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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 2
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Research Article

The Role of the Gut Flora in the Metabolism of Prontosil and Neoprontosil in the Rat

R. Gingell Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2, UK
,
J. W. Bridges Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2, UK
&
R. T. Williams Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2, UK
Pages 143-156 | Received 26 May 1971, Published online: 15 Sep 2008

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Dong-Hyun Kim. (2023) Interaction of drugs with gut microbiota modulators. Drug Metabolism Reviews 55:3, pages 181-194.
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Emma L. McConnell, Fang Liu & Abdul W. Basit. (2009) Colonic treatments and targets: issues and opportunities. Journal of Drug Targeting 17:5, pages 335-363.
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R. E. Williams, H. W. Eyton-Jones, M. J. Farnworth, R. Gallagher & W. M. Provan. (2002) Effect of intestinal microflora on the urinary metabolic profile of rats: a 1 H-nuclear magnetic resonance spectroscopy study. Xenobiotica 32:9, pages 783-794.
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O. Ueda, S. Kitamura, R. Kubo, Y. Yano, Y. Kanzaki, T. Fujimoto, K. Tatsumi & S. Ohta. (2001) Metabolism of 2-nitrofluorene, 2-aminofluorene and 2-acylaminofluorenes in rat and dog and the role of intestinal bacteria. Xenobiotica 31:1, pages 33-49.
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S. Kitamura, M. Mita, K. Matsuda, S. Ohta & K. Tatsumi. (2000) Reduction of stilbene oxide and styrene oxide to the corresponding alkenes by intestinal bacteria. Xenobiotica 30:4, pages 359-369.
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Takehiro Yamaguchi, Kenji Sasaki, Yuji Kurosaki, Taiji Nakayama & Toshikiro Kimura. (1994) Biopharmaceutical Evaluation of Salicylazosulfanilic Acid as a Novel Colon-Targeted Prodrug of 5-Aminosalicylic Acid. Journal of Drug Targeting 2:2, pages 123-131.
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G. Groenewoud & H. K. L. Hundt. (1984) The microbial metabolism of (+)-catechin to two novel diarylpropan-2-ol metabolites in vitro. Xenobiotica 14:9, pages 711-717.
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W. Robert Jondorf. (1981) Drug-metabolizing Enzymes as Evolutionary Probes. Drug Metabolism Reviews 12:2, pages 379-430.
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E. J. A. Kuzniar & S. P. James. (1981) Influence of the gut microflora on the metabolism of 4-nitrobenzoic acid in the marmoset. Xenobiotica 11:10, pages 675-683.
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H. P. A. Illing. (1981) Techniques for microfloral and associated metabolic studies in relation to the absorption and enterohepatic circulation of drugs. Xenobiotica 11:12, pages 815-830.
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V. Facchini & L. A. Griffiths. (1980) Metabolism of nitromide in the rat. II. Sites of nitro-reduction. Xenobiotica 10:4, pages 299-305.
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D. M. Gardner & A. G. Renwick. (1978) The Reduction of Nitrobenzoic Acids in the Rat. Xenobiotica 8:11, pages 679-690.
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R. Jonen-kern, H. G. Jonen, R. R. Schupp, K. Minck, G. F. Kahl & K. J. Netter. (1978) Reductive Drug Metabolism in Isolated Perfused Rat Liver under Restricted Oxygen Supply. Xenobiotica 8:5, pages 271-280.
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Ralph Gingell & J. W. Bridges. (1973) Intestinal Azo-reduction and Glucuronide Conjugation of Prontosil. Xenobiotica 3:9, pages 599-604.
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Hasse Schröder & Bengt E. Gustafsson. (1973) Azo Reduction of Salicyl-Azo-Sulphapyridine in Germ-free and Conventional Rats. Xenobiotica 3:4, pages 225-231.
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