Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 3, 1973 - Issue 2
406
Views
86
CrossRef citations to date
0
Altmetric
Research Article

The Metabolism of Salbutamol in Man

, , &
Pages 113-120 | Received 10 Oct 1972, Published online: 14 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Valentin T. Popa. (1984) Clinical Pharmacology of Adrenergic Drugs. Journal of Asthma 21:3, pages 183-207.
Read now
J. A. Bell, A. Bradbury, L. E. Martin & R. J. N. Tanner. (1981) Applications of high-voltage paper electrophoresis for the characterization of drug metabolites. Xenobiotica 11:12, pages 841-847.
Read now
T. Shimizu, H. Mori, E. Tabusa, S. Morita, G. Miyamoto, Y. Yasuda & K. Nakagawa. (1978) The Metabolism of a Bronchodilator Procaterol HCl in the Rat in vitro and in vivo. Xenobiotica 8:6, pages 349-358.
Read now
Peter Jenner & Bernard Testa. (1978) Novel Pathways in Drug Metabolism. Xenobiotica 8:1, pages 1-25.
Read now
Milo Gibaldi & Donald Perrier. (1975) Route of Administration and Drug Disposition. Drug Metabolism Reviews 3:1, pages 185-199.
Read now

Articles from other publishers (81)

Mona A. Abdelrahman, Ahmed A. Elberry, Raghda R. S. Hussein & Mohamed E. Abdelrahim. (2019) Effect of Holding Chamber as an Add-on Device on Aerosol Delivery and Fugitive Aerosol from Different Jet Nebulizers. Journal of Pharmaceutical Innovation 15:1, pages 73-79.
Crossref
Wallace B. WeeKitty LeungAllan L. Coates. (2013) Modeling Breath-Enhanced Jet Nebulizers to Estimate Pulmonary Drug Deposition. Journal of Aerosol Medicine and Pulmonary Drug Delivery 26:6, pages 387-396.
Crossref
Liang Li. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 4 .
Eric Sands. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Eric Sands. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Ping Li. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Alexander V. LyubimovBennett Ma & Michael L. Schrag. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 29 .
Donald G. BarcelouxJames Rhee & Timothy Erickson. 2012. Medical Toxicology of Drug Abuse. Medical Toxicology of Drug Abuse 295 305 .
K F Ilett, C T Dollery & D S Davies. (1980) Isoprenaline conjugation—a “true first-pass effect” in the dog intestine. Journal of Pharmacy and Pharmacology 32:1, pages 362-362.
Crossref
S.H.R.A. Mazhar & H. Chrystyn. (2009) New HPLC assay for urinary salbutamol concentrations in samples collected post-inhalation. Journal of Pharmaceutical and Biomedical Analysis 50:2, pages 175-182.
Crossref
Benjamin C Sporer, Andrew W Sheel, Jack Taunton, Jim L Rupert & Donald C McKenzie. (2008) Inhaled Salbutamol and Doping Control: Effects of Dose on Urine Concentrations. Clinical Journal of Sport Medicine 18:3, pages 282-285.
Crossref
Gian Maria Pacifici. 2005. Human Cytosolic Sulfotransferases. Human Cytosolic Sulfotransferases 157 177 .
Eva Bondesson, Thomas Bengtsson, Lars Borgström, Lars-Erik Nilsson, Kristina Norrgren, Eva Trofast & Per Wollmer. (2003) Planar gamma scintigraphy—points to consider when quantifying pulmonary dry powder aerosol deposition. International Journal of Pharmaceutics 258:1-2, pages 227-240.
Crossref
Eva Bondesson, Thomas Bengtsson, Lars Borgstr?m, Lars-Erik Nilsson, Kristina Norrgren, Eva Trofast & Per Wollmer. (2003) Planar gamma scintigraphy?points to consider when quantifying pulmonary dry powder aerosol deposition. International Journal of Pharmaceutics 251:1-2, pages 33-47.
Crossref
K Walton, J.L Dorne & A.G Renwick. (2001) Uncertainty factors for chemical risk assessment: interspecies differences in glucuronidation. Food and Chemical Toxicology 39:12, pages 1175-1190.
