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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 3
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Research Article

Chlordiazepoxide Metabolism as Related to the Reduction in the Aggressive Behaviour of Cynomolgus Primates

Claude B. Coutinho Department of Clinical Pharmacology, Hoffmann-La Roche Inc., Nutley, New Jersey, 07110, USA
,
Margaret King Department of Clinical Pharmacology, Hoffmann-La Roche Inc., Nutley, New Jersey, 07110, USA
,
John J. Carbone Department of Clinical Pharmacology, Hoffmann-La Roche Inc., Nutley, New Jersey, 07110, USA
,
John E. Manning Department of Clinical Pharmacology, Hoffmann-La Roche Inc., Nutley, New Jersey, 07110, USA
,
Edward Boff Department of Clinical Pharmacology, Hoffmann-La Roche Inc., Nutley, New Jersey, 07110, USA
&
Theodore Crews Department of Clinical Pharmacology, Hoffmann-La Roche Inc., Nutley, New Jersey, 07110, USA
Pages 287-301 | Received 17 Aug 1971, Published online: 15 Sep 2008

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R. Girkin, G. A. Baldock, L. F. Chasseaud, M. Hümpel, D. R. Hawkins & B. C. Mayo. (1980) The absorption, distribution and excretion of [14C]lormetazepam in dogs, rabbits, rats and rhesus monkeys. Xenobiotica 10:6, pages 401-411.
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Claude B. Coutinho, Joyce A. Cheripko, John J. Carbone, John E. Manning & Edward Boff. (1973) Behavioural Changes in Primates and Diazepam Metabolism. Xenobiotica 3:10, pages 681-690.
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Articles from other publishers (8)

D. Caroline Blanchard, Kevin Hori, R. John Rodgers, Colin A. Hendrie & Robert J. Blanchard. (1989) Attenuation of defensive threat and attack in wild rats (Rattus rattus) by benzodiazepines. Psychopharmacology 97:3, pages 392-401.
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Klaus A. Miczek. 1987. Handbook of Psychopharmacology. Handbook of Psychopharmacology 183 328 .
Arthur W.K. Chan & Philip H. Heubusch. (1982) Relationship of brain cyclic nucleotide levels and the interaction of ethanol with chlordiazepoxide. Biochemical Pharmacology 31:1, pages 85-89.
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W. Haefely, L. Pieri, P. Polc & R. Schaffner. 1981. Psychotropic Agents. Psychotropic Agents 13 262 .
G. R. WILKINSON. (2008) The effects of liver disease and aging on the disposition of diazepam, chlordiazepoxide, oxazepam and lorazepam in man. Acta Psychiatrica Scandinavica 58:S274, pages 56-74.
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John M. Clifford. (1977) Drug disposition and effect in sub-human primates used in pharmacology. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 57:1, pages 1-15.
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Anthony J. Glazko. (2007) Antiepileptic Drugs: Biotransformation, Metabolism, and Serum Half‐Life. Epilepsia 16:2, pages 367-391.
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LOWELL O. RANDALL, WILLIAM SCHALLEK, LEO H. STERNBACH & ROBERT Y. NING. 1974. Psychopharmacological Agents. Psychopharmacological Agents 175 281 .

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