Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 2, 1972 - Issue 2
Submit an article Journal homepage
5
Views
27
CrossRef citations to date
0
Altmetric
Research Article

Bunolol Metabolism by Cell-Free Preparations of Human Liver: Biosynthesis of Dihydrobunolol

Franz-Josef Leinweber Department of Drug Metabolism, Analytical Physical Chemistry, Organic Chemistry and Pharmacology, Warner-Lambert Research Institute, Morris Plains, New Jersey, 07950, USA
,
R. Clive Greenough Department of Drug Metabolism, Analytical Physical Chemistry, Organic Chemistry and Pharmacology, Warner-Lambert Research Institute, Morris Plains, New Jersey, 07950, USA
,
Charles F. Schwender Department of Drug Metabolism, Analytical Physical Chemistry, Organic Chemistry and Pharmacology, Warner-Lambert Research Institute, Morris Plains, New Jersey, 07950, USA
,
Harvey R. Kaplan Department of Drug Metabolism, Analytical Physical Chemistry, Organic Chemistry and Pharmacology, Warner-Lambert Research Institute, Morris Plains, New Jersey, 07950, USA
&
Frederick J. Di Carlo Department of Drug Metabolism, Analytical Physical Chemistry, Organic Chemistry and Pharmacology, Warner-Lambert Research Institute, Morris Plains, New Jersey, 07950, USA
Pages 191-202 | Received 10 Dec 1971, Published online: 22 Sep 2008

Citations (27)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

D.D.-S. Tang-Liu, S. Liu, J. Richman & R. Weinkam. (1986) HPLC Quantitation of Levobunolol and Its Metabolite, Dihydrolevobunolol in Biological Fluids. Journal of Liquid Chromatography 9:10, pages 2237-2252.
Read now
Ronald L. Felsted & Nicholas R. Bachur. (1980) Mammalian Carbonyl Reductases. Drug Metabolism Reviews 11:1, pages 1-60.
Read now
Franz-Josef Leinweber, R. Clive Greenough & Frederick J. Di Carlo. (1976) A New Oxisuran Metabolite. Xenobiotica 6:10, pages 617-624.
Read now

Articles from other publishers (24)

