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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 4-5
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Research Article

The Role of Nitrogen Oxidation in the Excretion of Drugs and Foreign Compounds

Pages 399-418 | Received 01 Oct 1971, Published online: 14 Oct 2008

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S. K. Lee, M. J. Kang, C. Jin, M. K. In, D.-H. Kim & H. H. Yoo. (2009) Flavin-containing monooxygenase 1-catalysed N,N-dimethylamphetamine N-oxidation. Xenobiotica 39:9, pages 680-686.
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M. Katagi, M. Tatsuno, H. Tsutsumi, A. Miki, T. Kamata, H. Nishioka, K. Nakajima, M. Nishikawa & H. Tsuchihashi. (2002) Urinary excretion of selegiline N -oxide, a new indicator for selegiline administration in man. Xenobiotica 32:9, pages 823-831.
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T. J. Jaworski, E. M. Hawes, J. W. Hubbard, G. McKay & K. K. Midha. (1991) The metabolites of chlorpromazine N-oxide in rat bile. Xenobiotica 21:11, pages 1451-1459.
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D. M. Ziegler. (1988) Flavin-containing monooxygenases: Catalytic mechanism and substrate specificities. Drug Metabolism Reviews 19:1, pages 1-32.
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T. Inoue & S. Suzuki. (1987) The metabolism of dimethylamphetamine in rat and man. Xenobiotica 17:8, pages 965-971.
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Peter Hlavica & John W. Gorrod. (1982) Biological Oxidation of Nitrogen in Organic Compounds and Disposition of N-Oxidized Product. Critical Reviews in Biochemistry 12:1, pages 39-101.
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Jerome Edelson & David P. Benziger. (1980) Disposition of a Series of Tetrahydrocarbazoles. Drug Metabolism Reviews 11:2, pages 263-289.
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D. Kirkpatrick, K. T. Weston, D. R. Hawkins, L. F. Chasseaud & L. F. Elsom. (1977) Identification of an N-Oxide as the Major Metabolite of the Analgesic O-(Diethylaminoethyl)-4-Chlorobenz-aldoxime Hydrochloride in Dogs. Xenobiotica 7:12, pages 747-755.
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Articles from other publishers (21)

Xin Zhang, Ming Jin, Yuping Liu, Qimingxing Chen, Luqin Si, Gao Li, Yonghui Zhang & Jiangeng Huang. (2018) Oral Bioavailability of Kinsenoside in Beagle Dogs Measured by LC-MS/MS: Improvement of Ex Vivo Stability of a Lactone-Containing Compound. Pharmaceutics 10:3, pages 87.
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Sangkyu Lee, Hye Hyun Yoo, Moon Kyo In, Changbae Jin & Dong Hyun Kim. (2013) Stereoselectivity in the cytochrome P450-dependent N-demethylation and flavin monooxygenase-dependent N-oxidation of N,N-dimethylamphetamine. Archives of Pharmacal Research 36:11, pages 1385-1391.
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Tapan K. Majumdar. 2013. Handbook of LC-MS Bioanalysis. Handbook of LC-MS Bioanalysis 461 470 .
A H Beckett & P M Bëlanger. (1974) Metabolism of chlorphentermine and phentermine in man to yield hydroxylamino, C -nitroso- and nitro-compounds . Journal of Pharmacy and Pharmacology 26:3, pages 205-206.
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Sang Kyu Lee, So-Hee Kim, Ho Jun Kim, Hye Hyun Yoo, Oh Seung Kwon, Moon Kyo In, Changbae Jin, Dong Hyun Kim & Jaeick Lee. (2010) Simultaneous qualitative and quantitative method using liquid chromatography selected reaction monitoring-triggered quantitation-enhanced data-dependent tandem mass spectrometry for the identification and classification of amphetamine-type stimulant abuse. Rapid Communications in Mass Spectrometry 24:21, pages 3139-3145.
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Jin Young Kim, Jae Chul Cheong, Beom Jun Ko, Sang Kyu Lee, Hye Hyun Yoo, Changbae Jin & Moon Kyo In. (2008) Simultaneous determination of methamphetamine, 3,4-methylenedioxy-N-methylamphetamine, 3,4-methylenedioxy-N-ethylamphetamine, N,N-dimethylamphetamine, and their metabolites in urine by liquid chromatography-electrospray ionization-tandem mass spectrometry. Archives of Pharmacal Research 31:12, pages 1644-1651.
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Wing-Chi Cheng, Vincent King-Kuen Mok, Ka-Keung Chan & Ava Fung-man Li. (2007) A rapid and convenient LC/MS method for routine identification of methamphetamine/dimethylamphetamine and their metabolites in urine. Forensic Science International 166:1, pages 1-7.
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Motoyasu Sato, Minemasa Hida & Hisamitsu Nagase. (2002) Analysis of dimethylamphetamine and its metabolites in human urine by liquid chromatography–electrospray ionization–mass spectrometry with direct sample injection. Forensic Science International 128:3, pages 146-154.
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Ruri Kikura, Yuji Nakahara & Shigeo Kojima. (2000) Simultaneous determination of dimethylamphetamine and its metabolites in rat hair by gas chromatography–mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 741:2, pages 163-173.
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K. K. Midha, T. J. Jaworski, E. M. Hawes, G. McKay, J. W. Hubbard, M. Aravagiri & S. R. Marder. 1991. N-Oxidation of Drugs. N-Oxidation of Drugs 37 55 .
E. M. Hawes, T. J. Jaworski, K. K. Midha, G. McKay, J. W. Hubbard & E. D. Korchinski. 1991. N-Oxidation of Drugs. N-Oxidation of Drugs 263 286 .
A. Raisi & A. H. Beckett. (1986) Identification and quantitative analysis of phendimetrazine and some of its metabolites in biological fluidsIdentifizierung und quantitative Analyse von Phendimetrazin und einigen Metaboliten in biologischen Fl�ssigkeiten. Monatshefte f�r Chemie Chemical Monthly 117:8-9, pages 1047-1055.
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. 1984. Comprehensive Heterocyclic Chemistry. Comprehensive Heterocyclic Chemistry 673 731 .
L.A. Damani & D.E. Case. 1984. Comprehensive Heterocyclic Chemistry. Comprehensive Heterocyclic Chemistry 223 246 .
L.A. DAMANI. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 127 149 .
Madeline McComish, Itamar Bodek & Alan R. Branfman. (1980) Quantitation of the antineoplastic agent indicine-N-oxide in human plasma by differential pulse polarography. Journal of Pharmaceutical Sciences 69:6, pages 727-729.
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DANIEL M. ZIEGLER. 1980. Enzymatic Basis of Detoxication. Enzymatic Basis of Detoxication 201 227 .
Herbert A. H. Oelschläger, David J. Temple & Julia Iglesias‐Meier. (2006) Über den Mechanismus der oxidativen Abspaltung des Morpholins aus dem Lokalanästhetikum Fomocain. Archiv der Pharmazie 310:7, pages 579-587.
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J.W. GORROD & P. JENNER. 1975. 35 78 .
Dennis E. Drayer. (1974) Pathways of Drug Metabolism in Man. Medical Clinics of North America 58:5, pages 927-944.
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Charles F. Chesney & James R. Allen. (1973) Resistance of the guinea pig to pyrrolizidine alkaloid intoxication. Toxicology and Applied Pharmacology 26:3, pages 385-392.
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