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Xenobiotica
the fate of foreign compounds in biological systems
Volume 2, 1972 - Issue 2
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Research Article

The Metabolism of [14C-Methyl]Dichlorvos in the Rat and the Mouse

D. H. Hutson Shell Research Limited, Tunstall Laboratory, Sittingbourne, Kent, England
&
Elizabeth C. Hoadley Shell Research Limited, Tunstall Laboratory, Sittingbourne, Kent, England
Pages 107-116 | Received 30 Dec 1971, Published online: 22 Sep 2008

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Renu Gandhi & SuzanneM. Snedeker. (2002) Critical Evaluation of Dichlorvos’ Breast Cancer Risk. Comments on Toxicology 8:1, pages 85-123.
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GeorgeA. Maw. (1982) Biochemistry of S-Methyl-L-Cysteine and its Principal Derivatives. Sulfur reports 2:1, pages 1-26.
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John S. Leary, William T. Keane, Cleve Fontenot, Edmund F. Feichtmeir, David Schultz, Bela A. Koos, Louis Hirsch, Edward M. Lavor, Clifford C. Roan & Charles H. Hine. (1974) Safety Evaluation in the Home of Polyvinyl Chloride Resin Strip Containing Dichlorvos (DDVP). Archives of Environmental Health: An International Journal 29:6, pages 308-314.
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L. F. Chasseaud. (1974) The Nature and Distribution of Enzymes Catalyzing the Conjugation of Glutathione with Foreign Compounds. Drug Metabolism Reviews 2:1, pages 185-220.
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Articles from other publishers (34)

