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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 6
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Research Article

The Metabolic Fate of [Vinyl-I-14C]Dichlorvos in the Rat after Oral and Inhalation Exposure

D. H. Hutson Shell Research Ltd., Tunstall Laboratory, Sittingbourne Laboratories, Sittingbourne, Kent
,
Elizabeth C. Hoadley Shell Research Ltd., Tunstall Laboratory, Sittingbourne Laboratories, Sittingbourne, Kent
&
B. A. Pickering Shell Research Ltd., Tunstall Laboratory, Sittingbourne Laboratories, Sittingbourne, Kent
Pages 593-611 | Received 30 Sep 1971, Published online: 14 Oct 2008

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Renu Gandhi & SuzanneM. Snedeker. (2002) Critical Evaluation of Dichlorvos’ Breast Cancer Risk. Comments on Toxicology 8:1, pages 85-123.
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I. J. G. Climie, D. H. Hutson & G. Stoydin. (1983) The metabolism of ethylbenzene hydroperoxide in the rat. Xenobiotica 13:10, pages 611-618.
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Melvin Dwaine Reuber. (1981) Carcinogenicity of Dichlorvos. Clinical Toxicology 18:1, pages 47-84.
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Maureen J. Crawford, D. H. Hutson & G. Stoydin. (1980) The metabolic fate of a herbicidal methylmercapto-s-triazine (cyanatryn) in the rat. Xenobiotica 10:3, pages 169-185.
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JamesR. Gillette & LanceR. Pohl. (1977) A prospective on covalent binding and toxicity. Journal of Toxicology and Environmental Health 2:4, pages 849-871.
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W. Dedek. (1975) Radioaktive Nuklide in der Pestizid-Forschung. Isotopenpraxis Isotopes in Environmental and Health Studies 11:11, pages 378-385.
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John S. Leary, William T. Keane, Cleve Fontenot, Edmund F. Feichtmeir, David Schultz, Bela A. Koos, Louis Hirsch, Edward M. Lavor, Clifford C. Roan & Charles H. Hine. (1974) Safety Evaluation in the Home of Polyvinyl Chloride Resin Strip Containing Dichlorvos (DDVP). Archives of Environmental Health: An International Journal 29:6, pages 308-314.
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C. T. Bedford & J. Robinson. (1972) The Alkylating Properties of Organophosphates. Xenobiotica 2:4, pages 307-337.
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D. H. Hutson & Elizabeth C. Hoadley. (1972) The Metabolism of [14C-Methyl]Dichlorvos in the Rat and the Mouse. Xenobiotica 2:2, pages 107-116.
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Jindan Yang, Xiaowei Sun, Zhijing Feng, Dongfang Hao, Maoqing Wang, Xiujuan Zhao & Changhao Sun. (2011) Metabolomic analysis of the toxic effects of chronic exposure to low-level dichlorvos on rats using ultra-performance liquid chromatography–mass spectrometry. Toxicology Letters 206:3, pages 306-313.
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Ismail Celik, Zeycan Yilmaz & Vedat Turkoglu. (2008) Hematotoxic and hepatotoxic effects of dichlorvos at sublethal dosages in rats. Environmental Toxicology 24:2, pages 128-132.
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I. Morozov, S. Gligorovski, P. Barzaghi, D. Hoffmann, Y. G. Lazarou, E. Vasiliev & H. Herrmann. (2008) Hydroxyl radical reactions with halogenated ethanols in aqueous solution: Kinetics and thermochemistry. International Journal of Chemical Kinetics 40:4, pages 174-188.
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Ewan D. Booth, Eryl Jones & Barry M. Elliott. (2007) Review of the in vitro and in vivo genotoxicity of dichlorvos. Regulatory Toxicology and Pharmacology 49:3, pages 316-326.
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. (2006) Opinion of the Scientific Panel on Plant protection products and their residues (PPR) related to the evaluation of dichlorvos in the context of Council Directive 91/414/EEC. EFSA Journal 4:4.
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Jan E. Storm. 2003. Patty's Toxicology. Patty's Toxicology.
Po C. Chan, James Huff, Joseph K. Haseman, Roger Alison & J. D. Prejean. (2005) Carcinogenesis Studies of Dichlorvos in Fischer Rats and B6C3F1 Mice. Japanese Journal of Cancer Research 82:2, pages 157-164.
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J.N. Bremmer, A.I.T. Walker & P. Grasso. (1988) Is dichlorvos a carcinogenic risk for humans?. Mutation Research Letters 209:1-2, pages 39-44.
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G.D. PAULSON. 1986. Principles, Statistics, and Applications. Principles, Statistics, and Applications 201 229 .
Paul W. Ferguson, Sarah A. Jewell, Robert I. Krieger & Otto G. Raabe. (2009) Carbofuran disposition in the rat after aerosol inhalation. Environmental Toxicology and Chemistry 1:3, pages 245-258.
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R. Braun, J. Sch?neich, L. Weissflog & W. Dedek. (1982) Activity of organophosphorus insecticides in bacterial tests for mutagenicity and DNA repair ? Direct alkylation vs. metabolic activation and breakdown. I. Butonate, vinylbutonate, trichlorfon, dichlorvos, demethyl dichlorvos and demethyl vinylbutonate. Chemico-Biological Interactions 39:3, pages 339-350.