Chwan-Li Shen, Rui Wang, Guangchen Ji, Moamen M. Elmassry, Masoud Zabet-Moghaddam, Heather Vellers, Abdul N. Hamood, Xiaoxia Gong, Parvin Mirzaei, Shengmin Sang & Volker Neugebauer. (2022) Dietary supplementation of gingerols- and shogaols-enriched ginger root extract attenuate pain-associated behaviors while modulating gut microbiota and metabolites in rats with spinal nerve ligation. The Journal of Nutritional Biochemistry 100, pages 108904.
Crossref
U. A. Argikar, J. L. Dumouchel, C. E. Dunne, C. Saran, A. L. Cirello & M. Gunduz. (2016) Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways. Drug Metabolism and Disposition 44:8, pages 1304-1312.
Crossref
N. Srinivas & S. Kaul. (1998) Pharmacokinetics of a nootropic agent, BMY-21502, and its metabolites in beagle dogs. European Journal of Drug Metabolism and Pharmacokinetics 23:1, pages 61-65.
Crossref
Hirotami Ohara, Yoshiyuki Miyabe, Yoshihiro Deyashiki, Kazuya Matsuura & Akira Kara. (1995) Reduction of drug ketones by dihydrodiol dehydrogenases, carbonyl reductase and aldehyde reductase of human liver. Biochemical Pharmacology 50:2, pages 221-227.
Crossref
Dietmar Schomburg & Dörte Stephan. 1995. Enzyme Handbook 10. Enzyme Handbook 10 38 40 .
. 1992. Enzyme Nomenclature. Enzyme Nomenclature 576 727 .
DIANE DAN-SHYA TANG-LIU, MARTHA SHACKLETON & JOSEPH BEN RICHMAN. (1988) Ocular Metabolism of Levobunolol. Journal of Ocular Pharmacology and Therapeutics 4:3, pages 269-278.
Crossref
Diane D-S. Tang-Liu, Sandra Liu, John Neff & Rhonda Sandri. (1987) Disposition of Levobunolol after an Ophthalmic Dose to Rabbits. Journal of Pharmaceutical Sciences 76:10, pages 780-783.
Crossref
Gary D. Novack. (1987) Ophthalmic beta-blockers since timolol. Survey of Ophthalmology 31:5, pages 307-327.
Crossref
CHI CHU CHEN, JANET ANDERSON, MARTHA SHACKLETON & JOHN ATTARD. (1987) The Disposition of Bunolol in the Rabbit Eye. Journal of Ocular Pharmacology and Therapeutics 3:2, pages 149-157.
Crossref
D.F. WOODWARD, G.D. NOVACK, L.S. WILLIAMS, A.L. NIEVES & D.E. POTTER. (1987) Dihydrolevobunolol is a Potent Ocular β-adrenoceptor Antagonist. Journal of Ocular Pharmacology and Therapeutics 3:1, pages 11-15.
Crossref
Heinrich Hengy & Ernst-Ulrich Kölle. (1985) Determination of levobunolol and dihydrolevobunolol in blood and urine by high-performance liquid chromatography using fluorescence detection. Journal of Chromatography B: Biomedical Sciences and Applications 338, pages 444-449.
Crossref
ROBERT E. MCMAHON. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 91 104 .
RONALD L. FELSTED & NICHOLAS R. BACHUR. 1980. Enzymatic Basis of Detoxication. Enzymatic Basis of Detoxication 281 293 .
. 1979. Enzyme Nomenclature 1978. Enzyme Nomenclature 1978 442 524 .
Naked K. Ahmed, Ronald L. Felsted & Nicholas R. Bachur. (1978) Heterogeneity of anthracycline antibiotic carbonyl reductases in mammalian livers. Biochemical Pharmacology 27:23, pages 2713-2719.
Crossref
H.R. Kaplan, M.A. Commarato & E.C. Lattime. (1978) l-Bunolol and Propranolol: Oral and Intravenous β-Adrenoceptor Blocking Activity in Rats Compared to Dogs and Humans. Journal of Pharmaceutical Sciences 67:1, pages 132-133.
Crossref
Franz-Josef Leinweber, Joseph M. Szpiech & Frederick J. Dicarlo. (1978) l-Bunolol Metabolism in Rats: Identification of Urinary Metabolites. Journal of Pharmaceutical Sciences 67:1, pages 129-131.
Crossref
Franz-Josef Leinweber, R. Clive Greenough & Frederick J. Di Carlo. (1977) Bunolol Metabolism by Dogs: Identification of Basic Metabolites and Their Conjugates. Journal of Pharmaceutical Sciences 66:11, pages 1570-1575.
Crossref
Ronald L. Felsted, Donald R. Richter & Nicholas R. Bachur. (1977) Rat liver aldehyde reductase. Biochemical Pharmacology 26:12, pages 1117-1124.
Crossref
Lance R. Pohl, Sidney D. Nelson, William R. Porter, William F. Trager, Michael J. Fasco, Frederick D. Baker & John W. FentonIIII. (1976) Warfarin—stereochemical aspects of its metabolism by rat liver microsomes. Biochemical Pharmacology 25:19, pages 2153-2162.
Crossref
Nicholas R. Bachur. (1976) Cytoplasmic Aldo-Keto Reductases: A Class of Drug Metabolizing Enzymes. Science 193:4253, pages 595-597.
Crossref
. (1976) Enzyme nomenclature: Recommendations (1972) of the International Union of Pure and Applied Chemistry and the International Union of Biochemistry. Biochimica et Biophysica Acta (BBA) - Enzymology 429:1, pages 1-45.
Crossref
W. E. G. Meuldermans, R. M. A. Hurkmans, W. F. J. Lauwers & J. J. P. Heykants. (1976) Thein vitro metabolism of mebendazole by pig, rat and dog liver fractions. European Journal of Drug Metabolism and Pharmacokinetics 1:1, pages 35-40.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.