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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 4-5
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Research Article

Bioreduction of Organic Nitrogen

Pages 469-481 | Received 01 Oct 1971, Published online: 14 Oct 2008

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Ian R. Rowland, Anthony K. Mallett & Alan Wise. (1985) The Effect of Diet on the Mammalian Gut Flora and Its Metabolic Activities. CRC Critical Reviews in Toxicology 16:1, pages 31-103.
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B. J. Blaauboer & C. W. M. Van Holsteijn. (1983) Formation and disposition of N-hydroxylated metabolites of aniline and nitrobenzene by isolated rat hepatocytes. Xenobiotica 13:5, pages 295-302.
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I. R. Rowland, A. K. Mallett, A. Wise & E. Bailey. (1983) Effect of dietary carrageenan and pectin on the reduction of nitro-compounds by the rat caecal microflora. Xenobiotica 13:4, pages 251-256.
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H. H. W. Thijssen & P. Th. Henderson. (1973) Interference of the Reduction of p-Nitrobenzoate in E. Coli by Nitrofurantoin. Xenobiotica 3:6, pages 399-407.
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Hasse Schröder & Anna K. Johansson. (1973) Redox Potential in Caecal Contents of the Rat and Azo Reduction of Salicyl-Azo-Sulphapyridine. Xenobiotica 3:4, pages 233-246.
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Hasse Schröder & Bengt E. Gustafsson. (1973) Azo Reduction of Salicyl-Azo-Sulphapyridine in Germ-free and Conventional Rats. Xenobiotica 3:4, pages 225-231.
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A H BeckettP M Bélanger. (1976) The microsomal N -oxidation of phentermine . Journal of Pharmacy and Pharmacology 28:9, pages 692-699.
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B. Kaymakçioglu, Ε. Οruç, Μ. Ulgen & S. Rollas. (1999) THE IN VITRO HEPATIC MICROSOMAL METABOLISM OF 3,5-DIMETHYL-4-(PHENYLAZO)-(1H)-PYRAZOLE IN RATS. Drug Metabolism and Drug Interactions 15:2-3.
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J. W. Gorrod & T. G. Altuntas. (1997) Comutagenesis-V: rapid conversion of 2-hydroxyl-amino-3-methylpyridine to 2-amino-3-methylpyridine by a hepatic S9 preparation. European Journal of Drug Metabolism and Pharmacokinetics 22:4, pages 341-344.
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BRUCE I. GAYNES & RICHARD G. FISCELLA. (1996) Biotransformation in Review: Applications in Ocular Disease and Drug Design. Journal of Ocular Pharmacology and Therapeutics 12:4, pages 527-539.
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R. W. Chadwick, S. E. George, M. J. Kohan, J. C. Allison, J. Chang, J. E. Long, M. C. Duffy, J. P. Dekker & L. R. Forehand. (2009) Effects of age, species difference, antibiotics and toxicants on intestinal enzyme activity and genotoxicity. Environmental Toxicology and Chemistry 12:8, pages 1339-1352.
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LENA B. BRATTSTEN. 1992. Herbivores: Their Interactions with Secondary Plant Metabolites. Herbivores: Their Interactions with Secondary Plant Metabolites 175 242 .
Robert W. Chadwick, Jerjang Chang, Linda R. Forehand, James E. Long & M.Catherine Duffy. (1990) Effect of lindane on intestinal nitroreductase, azoreductase, ?-glucuronidase, dechlorinase, and dehydrochlorinase activity. Pesticide Biochemistry and Physiology 38:1, pages 48-56.
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R.W. Chadwick, S.E. George, J. Chang, M.J. Kohan, J.P. Dekker, J.E. Long & M.C. Duffy. (1990) Comparative gastrointestinal enzyme activity and activation of the promutagen 2,6-dinitrotoluene in male CD-1 mice and male Fischer 344 rats. Cancer Letters 52:1, pages 13-19.
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Robert W. Chadwick, Jerjang Chang, Peter H. Gilligan, Linda R. Forehand, James E. Long & M.Catherine Duffy. (1990) Effect of lindane on nitroreductase and dechlorinase enzyme activity in the gastrointestinal tract. Toxicology Letters 50:2-3, pages 299-308.
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William J. Ehlhardt, Bernard B. BeaulieuJr.Jr. & Peter Goldman. (1987) Chemical and biological properties of acetyl derivatives of the hydroxylamino reduction products of metronidazole and dimetridazole. Biochemical Pharmacology 36:6, pages 931-935.
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M?nica Masana, Edith G.D. de Toranzo & Jos?A. Castro. (1984) Reductive metabolism and activation of benznidazole. Biochemical Pharmacology 33:7, pages 1041-1045.
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Peter C. Ruenitz & Jerome R. Bagley. (1983) Formation of benzophenone and α,α-diarylacetophenone metabolites of the antiestrogen nitromiphene (CI628) in the presence of rat cecal contents. Life Sciences 33:11, pages 1051-1056.
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Michael B. Mattammal, Terry V. Zenser & Bernard B. Davis. (1982) Mass spectrometry of 2-substituted-4-arylthiazoles: II-identification of microsomal nitroreduction product by mass spectrometry. Biological Mass Spectrometry 9:9, pages 376-380.
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Brion J. Gross, Richard V. Branchflower, Terrence R. Burke, David E. Lees & Lance R. Pohl. (1982) Bone marrow toxicity in vitro of chloramphenicol and its metabolites. Toxicology and Applied Pharmacology 64:3, pages 557-565.
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D.S. HEWICK. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 151 170 .
D. E. Schwartz & W. Hofheinz. 1982. Nitroimidazoles. Nitroimidazoles 91 104 .
Heinz W. Köchli, Bendicht Wermut & Jean-Pierre Von Wartburg. (1980) Characterization of a mitochondrial NADH-dependent nitro reductase from rat brain. Biochimica et Biophysica Acta (BBA) - Enzymology 616:2, pages 133-142.
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Stephen J. Rinkus & Marvin S. Legator. 1980. Chemical Mutagens. Chemical Mutagens 365 473 .
Garth Powis & Ingela Jansson. (1979) Stoichiometry of the mixed function oxidase. Pharmacology & Therapeutics 7:2, pages 297-311.
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R.T. WILLIAMS. 1978. Nutrition and Drug Interrelations. Nutrition and Drug Interrelations 303 318 .
Ronald P. Mason, Francis J. Peterson & Jordan L. Holtzman. (1977) The formation of an azo anion free radical metabolite during the microsomal azo reduction of sulfonazo III. Biochemical and Biophysical Research Communications 75:3, pages 532-540.
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L. A. Sternson. (1975) Detection of arylhydroxylamines as intermediates in the metabolic reduction of nitro compounds. Experientia 31:3, pages 268-270.
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Dennis E. Drayer. (1974) Pathways of Drug Metabolism in Man. Medical Clinics of North America 58:5, pages 927-944.
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G.M. Holder & S. Willox. (1973) Nitrobenzene reduction and reductive cleavage of azobenzenes in two species of arachnida. Life Sciences 13:4, pages 391-400.
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