Crossref
David W. Boulton & J. Paul Fawcett. (2001) The Pharmacokinetics of Levosalbutamol. Clinical Pharmacokinetics 40:1, pages 23-40.
Crossref
Fiona J. CouperOlaf H. Drummer. (1999) Postmortem Stability and Interpretation of ? 2 -Agonist Concentrations . Journal of Forensic Sciences 44:3, pages 14503J.
Crossref
Raviraj S. Pillai, Donovan B. Yeates, Irving F. Miller & Anthony J. Hickey. (1998) Controlled dissolution from wax-coated aerosol particles in canine lungs. Journal of Applied Physiology 84:2, pages 717-725.
Crossref
Aldo Polettini. (1996) Bioanalysis of ?2-agonists by hyphenated chromatographic and mass spectrometric techniques. Journal of Chromatography B: Biomedical Sciences and Applications 687:1, pages 27-42.
Crossref
David W. Boulton & J. Paul Fawcett. (1996) Enantioselective disposition of albuterol in humans. Clinical Reviews in Allergy & Immunology 14:1, pages 115-138.
Crossref
Thomas Walle, E. Alison Eaton, U. Kristina Walle & Gene R. Pesola. (1996) Stereoselective metabolism ofRS-albuterol in humans. Clinical Reviews in Allergy & Immunology 14:1, pages 101-113.
Crossref
D. W. BOULTON & J. P. FAWCETT. (1996) Enantioselective disposition of salbutamol in man following oral and intravenous administration. British Journal of Clinical Pharmacology 41:1, pages 35-40.
Crossref
R Demnati, MC Michoud, A Jeanneret‐Grosjean, H Ong & P Du Souich. (2012) Plasma concentrations and effects of salbutamol administered orally to patients with cystic fibrosis.. British Journal of Clinical Pharmacology 40:4, pages 319-324.
Crossref
David W. Boulton & J. Paul Fawcett. (1995) Determination of salbutamol enantiomers in human plasma and urine by chiral high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 672:1, pages 103-109.
Crossref
R.S Pillai, D.B Yeates, I.F Miller & A.J Hickey. (1994) Controlled release from condensation coated respirable aerosol particles. Journal of Aerosol Science 25:3, pages 461-477.
Crossref
Charles H. Vite & Roger W. Gfeller. (2007) Suspected Albuterol Intoxication In A Dog. Journal of Veterinary Emergency and Critical Care 4:1, pages 7-13.
Crossref
Margitta Albinus, Gudrun Amschler, Uwe Amschler, Erwin von Angerer, Wolfgang Barthel, Andrea Bauer, Kurt Bauer, Jürgen Beckmann, Winfried Beil, Jürgen Beitz, Petra Berscht, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bracher, Helmut Bräunlich, Kerstin Brinkmann, Franz von Bruchhausen, Kay Brune, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Siegfried Ebel, Kurt Eger, Peter Emig, Thomas Erker, Maria S. Fernandez-Alfonso, August Wilhelm Frahm, Margarete Frahm, Klaus-Jürgen Freundt, Detlef Geffken, Ulrich Geis, Erika Glusa, Berthold Göber, Jochen Gödicke, Margarete Goppelt-Strübe, Wilhelm Gössling, Annette Graul, Sibylle Greiner, Adolf Grisk, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Axel Haberkorn, Eberhard Hackenthal, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Andreas Hensel, Sibylle Hoedt-Schmidt, Hermann Hoffmann, Ute Hoffmann-Schollmayer, Ulrike Holzgrabe, Martin Hug, Wolfgang Ibrom, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Nasser Khudeir, Werner Kiefer, Doris Kleinsorge, Christoph Klett, Stephanie Klett, Martin Klingmüller, H.-P. Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, Gottfried Kreutz, Reinhard Kroker, Dorothea Landsiedel-Maier, Jochen Lehmann, Marion Sylvia Lehner, Stefan Leiner, Hans Löwe, Johannes Mann, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Hans-Jürgen Mest, Frank Peter Meyer, J. Mollière, Rudolf Morgenstern, Wolfgang Morick, Joachim Mössner, Christa Müller, Daniel Müller, Klaus Müller, Walter Müller, Alexander Mülsch, Tilo Netzer, Michael Neugebauer, Ulf Niemeyer, Peter Nuhn, Bernd Nürnberg, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Martina Pickert, Andreas Pies, Klaus Pietrzik, Detlef Preiss, Helmut Priewer, Olaf Queckenberg, Eberhard Reimann, Jörg Remien, Rainer Rettig, Andreas Reymann, Joachim Richter, Hans Rommelspacher, Ulrich Rose, Gerhard Rücker, Klaus Schaefer, Helmut Schlager, Werner Schleicher, Hildegard Schleinitz, Wolfgang Schlichter, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Helmut Schwilden, Monika Serke, Gisela Skopp, Marcus Spohn, Ralf Stahlmann, Johannes-Peter Stasch, Christian Steffen, Jürgen Steinmeyer, Karl-Heinz Surborg, Ulf Sürig, Istvan Szelenyi, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Franz-Josef Volk, Heinz Walther, Horst Weber, Judith Wede, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Hilke Winterhoff, Reinhold Wintersteiger, Frauke Woltmann, Diaa Youssef & A. Ziegler. 1994. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis 545 764 .
