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Xenobiotica
the fate of foreign compounds in biological systems
Volume 2, 1972 - Issue 6
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Research Article

Piperonyl Butoxide Metabolism by Cytochrome P-450: Factors Affecting the Formation and Disappearance of the Metabolite-Cytochrome P-450 Complex

Michael R. Franklin Department of Biochemistry, University of Texas, Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, Texas, 75235, USA; Department of Biopharmaceutical Sciences, College of Pharmacy, University of Utah, Salt Lake City, Utah, 84112, USA
Pages 517-527 | Received 11 Jul 1972, Published online: 22 Sep 2008

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Michael Murray. (2012) Toxicological Actions of Plant-Derived and Anthropogenic Methylenedioxyphenyl-Substituted Chemicals in Mammals and Insects. Journal of Toxicology and Environmental Health, Part B 15:6, pages 365-395.
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Michael R. Franklin. (1974) Complexes of Metabolites of Amphetamines with Hepatic Cytochrome P-450. Xenobiotica 4:3, pages 133-142.
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Articles from other publishers (20)

Yanjun Hong, Yvonne Mei Fen Chia, Ray Hng Yeo, Gopalakrishnan Venkatesan, Siew Kwan Koh, Christina Li Lin Chai, Lei Zhou, Pipin Kojodjojo & Eric Chun Yong Chan. (2016) Inactivation of Human Cytochrome P450 3A4 and 3A5 by Dronedarone and N -Desbutyl Dronedarone . Molecular Pharmacology 89:1, pages 1-13.
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Sumiko Tayama. (1996) Cytogenetic effects of piperonyl butoxide and safrole in CHO-K1 cells. Mutation Research/Genetic Toxicology 368:3-4, pages 249-260.
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B. Ganesh Bhat & N. Chandrasekhara. (1987) Interaction of piperine with rat liver microsomes. Toxicology 44:1, pages 91-98.
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Zhiqiang Liu & Michael R. Franklin. (1984) Cytochrome P-450 metabolic — intermediate complex formation from p-aminobenzoic acid esters and other arylamines. European Journal of Drug Metabolism and Pharmacokinetics 9:2, pages 155-159.
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H G Jonen, J Werringloer, R A Prough & R W Estabrook. (1982) The reaction of phenylhydrazine with microsomal cytochrome P-450. Catalysis of heme modification.. Journal of Biological Chemistry 257:8, pages 4404-4411.
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Kuo-Mei Chang, C.F. Wilkinson & Krystyna Hetnarski. (1981) Spectral and inhibitory interactions of methylenedioxyphenyl compounds with southern armyworm (Spodoptera eridania) midgut microsomes. Pesticide Biochemistry and Physiology 15:1, pages 32-42.
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Yu Loh-Sheng, Christopher F. Wilkinson & Marion W. Anders. (1980) Generation of carbon monoxide during the microsomal metabolism of methylenedioxyphenyl compounds. Biochemical Pharmacology 29:8, pages 1113-1122.
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Maurice Dickins, Clifford R. Elcombe, Stephen J. Moloney, Karl J. Netter & James W. Bridges. (1979) Further studies on the dissociation of the isosafrole metabolite-cytochrome p-450 complex. Biochemical Pharmacology 28:2, pages 231-238.
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Thomas J. Haley. (1978) Piperonyl butoxide, α[2-(2-butoxyethoxy)ethoxy]-4,5-methylenedioxy-2-propyltoluene: A review of the literature. Ecotoxicology and Environmental Safety 2:1, pages 9-31.
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Michael R. Franklin. (1977) Inhibition of mixed-function oxidations by substrates forming reduced cytochrome P-450 metabolic-intermediate complexes. Pharmacology & Therapeutics. Part A: Chemotherapy, Toxicology and Metabolic Inhibitors 2:1, pages 227-245.
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Dennis V. Parke. 1977. Principles of Surgical Oncology. Principles of Surgical Oncology 113 156 .
Michael R. Franklin. (1976) A new class of inhibitory cytochrome P-450 complexes formed during metabolism: A comparison with amphetamine and SKF 525-A type complexes. Chemico-Biological Interactions 14:3-4, pages 337-346.
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Clifford R. Elcombe, James W. Bridges & Robert H. Nimmo-Smith. (1976) Substrate-elicited dissociation of a complex of cytochrome P-450 with a methylenedioxyphenyl metabolite. Biochemical and Biophysical Research Communications 71:4, pages 915-919.
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M R Franklin. (1976) Methylenedioxyphenyl insecticide synergists as potential human health hazards.. Environmental Health Perspectives 14, pages 29-37.
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Ernest Hodgson & Laurence G. Tate. 1976. Insecticide Biochemistry and Physiology. Insecticide Biochemistry and Physiology 115 148 .
Clifford R. Elcombe, James W. Bridges, Timothy J.B. Gray, Robert H. Nimmo-Smith & Karl J. Netter. (1975) Studies on the interaction of safrole with rat hepatic microsomes. Biochemical Pharmacology 24:15, pages 1427-1433.
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Jurgen Werringloer & Ronald W. Estabrook. (1975) Heterogeneity of liver microsomal cytochrome P-450: The spectral characterization of reactants with reduced cytochrome P-450. Archives of Biochemistry and Biophysics 167:1, pages 270-286.
Crossref
Dennis V. Parke. 1975. Enzyme Induction. Enzyme Induction 207 271 .
J.E. Tomaszewski, D.M. Jerina & J.W. Daly. 1974. Annual Reports in Medicinal Chemistry Volume 9. Annual Reports in Medicinal Chemistry Volume 9 290 299 .
Ernest Hodgson. 1974. Survival in Toxic Environments. Survival in Toxic Environments 213 260 .

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