H. B�rner. (1974) Uptake, subcellular distribution, and transfer processes of imipramine and its metabolites formed in rat liver perfusion systems. Naunyn-Schmiedeberg's Archives of Pharmacology 284:4, pages 339-352.
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K. Minck, R. R. Schupp, H. P. A. Illing, G. F. Kahl & K. J. Netter. (1973) Interrelationship between demethylation of p-nitroanisole and conjugation of p-nitrophenol in rat liver. Naunyn-Schmiedeberg's Archives of Pharmacology 279:4, pages 347-360.
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Christer von Bahr, Eino Hietanen & Hans Glaumann. (1972) Oxidation and Glucuronidation of Certain Drugs in Various Subcellular Fractions of Rat Liver: Binding of Desmethylimipramine and Hexobarbital to Cytochrome P-450 and Oxidation and Glucuronidation of Desmethylimipramine, Aminopyrine, p-Nitrophenol and 1-Na. Acta Pharmacologica et Toxicologica 31:1-2, pages 107-120.
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