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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 4-5
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Research Article

Some Factors Affecting the Conversion of Pyrrolizidine Alkaloids to N-Oxides and to Pyrrolic Derivatives in vitro

I. N. H. White MRC Toxicology Unit, Medical Research Council Laboratories, Woodmansterne Road, Carshalton, Surrey, UK
&
A. R. Mattocks MRC Toxicology Unit, Medical Research Council Laboratories, Woodmansterne Road, Carshalton, Surrey, UK
Pages 503-505 | Received 01 Oct 1971, Published online: 14 Oct 2008

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Peter Hlavica. (2002) N-OXIDATIVE TRANSFORMATION OF FREE AND N-SUBSTITUTED AMINE FUNCTIONS BY CYTOCHROME P450 AS MEANS OF BIOACTIVATION AND DETOXICATION. Drug Metabolism Reviews 34:3, pages 451-477.
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Peter Hlavica & John W. Gorrod. (1982) Biological Oxidation of Nitrogen in Organic Compounds and Disposition of N-Oxidized Product. Critical Reviews in Biochemistry 12:1, pages 39-101.
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J. W. Gorrod, D. J. Temple & A. H. Beckett. (1975) The Differentiation of N-Oxidation and N-Dealkylation of N-Ethyl-N-methylaniline by Rabbit Liver Microsomes as Distinct Metabolic Routes. Xenobiotica 5:8, pages 465-474.
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Articles from other publishers (16)

Sebastian Schramm, Nikolai Köhler & Wilfried Rozhon. (2019) Pyrrolizidine Alkaloids: Biosynthesis, Biological Activities and Occurrence in Crop Plants. Molecules 24:3, pages 498.
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Nicholas H Oberlies, Nam-Cheol Kim, Dolores R Brine, Bradley J Collins, Robert W Handy, Charles M Sparacino, Mansukh C Wani & Monroe E Wall. (2007) Analysis of herbal teas made from the leaves of comfrey (Symphytum officinale): reduction of N-oxides results in order of magnitude increases in the measurable concentration of pyrrolizidine alkaloids. Public Health Nutrition 7:7, pages 919-924.
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Peter Hlavica & Michael Lehnerer. (2006) Some aspects of the role of cytochrome P‐450 isozymes in the n‐oxidative transformation of secondary and tertiary amine compounds. Journal of Biochemical Toxicology 10:5, pages 275-285.
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Donna S. Griffin & H.J. Segall. (1989) Effects of the pyrrolizidine alkaloid senecionine and the alkenals trans-4-OH-hexenal and trans-2-hexenal on intracellular calcium compartmentation in isolated hepatocytes. Biochemical Pharmacology 38:3, pages 391-397.
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H.J. Segali, D.W. Wilson, D.S. Griffin, C.K. Winter, C.K. Winter, D.M. Morin & M.W. Lame. 1989. Natural Toxins. Natural Toxins 30 40 .
YIN-TAK WOO, DAVID Y. LAI, JOSEPH C. ARCOS & MARY F. ARGUS. 1988. Natural, Metal, Fiber, and Macromolecular Carcinogens. Natural, Metal, Fiber, and Macromolecular Carcinogens 3 616 .
Donna S. Griffin & H. J. Segall. (1987) Lipid peroxidation and cellular damage caused by the pyrrolizidine alkaloid senecionine, the alkenal trans-4-hydroxy-2-hexenal, and related alkenals. Cell Biology and Toxicology 3:4, pages 379-390.
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Donna S. Griffin & H. J. Segall. (1987) Role of cellular calcium homeostasis in toxic liver injury induced by the pyrrolizidine alkaloid senecionine and the alkenaltrans-4-OH-2-hexenal. Journal of Biochemical Toxicology 2:3, pages 155-167.
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D.S. Griffin & H.J. Segall. (1986) Genotoxicity and cytotoxicity of selected pyrrolizidine alkaloids, A possible alkenal metabolite of the alkaloids, and related alkenals. Toxicology and Applied Pharmacology 86:2, pages 227-234.
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H. J. Segall, D. W. Wilson, J. L. Dallas & William F. Haddon. (1985) Trans -4-Hydroxy-2-Hexenal: a Reactive Metabolite from the Macrocyclic Pyrrolizidine Alkaloid Senecionine . Science 229:4712, pages 472-475.
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Matthew Suffness & Geoffrey A. Cordell. 1985. 1 355 .
A.R. Mattocks & I. Bird. (1983) Pyrrolic and N-oxide metabolites formed from pyrrolizidine alkaloids by hepatic microsomes in vitro: Relevance to in vivo hepatotoxicity. Chemico-Biological Interactions 43:2, pages 209-222.
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H.L. Holland. 1981. 323 400 .
Peter Hlavica & Maria Kehl. 1977. Microsomes and Drug Oxidations. Microsomes and Drug Oxidations 346 353 .
Paul M. Newberne, Wing-Cheung Michael Chan & Adrianne E. Rogers. (1974) Influence of light, riboflavin, and carotene on the response of rats to the acute toxicity of aflatoxin and monocrotaline. Toxicology and Applied Pharmacology 28:2, pages 200-208.
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Charles F. Chesney & James R. Allen. (1973) Resistance of the guinea pig to pyrrolizidine alkaloid intoxication. Toxicology and Applied Pharmacology 26:3, pages 385-392.
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