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Xenobiotica
the fate of foreign compounds in biological systems
Volume 3, 1973 - Issue 2
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Research Article

Identification of Doxapram Metabolites using High Pressure Ion Exchange Chromatography and Mass Spectroscopy

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Pages 73-83 | Received 07 Aug 1972, Published online: 14 Oct 2008

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R. T. Coutts, F. Jamali, F. Malek, A. Peliowski & N. N. Finer. (1991) Urinary metabolites of doxapram in premature neonates. Xenobiotica 21:10, pages 1407-1418.
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J.V. Aranda, K. Beharry, J. Rex, N. Linder & P. Blanchard. (1988) High Pressure Liquid Chromatographic Microassay for Simultaneous Measurement of Doxapram and its Metabolites in Premature Newborn Infants. Journal of Liquid Chromatography 11:14, pages 2983-2991.
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H. Kamimura, Y. Enjoji, H. Sasaki, R. Kawai, H. Kaniwa, K. Niigata & S. Kageyama. (1987) Disposition and metabolism of indeloxazine hydrochloride, a cerebral activator, in rats. Xenobiotica 17:6, pages 645-658.
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A. Assandri, A. Perazzi, E. Bellasio, R. Ciabatti, G. Tarzia, P. Ferrari, A. Ripamonti, G. Tuan & L. F. Zerilli. (1985) Metabolic pathways of the anti-hypertensive agent, N-(2,5-dimethyl-1H-pyrrol-1-yl)-6-(4-morpholinyl)-3-pyridazinamine hydrochloride. II: Studies in the dog. Xenobiotica 15:12, pages 1089-1102.
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H. Davi, P. Dupont, J. P. Jeanniot, R. Roncucci & W. Cautreels. (1981) The biotransformation of [14C]minaprine in man and five animal species. Xenobiotica 11:11, pages 735-747.
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N. Kucharczyk, J. T. Yang, K. H. Valia, F. J. Stiefel & R. D. Sofia. (1979) Metabolites of 2-(3-Trifluoromethylphenyl)Tetrahydro-1,4-Oxazine (Cerm 1841) in Rats and Dogs. Xenobiotica 9:11, pages 703-711.
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Bernard Testa & Peter Jenner. (1978) Novel Drug Metabolites Produced by Functionalization Reactions: Chemistry and Toxicology. Drug Metabolism Reviews 7:2, pages 325-369.
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Lennox B. Turnbull, Lina Teng, John M. Kinzie, Jefferson E. Pitts, Franklin M. Pinchbeck & Robert B. Bruce. (1978) Excretion and Biotransformation of Carboxymethyl-cysteine in Rat, Dog, Monkey and Man. Xenobiotica 8:10, pages 621-628.
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Kiyoshi Tatsumi, Shigeyuki Kitamura, Hidetoshi Yoshimura, Satoru Tanaka, Kazunori Hashimoto & Toshiji Igarashi. (1975) The Metabolism of Phenyl o-(2-N-morpholinoethoxy)-phenyl Ether Hydrochloride in the Rabbit and Rat. Xenobiotica 5:6, pages 377-388.
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Articles from other publishers (14)

R. A. SAMS, R. L. DETRA & W. W. MUIR III. (2010) Pharmacokinetics and metabolism of intravenous doxapram in horses. Equine Veterinary Journal 24:S11, pages 45-51.
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Herbert Oelschläger & Wolfgang Schmidt. (2006) Die N ‐Oxidation ‐ ein Zwischenschritt bei der Biosynthese von Lactamen aus tertiären Cycloalkylaminen . Archiv der Pharmazie 325:1, pages 41-45.
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J.V. Aranda, J.M. Lopes, P. Blanchard, F. Eyal & G. Alpan. 1991. Neonatal Clinical Pharmacology and Therapeutics. Neonatal Clinical Pharmacology and Therapeutics 95 115 .
Günter SeyffartGünter Seyffart. 1991. Drug Dosage in Renal Insufficiency. Drug Dosage in Renal Insufficiency 172 217 .
John W. Gorrod, Catherine M. C. Whittlesea & Siu Ping Lam. 1991. Biological Reactive Intermediates IV. Biological Reactive Intermediates IV 657 664 .
M Mattila & I Larma. (2012) A simple method for the administration of doxapram.. British Journal of Clinical Pharmacology 23:3, pages 371-372.
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G.A. Torok-Both, R.T. Coutts, F. Jamali, F.M. Pasutto & K.J. Barrington. (1985) Sensitive nitrogen?phosphorus capillary gas chromatographic assay for doxapram in premature infants. Journal of Chromatography B: Biomedical Sciences and Applications 344, pages 372-377.
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H. Greg Thomas & Peter C. Ruenitz. (2009) Mechanistic aspects of oxidation of N ‐substituted 5 H ‐dibenz[ c,e ]azepines by aldehyde oxidase . Journal of Heterocyclic Chemistry 21:4, pages 1057-1062.
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Helen Nichol, John Vine, Jack Thomas & R.George Moore. (1980) Quantitation of doxapram in blood, plasma and urine. Journal of Chromatography B: Biomedical Sciences and Applications 182:2, pages 191-200.
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G. Huizing, A. H. Beckett & J. Segura. (1979) Identification of a lactam by mass spectrometry and proton magnetic resonance spectroscopy. Pharmaceutisch weekblad 1:1, pages 436-443.
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RH Robson & LF Prescott. (2012) A pharmacokinetic study of doxapram in patients and volunteers.. British Journal of Clinical Pharmacology 7:1, pages 81-87.
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Herbert A. H. Oelschläger, David J. Temple & Julia Iglesias‐Meier. (2006) Über den Mechanismus der oxidativen Abspaltung des Morpholins aus dem Lokalanästhetikum Fomocain. Archiv der Pharmazie 310:7, pages 579-587.
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G. Spiteller & G. Remberg. (1974) Arzneimittelstoffwechseluntersuchungen mit der Massenspektrometrie. Die Naturwissenschaften 61:11, pages 491-499.
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David R. Hawkins, William H. Down, Leslie F. Chasseaud & John D. Lewis. (2006) The metabolic fate of tridemorph in rats. Pesticide Science 5:5, pages 535-542.
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