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JOSEPH C. ARCOS, YIN-TAK WOO & MARY F. ARGUS. 1982. Aliphatic Carcinogens. Aliphatic Carcinogens 1 681 .
. 1982. Metabolic Maps of Pesticides. Metabolic Maps of Pesticides 212 219 .
Dan Segerbäck & Lars Ehrenberg. (2009) Alkylating Properties of Dichlorvos (DDVP). Acta Pharmacologica et Toxicologica 49, pages 56-66.
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A.A. Nomeir, S. Kato & H.B. Matthews. (1981) The metabolism and disposition of tris(1,3-dichloro-2-propyl) phosphate (fyrol FR-2) in the rat. Toxicology and Applied Pharmacology 57:3, pages 401-413.
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C. Ramel, J. Drake & T. Sugimura. (1980) An evaluation of the genetic toxicity of dichlorvos. Mutation Research/Reviews in Genetic Toxicology 76:3, pages 297-309.
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E. Reiner, V. Simeon & M. Škrinjarić-Špoljar. (1980) Hydrolysis of O,O-dimethyl-2,2-dichlorovinyl phosphate (DDVP) by esterases in parasitic heliminths, and in vertebrate plasma and erythrocytes. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 66:2, pages 149-152.
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Arun P. Kulkarni & Ernest Hodgson. (1980) Metabolism of insecticides by mixed function oxidase systems. Pharmacology & Therapeutics 8:2, pages 379-475.
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Lance R. Pohl, Guruva B. Reddy & Gopal Krishna. (1979) A new pathway of metabolism of chloramphenicol which influences the interpretation of its irreversible binding to protein in vivo. Biochemical Pharmacology 28:16, pages 2433-2440.
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H.B. Matthews. (1979) Excretion of insecticides. Pharmacology & Therapeutics 4:3, pages 657-675.
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G. Schmidt, M. Schmidt, M. Nenner & F. Vetterlein. (1978) Effects of dichlorvos (DDVP) inhalation on the activity of acetylcholinesterase in the bronchial tissue of rats. Archives of Toxicology 42:3, pages 191-198.
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A. S. Wright, D. H. Hutson & M. F. Wooder. (1978) The chemical and biochemical reactivity of dichlorvos. Archives of Toxicology 42:1, pages 1-18.
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Bo Holmstedt, Ingrid Nordgren, Marianne Sandoz & Anders Sundwall. (1978) Metrifonate. Archives of Toxicology 41:1, pages 3-29.
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D. J. Ecobichon. 2011. Comprehensive Physiology. Comprehensive Physiology 441 454 .
M.F. Wooder, A.S. Wright & L.J. King. (1977) In vivo alkylation studies with dichlorvos at practical use concentrations. Chemico-Biological Interactions 19:1, pages 25-46.
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Marion Ehrich & Steven D. Cohen. (1977) Effect of dichlorvos (DDVP) on mouse liver glutathione levels and lack of potentiation by methyl iodide and TOTP. Biochemical Pharmacology 26:10, pages 997-1000.
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Morton Civen, Eric Lifrak & Charlesta B. Brown. (1977) Studies on the mechanism of inhibition of adrenal steroidogenesis by organophosphate and carbamate compounds. Pesticide Biochemistry and Physiology 7:2, pages 169-182.
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G.D. Paulson. 1977. Fate of Pesticides in Large Animals. Fate of Pesticides in Large Animals 17 45 .
Steven D. Cohen & Marion Ehrich. (1976) Cholinesterase and carboxylesterase inhibition by dichlorvos and interactions with malathion and triorthotolyl phosphate. Toxicology and Applied Pharmacology 37:1, pages 39-48.
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W. Dedek, Kh. Lohs, G.W. Fischer & R. Schmidt. (1976) Alkylation of guanine in mice in vivo by organophosphorus insecticides. I. Trichlorphone and butonate. Pesticide Biochemistry and Physiology 6:2, pages 101-110.
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D. Blair, Elizabeth C. Hoadley & D.H. Hutson. (1975) The distribution of dichlorvos in the tissues of mammals after its inhalation or intravenous administration. Toxicology and Applied Pharmacology 31:2, pages 243-253.
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DIETER WILD. (1975) Mutagenicity studies on organophosphorus insecticides. Mutation Research/Reviews in Genetic Toxicology 32:2, pages 133-149.
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Ph. Gerolt. (1974) Mechanism of resistance to dichlorvos in adult houseflies. Pesticide Biochemistry and Physiology 4:3, pages 275-288.
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B. J. Dean, S. M. A. Doak & J. Funnell. (1972) Genetic studies with dichlorvos in the host-mediated assay and in liquid medium usingSaccharomyces Cerevisiae. Archiv f�r Toxikologie 30:1, pages 61-66.
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D. H. Hutson & E. C. Hoadley. (1972) The comparative metabolism of [14C-vinyl]dichlorvos in animals and man. Archiv f�r Toxikologie 30:1, pages 9-18.
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