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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 4-5
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Research Article

N-Hydroxylation

H. Uehleke Institute of Pharmacology, University of Tübingen, Germany
Pages 327-338 | Received 01 Oct 1971, Published online: 14 Oct 2008

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Peter Hlavica. (2002) N-OXIDATIVE TRANSFORMATION OF FREE AND N-SUBSTITUTED AMINE FUNCTIONS BY CYTOCHROME P450 AS MEANS OF BIOACTIVATION AND DETOXICATION. Drug Metabolism Reviews 34:3, pages 451-477.
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T. G. Altunas & J. W. Gorrod. (1996) Effect of various potential inhibitors, activators and inducers on the N-oxidation of isomeric aromatic diazines in vitro using rabbit liver microsomal preparations. Xenobiotica 26:1, pages 9-15.
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J. M. Dady, S. P. Bradbury, A. D. Hoffman, M. M. Voit & D. L. Olson. (1991) Hepatic microsomal N-hydroxylation of aniline and 4-chloroaniline by rainbow trout (Onchorhyncus mykiss). Xenobiotica 21:12, pages 1605-1620.
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T. Inoue & K. Tanaka. (1990) N-Oxidation and N-demethylation of methylephedrine by rat-liver microsomes. Xenobiotica 20:3, pages 265-271.
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J. H. Boot, C. W. M. Van Holsteijn, W. Seinen & B. J. Blaauboer. (1989) Effects of sulphydryl reagents on the formation of the aniline metabolite 4-aminophenol and its sulphate and glucuronide conjugates in primary cultures of rat hepatocytes. Xenobiotica 19:11, pages 1267-1273.
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M. Schulz & A. Schmoldt. (1988) On the sulphoxidation of cimetidine and etintidine by rat and human liver microsomes. Xenobiotica 18:8, pages 983-989.
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J. W. Gorrod & N. J. Gooderham. (1987) The metabolism of N-benzyl-4-substituted anilines: factors influencing in vitro C- and N-oxidation. Xenobiotica 17:2, pages 165-177.
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Charlotte Ressler & MicheleM. Knapp. (1985) Liquid Chromatography of Oxidized Sulfanilamide Derivatives. Journal of Liquid Chromatography 8:8, pages 1445-1453.
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W. M. H. Heijbroek, D. F. Muggleton & D. V. Parke. (1984) Metabolism of the carbamate herbicide, asulam, in the rat. Xenobiotica 14:3, pages 235-247.
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Peter Hlavica & John W. Gorrod. (1982) Biological Oxidation of Nitrogen in Organic Compounds and Disposition of N-Oxidized Product. Critical Reviews in Biochemistry 12:1, pages 39-101.
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Björn Lindeke. (1982) The Non-and Postenzymatic Chemistry of N-Oxygenated Molecules. Drug Metabolism Reviews 13:1, pages 71-121.
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Sonja Poplawski-Tabarelli & H. Uehleke. (1982) Inhibition of microsomal drug oxidations by aliphatic halohydrocarbons: correlation with vapour pressure. Xenobiotica 12:1, pages 55-61.
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R. Braun, U. Greeff & K. J. Netter. (1980) Indications for nitrosamide formation from the mushroom poison gyromitrin by rat liver microsomes. Xenobiotica 10:7-8, pages 557-564.
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M. K. Baldwin & D. H. Hutson. (1980) The metabolism of 3-chloro-4-fluoro-aniline in dog and rat. Xenobiotica 10:2, pages 135-144.
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J. W. Gorrod & L. A. Damani. (1979) The effect of various potential inhibitors, activators and inducers on the N-oxidation of 3-substituted pyridines in vitro. Xenobiotica 9:4, pages 219-226.
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Jeffrey R. Fry, Philip Wiebkin, John Kao, Carol A. Jones, Jennie Gwynn & James W. Bridges. (1978) A Comparison of Drug-Metabolizing Capability in Isolated Viable Rat Hepatocytes and Renal Tubule Fragments. Xenobiotica 8:2, pages 113-120.
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Lawrence L. Poulsen, Bettie Sue Siler Masters & Daniel M. Ziegler. (1976) Mechanism of 2-Naphthylamine Oxidation Catalysed by Pig Liver Microsomes. Xenobiotica 6:8, pages 481-498.
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J. W. Gorrod, D. J. Temple & A. H. Beckett. (1975) The Metabolism of N-Ethyl-N-methylaniline by Rabbit Liver Microsomes: The Measurement of Metabolites by Gas-liquid Chromatography. Xenobiotica 5:8, pages 453-463.
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Michael R. Franklin. (1974) Inhibition of the Metabolism of N-Substituted Amphetamines by SKF 525-A and Related Compounds. Xenobiotica 4:3, pages 143-150.
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Robin H. Briant, Elaine W. Blackwell, Faith M. Williams, Donald S. Davies & Colin T. Dollery. (1973) The Metabolism of Sympathomimetic Bronchodilator Drugs by the Isolated Perfused Dog Lung. Xenobiotica 3:12, pages 787-799.
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H. Uehleke, K. H. Hellmer & S. Tabarelli. (1973) Binding of 14C-Carbon Tetrachloride to Microsomal Proteins in vitro and Formation of CHCl3 by Reduced Liver Microsomes. Xenobiotica 3:1, pages 1-11.
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T. Matsushima & J. H. Weisburger. (1972) Effect of Carbon Monoxide or of 3-Aminotriazole on C- and N-Hydroxylation of the Carcinogen N-2-Fluorenylacetamide by Liver Microsomes of Hamsters Pretreated with 3-Methylcholanthrene. Xenobiotica 2:5, pages 423-430.
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