Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 2, 1972 - Issue 3
Submit an article Journal homepage
29
Views
37
CrossRef citations to date
0
Altmetric
Research Article

Mechanisms of Mammalian Hydroxylation: Some Novel Metabolites of Chlorobenzene

J. R. Lindsay Smith Department of Chemistry, University of York, York, YO1 5DD, England
,
B. A. J. Shaw Imperial Chemical Industries Limited, Pharmaceuticals Division, Research Department, Alderley Park, Macclesfield, Cheshire, England
&
D. M. Foulkes Department of Chemistry, University of York, York, YO1 5DD, England
Pages 215-226 | Received 10 Mar 1972, Published online: 22 Sep 2008

Citations (37)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

. (1990) Notice of Intended Change—Chlorobenzene. Applied Occupational and Environmental Hygiene 5:9, pages 640-642.
Read now
W. M. Kluwe, G. Dill, R. Persing & A. Peters. (1985) Toxic responses to acute, subchron1c, and chronic oral administrations of monochlorobenzene to rodents. Journal of Toxicology and Environmental Health 15:6, pages 745-767.
Read now
P. G. C. Douch & L. L. Buchanan. (1978) Glutathione Conjugation of some Xenobiotics by Ascaris suum and Moniezia expansa. Xenobiotica 8:3, pages 171-176.
Read now
L. F. Chasseaud. (1974) The Nature and Distribution of Enzymes Catalyzing the Conjugation of Glutathione with Foreign Compounds. Drug Metabolism Reviews 2:1, pages 185-220.
Read now
Hans-Günter Neumann & Jürgen Schenk. (1973) Radio Gas Chromatography of Drug Metabolites in Tissue Extracts. Xenobiotica 3:7, pages 435-450.
Read now

Articles from other publishers (32)

