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Xenobiotica
the fate of foreign compounds in biological systems
Volume 2, 1972 - Issue 5
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Research Article

The Preparation of 7-Hydroxymethylbenz[a]anthracene 5,6-Oxide and its Metabolism by Rat-liver Preparations

P. Sims Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, London, SW3 6JB, UK
Pages 469-477 | Received 26 Jul 1972, Published online: 22 Sep 2008

Citations (13)

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Read on this site (4)

StevenR. Myers. (2007) BIOALKYLATION OF BENZ(A)ANTHRACENE: IMPLICATIONS FOR CARCINOGENESIS. Polycyclic Aromatic Compounds 27:4, pages 311-337.
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J. Booth, A. Hewer, C. R. Keysell & P. Sims. (1975) Enzymic Reduction of Aromatic Hydrocarbon Epoxides by the Microsomal Fraction of Rat Liver. Xenobiotica 5:4, pages 197-203.
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L. F. Chasseaud. (1974) The Nature and Distribution of Enzymes Catalyzing the Conjugation of Glutathione with Foreign Compounds. Drug Metabolism Reviews 2:1, pages 185-220.
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Franz Oesch. (1973) Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds. Xenobiotica 3:5, pages 305-340.
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Articles from other publishers (9)

Derek R. Boyd & Donald M. Jerina. 1985. Chemistry of Heterocyclic Compounds. Chemistry of Heterocyclic Compounds 197 282 .
NOBUO NEMOTO. 1981. Polycyclic Hydrocarbons and Cancer. Polycyclic Hydrocarbons and Cancer 213 258 .
L.F. Chasseaud. 1979. 175 274 .
Lassie G. Hammock, Bruce D. Hammock & John E. Casida. (1974) Detection and analysis of epoxides with 4-(p-nitrobenzyl)-pyridine. Bulletin of Environmental Contamination and Toxicology 12:6, pages 759-764.
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D. M. Jerina & J. W. Daly. (1974) Arene Oxides: A New Aspect of Drug Metabolism. Science 185:4151, pages 573-582.
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Eric C. Schreiber. (1974) Metabolically Oxygenated Compounds: Formation, Conjugation, and Possible Biological Implications. Journal of Pharmaceutical Sciences 63:8, pages 1177-1190.
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H. Marquardt, J. E. Sodergren, P. Sims & P. L. Grover. (2006) Malignant transformation in vitro of mouse fibroblasts by 7, 12‐dimethylbenz(A)anthracene and 7‐hydroxymethylbenz(A)anthracene and by their K‐region derivatives . International Journal of Cancer 13:3, pages 304-310.
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P. Sims & P.L. Grover. 1974. 165 274 .
Gerald R. Keysell, Joan Booth, Philip L. Grover, Alan Hewer & Peter Sims. (1973) The formation of “K-region” epoxides as hepatic microsomal metabolites of 7-methylbenz[a]anthracene and 7,12-dimethylbenz[a]anthracene and their 7-hydroxymethyl derivatives. Biochemical Pharmacology 22:22, pages 2853-2867.
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