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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 2
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Research Article

The Metabolism of Thiophen in the Rabbit and the Rat

H. G. Bray Department of Biochemistry, University of Birmingham, Birmingham, B15 2TT, UK
,
F. M. B. Carpanini Department of Biochemistry, University of Birmingham, Birmingham, B15 2TT, UK
&
B. D. Waters Department of Biochemistry, University of Birmingham, Birmingham, B15 2TT, UK
Pages 157-168 | Received 12 May 1971, Published online: 15 Sep 2008

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AminA. Nomeir, PeterM. Markham & Marjory Chadwick. (1993) Pulmonary absorption and disposition of [14C]thiophene in rats following nose‐only inhalation exposure. Journal of Toxicology and Environmental Health 39:2, pages 223-236.
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R. J. S. Hickman, B. J. Christie, R. W. Guy & T. J. White. (1992) Thioethers as urinary metabolites of thiophene and monobromothiophenes. Xenobiotica 22:8, pages 917-923.
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M. J. Lynch, F. R. Mosher, W. R. Levesque & T. J. Newby. (1987) The in Vitro and in Vivo Metabolism of Morantel in Cattle and Toxicology Species. Drug Metabolism Reviews 18:2-3, pages 253-288.
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L. F. Chasseaud. (1974) The Nature and Distribution of Enzymes Catalyzing the Conjugation of Glutathione with Foreign Compounds. Drug Metabolism Reviews 2:1, pages 185-220.
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Articles from other publishers (27)

R. Bevan, P.T.C. Harrison, B. Jeffery & D. Mitchell. (2020) Evaluating the risk to humans from mineral oils in foods: Current state of the evidence. Food and Chemical Toxicology 136, pages 110966.
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Samuel M. Cohen, Shoji Fukushima, Nigel J. Gooderham, F. Peter Guengerich, Stephen S. Hecht, Ivonne M.C.M. Rietjens, Robert L. Smith, Maria Bastaki, Christie L. Harman, Margaret M. McGowen, Luis G. Valerio & Sean V. Taylor. (2017) Safety evaluation of substituted thiophenes used as flavoring ingredients. Food and Chemical Toxicology 99, pages 40-59.
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. (2015) Scientific Opinion on Flavouring Group Evaluation 21, Revision 5 (FGE.21Rev5): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30. EFSA Journal 13:4.
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Darja Gramec, Lucija Peterlin Mašič & Marija Sollner Dolenc. (2014) Bioactivation Potential of Thiophene-Containing Drugs. Chemical Research in Toxicology 27:8, pages 1344-1358.
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. (2013) Scientific Opinion on Flavouring Group Evaluation 21, Revision 4 (FGE.21Rev4): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30. EFSA Journal 11:11.
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. (2012) Scientific Opinion on Mineral Oil Hydrocarbons in Food. EFSA Journal 10:6.
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Peter M. Rademacher, Caleb M. Woods, Qingbiao Huang, Grazyna D. Szklarz & Sidney D. Nelson. (2012) Differential Oxidation of Two Thiophene-Containing Regioisomers to Reactive Metabolites by Cytochrome P450 2C9. Chemical Research in Toxicology 25:4, pages 895-903.
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. (2012) Scientific Opinion on Flavouring Group Evaluation 21, Revision 3 (FGE.21Rev3): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30. EFSA Journal 10:2, pages 2457.
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Alexander V. LyubimovDeepak K. Dalvie & Cho‐Ming Loi. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 36 .
Alexander V. LyubimovDeepak K. Dalvie. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 54 .
. (2011) Scientific Opinion on Flavouring Group Evaluation 21, Revision 2 (FGE.21Rev2): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. EFSA Journal 9:10, pages 1989.
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Matthew Badland, Delphine Compère, Karine Courté, Anne-Claude Dublanchet, Stéphane Blais, Ajith Manage, Guillaume Peron & Roger Wrigglesworth. (2011) Thiophene and bioisostere derivatives as new MMP12 inhibitors. Bioorganic & Medicinal Chemistry Letters 21:1, pages 528-530.
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Graham F. Smith. 2011. Progress in Medicinal Chemistry Volume 50. Progress in Medicinal Chemistry Volume 50 1 47 .
. (2009) Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30. EFSA Journal 7:8.
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. (2008) Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) ‐ Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC). EFSA Journal 6:3.
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Anne Dreiem & Frode Fonnum. (2004) Thiophene is Toxic to Cerebellar Granule Cells in Culture After Bioactivation by Rat Liver Enzymes. NeuroToxicology 25:6, pages 959-966.
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F. Fonnum & E. A. Lock. (2003) The contributions of excitotoxicity, glutathione depletion and DNA repair in chemically induced injury to neurones: exemplified with toxic effects on cerebellar granule cells. Journal of Neurochemistry 88:3, pages 513-531.
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Daniel Mansuy & Patrick M. Dansette. 1996. Biological Reactive Intermediates V. Biological Reactive Intermediates V 1 6 .
P.M. Dansette, Do Cao Thang & H. El Amri D. Mansuy. (1992) Evidence for thiophene-s-oxide as a primary reactive metabolite of thiophene in vivo: Formation of a dihydrothiophene sulfoxide mercapturic acid. Biochemical and Biophysical Research Communications 186:3, pages 1624-1630.
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P.M. Dansette, C. Amar, P. Valadon, C. Pons, P.H. Beaune & D. Mansuy. (1991) Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes. Biochemical Pharmacology 41:4, pages 553-560.
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E. Neau, P.M. Dansette, V. Andronik & D. Mansuy. (1990) Hydroxylation of the thiophene ring by hepatic monooxygenases. Biochemical Pharmacology 39:6, pages 1101-1107.
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P.M. Dansette, C. Amar, C. Smith, C. Pons & D. Mansuy. (1990) Oxidative activation of the thiophene ring by hepatic enzymes. Biochemical Pharmacology 39:5, pages 911-918.
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Daniel Mansuy, Patrick M. Dansette, Christine Foures, Maryse Jaouen, G?rard Moinet & No?l Bayer. (1984) Metabolic hydroxylation of the thiophene ring: Isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and rat. Biochemical Pharmacology 33:9, pages 1429-1435.
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. 1984. Comprehensive Heterocyclic Chemistry. Comprehensive Heterocyclic Chemistry 673 731 .
L.A. Damani & D.E. Case. 1984. Comprehensive Heterocyclic Chemistry. Comprehensive Heterocyclic Chemistry 223 246 .
L.A. DAMANI & P.A. CROOKS. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 69 89 .
L.F. Chasseaud. 1979. 175 274 .

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