A. Philip Leber & James S. Bus. 2003. Patty's Toxicology. Patty's Toxicology 323 358 .
J. Lewalter & P. Biedermann. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 21 .
J. Lewalter. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 38 44 .
J. Lewalter. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 10 .
A. Philip Leber Ph.D & James S. Bus. 2003. Patty's Toxicology. Patty's Toxicology.
Ivonne M. C. M. Rietjens, Ans E. M. F. Soffers, Cees Veeger & Jacques Vervoort. (2002) Regioselectivity of cytochrome P-450 catalyzed hydroxylation of fluorobenzenes predicted by calculated frontier orbital substrate characteristics. Biochemistry 32:18, pages 4801-4812.
Crossref
Masana Ogata, Toyohiro Taguchi, Naomasa Hirota, Yoshihiro Shimada & Seitaro Nakae. (1991) Quantitation of urinary chlorobenzene metabolites by HPLC: concentrations of 4-chlorocatechol and chlorophenols in urine and of chlorobenzene in biological specimens of subjects exposed to chlorobenzene. International Archives of Occupational and Environmental Health 63:2, pages 121-128.
Crossref
Toshiaki Yoshida, Katashi Andoh & Takeo Tabuchi. (1991) Identification of urinary metabolites in rats treated withp-chloronitrobenzene. Archives of Toxicology 65:1, pages 52-58.
Crossref
C. C. Willhite & S. A. Book. (1990) Toxicology update. Journal of Applied Toxicology 10:4, pages 307-310.
Crossref
E. Krewet, G. Müller & K. Norpoth. (1989) The excretion of chlorophenylmercapturic acid, chlorophenols and a guanine adduct in the urine of chlorobenzene-treated rats after phenobarbital pretreatment. Toxicology 59:1, pages 67-79.
Crossref
G. Truchon, J. Brodeur & M. Gérin. (2006) Specific determination of bromobenzene metabolites by high‐performance liquid chromatography. Journal of Applied Toxicology 9:2, pages 123-127.
Crossref
E.C. Horning, K. Lertratanangkoon & M.G. Horning. (1987) Metabolism of bromobenzene. Journal of Chromatography A 399, pages 321-339.
Crossref
Eva Brittebo & Ingvar Brandt. (1984) Metabolism of chlorobenzene in the mucosa of the murine respiratory tract. Lung 162:1, pages 79-88.
Crossref
R.W. Chadwick, T.M. Scotti, M.F. Copeland, M.L. Mole, R. Froehlich, N. Cooke & W.K. McElroy. (1984) Antagonism of chlorobenzene-induced hepatotoxicity by lindane. Pesticide Biochemistry and Physiology 21:2, pages 148-161.
Crossref
G.S. Shirwaiker & M.V. Bhatt. 1984. Advances in Heterocyclic Chemistry Volume 37. Advances in Heterocyclic Chemistry Volume 37 67 165 .
M. Ogata & Y. Shimada. (1983) Differences in urinary monochlorobenzene metabolites between rats and humans. International Archives of Occupational and Environmental Health 53:1, pages 51-57.
Crossref
HAZEL B. MATTHEWS. 1982. Metabolic Basis of Detoxication. Metabolic Basis of Detoxication 51 68 .
J.R. Kiechel. (2012) Pharmacokinetics and metabolism of guanfacine in man: a review.. British Journal of Clinical Pharmacology 10:S1.
Crossref
K. Ballschmiter & Ch. Scholz. (1980) Mikrobieller abbau von chlorierten aromaten: VI. Bildung von Dichlorphenolen und Dichlorbrenzkatechinen aus Dichlorbenzolen in mikromolarer L?sung durch Pseudomonas Sp.. Chemosphere 9:7-8, pages 457-467.
Crossref
L.F. Chasseaud. 1979. 175 274 .
Francis R. Zuleski, Arthur Loh & Frederick J. Di Carlo. (1978) Determination of Ethinyl Estradiol in Human Urine by Radiochemical GLC. Journal of Pharmaceutical Sciences 67:8, pages 1138-1141.
Crossref
. 1978. 133 163 .
Arthur Loh, Francis R. Zuleski & Frederick J. Di Carlo. (1977) Radiochemical GLC Assay for Nortriptyline in Human Plasma. Journal of Pharmaceutical Sciences 66:7, pages 1056-1058.
Crossref
Donald M. Jerina & John R. Bend. 1977. Biological Reactive Intermediates. Biological Reactive Intermediates 207 236 .
G. Sundström, O. Hutzinger & S. Safe. (1976) The metabolism of chlorobiphenyls — A review. Chemosphere 5:5, pages 267-298.
Crossref
Robert V. Smith & John P. Rosazza. (1975) Microbial Models of Mammalian Metabolism. Journal of Pharmaceutical Sciences 64:11, pages 1737-1759.
Crossref
I. C. Hsu, J. P. Van Miller & J. R. Allen. (1975) Metabolic fate of3H 2,5,2′,5′-tetrachlorobiphenyl in infant nonhuman primates. Bulletin of Environmental Contamination and Toxicology 14:2, pages 233-240.
Crossref
Robert V. Smith & John P. Rosazza. (2004) Microbial systems for study of the biotransformations of drugs. Biotechnology and Bioengineering 17:6, pages 785-814.
Crossref
H.G. Selander, D.M. Jerina & J.W. Daly. (1975) Metabolism of chlorobenzene with hepatic microsomes and solubilized cytochrome P-450 systems. Archives of Biochemistry and Biophysics 168:1, pages 309-321.
Crossref
D. M. Jerina & J. W. Daly. (1974) Arene Oxides: A New Aspect of Drug Metabolism. Science 185:4151, pages 573-582.
Crossref
Eric C. Schreiber. (1974) Metabolically Oxygenated Compounds: Formation, Conjugation, and Possible Biological Implications. Journal of Pharmaceutical Sciences 63:8, pages 1177-1190.
Crossref
Robert V. Smith & John P. Rosazza. (1974) Microbial models of mammalian metabolism. Aromatic hydroxylation. Archives of Biochemistry and Biophysics 161:2, pages 551-558.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.