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Xenobiotica
the fate of foreign compounds in biological systems
Volume 2, 1972 - Issue 1
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Research Article

Dealkylation and N-Oxidation in the Metabolism of I-Diethylcarbamyl-4-Methylpiperazine in the Rat

J. K. Faulkner Research Division, The Pfizer Group, Sandwich, Kent, UK
&
K. J. A. Smith Research Division, The Pfizer Group, Sandwich, Kent, UK
Pages 59-68 | Received 12 Oct 1971, Published online: 22 Sep 2008

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Peter Hlavica & John W. Gorrod. (1982) Biological Oxidation of Nitrogen in Organic Compounds and Disposition of N-Oxidized Product. Critical Reviews in Biochemistry 12:1, pages 39-101.
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G. Edwards, S. A. Ward, A. M. Breckenridge & M. L'e Orme. (1981) Identification and quantification of diethylcarbamazine and diethylcarbamazine N-oxide in rat urine. Xenobiotica 11:4, pages 281-284.
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Articles from other publishers (15)

Trilok Chandra Goel & Apul GoelTrilok Chandra Goel & Apul Goel. 2016. Lymphatic Filariasis. Lymphatic Filariasis 95 110 .
C A Joseph & P A F Dixon. (1984) A possible cytochrome P-450-mediated N -oxidation of diethylcarbamazine . Journal of Pharmacy and Pharmacology 36:10, pages 711-712.
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Orish E. Orisakwe, Ndidi A. Ilondu, O.Johnson Afonne, Sabinus I. Ofoefule & Chinna N. Orish. (2000) Acceleration of Body Clearance of DiethylCarbamazine By Oral Activated Charcoal. Pharmacological Research 42:2, pages 167-170.
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Sukhyang Lee, Dee Ann Casteel & Lawrence Fleckenstein. (1997) Specific gas chromatographic analysis of diethylcarbamazine in human plasma using solid-phase extraction. Journal of Chromatography B: Biomedical Sciences and Applications 704:1-2, pages 181-185.
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Sukhyang Lee. (1996) Analysis of diethylcarbamazine and diethylcarbamazine-N-oxide by gas chromatography. Archives of Pharmacal Research 19:6.
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Jerzy W. Jaroszewski, Dina Berenstein, Frank A. Sløk, Paul Erik Simonsen & Mette K. Agger. (1996) Determination of diethylcarbamazine, an antifilarial drug, in human urine by 1H-NMR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis 14:5, pages 543-549.
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J. Elks & C. R. Ganellin. 1990. Dictionary of Drugs. Dictionary of Drugs 344 475 .
F. Kani, M. -C. Dessalles, C. Jacquot, G. Mahuzier & P. Gayral. (1986) Filariose expérimentale duProechimys oris parDipetalonema dessetae: 5. Effet du parasitisme sur le métabolisme de la diéthylcarbamazine. European Journal of Drug Metabolism and Pharmacokinetics 11:3, pages 211-223.
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D. J. Weiner, D. Abraham & R. D'Antonio. (1986) The effect of diethylcarbamazine on microfilariae ofLitomosoides carinii in vitro and in vivo. Zeitschrift f�r Parasitenkunde Parasitology Research 72:6, pages 805-813.
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M.D. Coleman, G. Edwards, G.W. Mihaly, R.E. Howells & A.M. Breckenridge. (1984) High-performance liquid chromatographic method for the determination of pyrimethamine and its 3-N-oxide metabolite in biological fluids. Journal of Chromatography B: Biomedical Sciences and Applications 308, pages 363-369.
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Félicien Kani, Philippe Gayral, Marie-Christine Pfaff-Dessales, Georges Mahuzier, Christian Jacquot & Jean-Louis Auget. (1983) Experimental filariasis ofDipetalonema dessetae inProechimys oris: 3. Effects of parasitism on the pharmacokinetics of diethylcarbamazine. European Journal of Drug Metabolism and Pharmacokinetics 8:4, pages 313-320.
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KK Adjepon‐Yamoah, G Edwards, AM Breckenridge, ML Orme & SA Ward. (2012) The effect of renal disease on the pharmacokinetics of diethylcarbamazine in man.. British Journal of Clinical Pharmacology 13:6, pages 829-834.
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Frank Hawking. 1979. 129 194 .
Neal CastagnoliJr.Jr.. 1978. Stimulants. Stimulants 335 387 .
J. J. P. Heykants, W. E. G. Meuldermans, A. G. Knaeps & L. J. M. Michiels. (1977) The excretion and netabolism of the antidiarrhoeal loperamide in the Wistar rat. European Journal of Drug Metabolism and Pharmacokinetics 2:2, pages 81-91.
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