Kandasamy Saravanakumar, SeonJu Park, Sampathkumar Vijayasarathy, Akila Swaminathan, Sugavaneswaran Sivasantosh, Yebon Kim, Guijae Yoo, Hariharamohan Madhumitha, Davoodbasha MubarakAli & Namki Cho. (2024) Cellular metabolism and health impacts of dichlorvos: Occurrence, detection, prevention, and remedial strategies-A review. Environmental Research 242, pages 117600.
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Huixin Wang, Michael G. Leeming, Blake J. Cochran, James M. Hook, Junming Ho, Giang T. H. Nguyen, Ling Zhong, Claudiu T. Supuran & William A. Donald. (2020) Nontargeted Identification of Plasma Proteins O-, N-, and S-Transmethylated by O-Methyl Organophosphates. Analytical Chemistry 92:23, pages 15420-15428.
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Henshaw Uchechi Okoroiwu & Iwara Arikpo Iwara. (2018) Dichlorvos toxicity: A public health perspective. Interdisciplinary Toxicology 11:2, pages 129-137.
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Tri M. Bui-Nguyen, Christine E. Baer, John A. Lewis, Dongren Yang, Pamela J. Lein & David A. Jackson. (2015) Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio. BMC Genomics 16:1.
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Tri M. Bui-Nguyen, William E. Dennis, David A. Jackson, Jonathan D. Stallings & John A. Lewis. (2014) Detection of Dichlorvos Adducts in a Hepatocyte Cell Line. Journal of Proteome Research 13:8, pages 3583-3595.
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A. Eben. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 6 .
Jindan Yang, Xiaowei Sun, Zhijing Feng, Dongfang Hao, Maoqing Wang, Xiujuan Zhao & Changhao Sun. (2011) Metabolomic analysis of the toxic effects of chronic exposure to low-level dichlorvos on rats using ultra-performance liquid chromatography–mass spectrometry. Toxicology Letters 206:3, pages 306-313.
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Ismail Celik, Zeycan Yilmaz & Vedat Turkoglu. (2008) Hematotoxic and hepatotoxic effects of dichlorvos at sublethal dosages in rats. Environmental Toxicology 24:2, pages 128-132.
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Ewan D. Booth, Eryl Jones & Barry M. Elliott. (2007) Review of the in vitro and in vivo genotoxicity of dichlorvos. Regulatory Toxicology and Pharmacology 49:3, pages 316-326.
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Jan E. Storm. 2003. Patty's Toxicology. Patty's Toxicology.
Ch.E. Kientz, A. Verweij, G.J. de Jong & U.A. Th. Brinkman. (1992) Flame-based thermionic detection coupled on-line with microcolumn liquid chromatography. Journal of Chromatography A 626:1, pages 59-69.
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JOSEPH C. ARCOS, YIN-TAK WOO & MARY F. ARGUS. 1982. Aliphatic Carcinogens. Aliphatic Carcinogens 1 681 .
. 1982. Metabolic Maps of Pesticides. Metabolic Maps of Pesticides 212 219 .
C. Ramel, J. Drake & T. Sugimura. (1980) An evaluation of the genetic toxicity of dichlorvos. Mutation Research/Reviews in Genetic Toxicology 76:3, pages 297-309.
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E. Reiner, V. Simeon & M. Škrinjarić-Špoljar. (1980) Hydrolysis of O,O-dimethyl-2,2-dichlorovinyl phosphate (DDVP) by esterases in parasitic heliminths, and in vertebrate plasma and erythrocytes. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 66:2, pages 149-152.
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L.F. Chasseaud. 1979. 175 274 .
G. Schmidt, M. Schmidt, M. Nenner & F. Vetterlein. (1978) Effects of dichlorvos (DDVP) inhalation on the activity of acetylcholinesterase in the bronchial tissue of rats. Archives of Toxicology 42:3, pages 191-198.
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A. S. Wright, D. H. Hutson & M. F. Wooder. (1978) The chemical and biochemical reactivity of dichlorvos. Archives of Toxicology 42:1, pages 1-18.
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Bo Holmstedt, Ingrid Nordgren, Marianne Sandoz & Anders Sundwall. (1978) Metrifonate. Archives of Toxicology 41:1, pages 3-29.
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D. J. Ecobichon. 2011. Comprehensive Physiology. Comprehensive Physiology 441 454 .
M.F. Wooder, A.S. Wright & L.J. King. (1977) In vivo alkylation studies with dichlorvos at practical use concentrations. Chemico-Biological Interactions 19:1, pages 25-46.
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Marion Ehrich & Steven D. Cohen. (1977) Effect of dichlorvos (DDVP) on mouse liver glutathione levels and lack of potentiation by methyl iodide and TOTP. Biochemical Pharmacology 26:10, pages 997-1000.
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D. H. HUTSON. 1976. Bound and Conjugated Pesticide Residues. Bound and Conjugated Pesticide Residues 103 131 .
W. Dedek, Kh. Lohs, G.W. Fischer & R. Schmidt. (1976) Alkylation of guanine in mice in vivo by organophosphorus insecticides. I. Trichlorphone and butonate. Pesticide Biochemistry and Physiology 6:2, pages 101-110.
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Lawrence Fishbein. 1976. Insecticide Biochemistry and Physiology. Insecticide Biochemistry and Physiology 555 603 .
K.V. Shooter. (1975) Assays for phosphotriester formation in the reaction of bacteriophage R17 with a group of alkylating agents. Chemico-Biological Interactions 11:6, pages 575-588.
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D. Blair, Elizabeth C. Hoadley & D.H. Hutson. (1975) The distribution of dichlorvos in the tissues of mammals after its inhalation or intravenous administration. Toxicology and Applied Pharmacology 31:2, pages 243-253.
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DIETER WILD. (1975) Mutagenicity studies on organophosphorus insecticides. Mutation Research/Reviews in Genetic Toxicology 32:2, pages 133-149.
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Ph. Gerolt. (1974) Mechanism of resistance to dichlorvos in adult houseflies. Pesticide Biochemistry and Physiology 4:3, pages 275-288.
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Rune Wennerberg & Göran Löfroth. (1974) Formation of 7-methylguanine by dichlorvos in bacteria and mice. Chemico-Biological Interactions 8:5, pages 339-348.
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P.D. Lawley, S.A. Shah & D.J. Orr. (1974) Methylation of nucleic acids by 2,2-dichlorovinyl dimethyl phosphate (dichlorvos, DDVP). Chemico-Biological Interactions 8:3, pages 171-182.
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B. J. Dean & E. Thorpe. (1972) Cytogenetic studies with dichlorvos in mice and chinese hamsters. Archiv f�r Toxikologie 30:1, pages 39-49.
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A. C. Page, J. E. Loeffler, H. R. Hendrickson, C. K. Huston & D. M. DeVries. (1972) Metabolic fate of dichlorvos in swine. Archiv f�r Toxikologie 30:1, pages 19-27.
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D. H. Hutson & E. C. Hoadley. (1972) The comparative metabolism of [14C-vinyl]dichlorvos in animals and man. Archiv f�r Toxikologie 30:1, pages 9-18.
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