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Xenobiotica
the fate of foreign compounds in biological systems
Volume 2, 1972 - Issue 5
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Research Article

The Accumulation of Mestranol and Ethynyloestradiol Metabolites in the Organism

H. M. Bolt Institute of Toxicology, University of Tübingen, Germany
&
H. Remmer Institute of Toxicology, University of Tübingen, Germany
Pages 489-498 | Received 13 Jul 1972, Published online: 22 Sep 2008

Citations (22)

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Helmut Greim. (2004) Review of the Career of Professor Dr. Herbert Remmer. Drug Metabolism Reviews 36:3-4, pages 407-415.
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EdwardD. Helton, DanielA. Casciano, ZeldaR. Althaus & HarrisD. Plant. (1977) Metabolism of 17α‐ethynylestradiol by intact liver parenchymal cells isolated from mouse and rat. Journal of Toxicology and Environmental Health 3:5-6, pages 953-963.
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Hermann M. Bolt, Hermann Kappus & Herbert Remmer. (1973) Studies on the Metabolism of Ethynylestradiol in vitro and in vivo: The Significance of 2-Hydroxylation and the Formation of Polar Products. Xenobiotica 3:12, pages 773-785.
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Articles from other publishers (19)

Michel Oettel & Ekkehard SchillingerW. Kuhnz, H. Blode & H. Zimmermann. 1999. Estrogens and Antiestrogens II. Estrogens and Antiestrogens II 261 322 .
Helmut Greim. (1987) Laudatio to Herbert Remmer. Archives of Toxicology 60:1-3, pages 1-4.
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Peter S. Grabowski & B.Kevin Park. (1984) Drug-protein conjugates-VII. Biochemical Pharmacology 33:20, pages 3289-3294.
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J. Salmon, D. Coussediere, C. Cousty & J.P. Raynaud. (1983) Pharmacokinetics and metabolism of moxestrol in animals—rat, dog and monkey. Journal of Steroid Biochemistry 19:2, pages 1223-1234.
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Humeida A. El-Obeid & Abdullah A. Al-Badr. 1982. 375 406 .
Nello J. Spiteri, Robert F. Drewett & Una Padel. (1980) Behavioral effects of ethynyl estrogens in the female rat. Physiology & Behavior 25:3, pages 409-415.
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M. H. Briggs. 1980. Clinical Pharmacology & Therapeutics. Clinical Pharmacology & Therapeutics 493 518 .
Betty L. Warren & Gail D. Bellward. (2016) Benign Liver Tumors and Oral Contraceptive Therapy. Drug Intelligence & Clinical Pharmacy 13:11, pages 680-689.
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Giorgio Stramentinoli, Maria Gualano, Paola Rovagnati & Carlo Di Padova. (1979) Influence of s-adenosyl-l-methionine on irreversible binding of ethynylestradiol to rat liver microsomes, and its implication in bile secretion. Biochemical Pharmacology 28:7, pages 981-984.
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H.M. Bolt. (1979) Metabolism of estrogens—natural and synthetic. Pharmacology & Therapeutics 4:1, pages 155-181.
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Michael Schwenk, Victor López Del Pino & Hermann M. Bolt. (1979) The kinetics of hepatocellular transport and metabolism of estrogens (comparison between estrone sulfate, estrone and ethinylestradiol). Journal of Steroid Biochemistry 10:1, pages 37-41.
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Volker Ullrich. 1979. Blood Vessels. Blood Vessels 67 104 .
Melvin J. Fregly & Terry N. Thrasher. (1978) Attenuation of angiotensin-induced water intake in estrogen-treated rats. Pharmacology Biochemistry and Behavior 9:4, pages 509-514.
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David Brewster, Robin S. Jones & Andrew M. Symons. (1977) Effects of neomycin on the biliary excretion and enterohepatic circulation of mestranol and 17β-oestradiol. Biochemical Pharmacology 26:10, pages 943-946.
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Edward D. Helton & Joseph W. Goldzieher. (1977) The pharmacokinetics of ethynyl estrogens. A review. Contraception 15:3, pages 255-284.
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Edward L. Docks & Gopal Krishna. (1975) Covalent binding of trans-stilbene to rat liver microsomes. Biochemical Pharmacology 24:21, pages 1965-1969.
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H. M. Bolt & W. H. Bolt. (1974) Pharmacokinetics of mestranol in man in relation to its oestrogenic activity. European Journal of Clinical Pharmacology 7:4, pages 295-305.
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H. Kappus, H.M. Bolt & H. Remmer. (1973) Irreversible protein binding of metabolites of ethynylestradiol in vivo and in vitro. Steroids 22:2, pages 203-225.
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H. Kappus, H.M. Bolt & H. Remmer. (1973) Affinity of ethynyl-estradiol and mestranol for the uterine estrogen receptor and for the microsomal mixed function oxidase of the liver. Journal of Steroid Biochemistry 4:2, pages 121-128.
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