Guy Degand, Anne Bernes-Duyckaerts, Philippe Delahaut & Guy Maghuin-Rogister. (1993) Determination of ?-agonists in urine by an enzyme immunoassay based on the use of an anti-salbutamol antiserum. Analytica Chimica Acta 275:1-2, pages 241-247.
Crossref
J.B.D. Palmer, G.L. Shepherd, A.T. Cifelli, PaulS. Myles & AnthonyM. Weeks. (1992) Muscling in on salbutamol. The Lancet 340:8832, pages 1407.
Crossref
Sylvie Perreault, Huy Ong & Patrick du Souich. (1992) Salbutamol disposition and dynamics in conscious rabbits: Influence of the route of administration and of the dose. Journal of Pharmacokinetics and Biopharmaceutics 20:5, pages 461-476.
Crossref
Günter SeyffartGünter Seyffart. 1991. Drug Dosage in Renal Insufficiency. Drug Dosage in Renal Insufficiency 527 557 .
R. G. Goldie, J. W. Paterson & K. M. Lulich. 1991. Pharmacology of Asthma. Pharmacology of Asthma 167 205 .
Roy G. Goldie, James W. Paterson & Karmelo M. Lulich. (1990) Adrenoceptors in airway smooth muscle. Pharmacology & Therapeutics 48:3, pages 295-322.
Crossref
M. E. Conolly. 1989. Catecholamines II. Catecholamines II 357 389 .
S. S. Chua, S. I. Benrimoj & E. J. Triggs. (2006) Pharmacokinetics of non‐prescription sympathomimetic agents. Biopharmaceutics & Drug Disposition 10:1, pages 1-14.
Crossref
B.R.C. O'Driscoll, S.P. Ruffles, Jon G. Ayres & G.M. Cochrane. (1988) Long term treatment of severe asthma with subcutaneous terbutaline. British Journal of Diseases of the Chest 82, pages 360-367.
Crossref
Mark L. Powell, Miryam Weisberger, Yvonne Dowdy, Richard Gural, Samson Symchowicz & James E. Patrick. (2006) Comparative steady state bioavailability of conventional and controlled‐release formulations of albuterol. Biopharmaceutics & Drug Disposition 8:5, pages 461-468.
Crossref
MJ Hutchings, JD Paull, E Wilson‐Evered & DJ Morgan. (2012) Pharmacokinetics and metabolism of salbutamol in premature labour.. British Journal of Clinical Pharmacology 24:1, pages 69-75.
Crossref
Yok K. Tan & Steven J. Soldin. (1987) Analysis of salbutamol enantiomers in human urine by chiral high-performance liquid chromatography and preliminary studies related to the stereoselective disposition kinetics in man. Journal of Chromatography B: Biomedical Sciences and Applications 422, pages 187-195.
Crossref
M. L. Powell, M. Chung, M. Weisberger, R. Gural, E. Radwanski, S. Symchowicz & J. E. Patrick. (2013) Multiple‐Dose Albuterol Kinetics. The Journal of Clinical Pharmacology 26:8, pages 643-646.
Crossref
DJ Morgan, JD Paull, BH Richmond, E Wilson‐Evered & SP Ziccone. (2012) Pharmacokinetics of intravenous and oral salbutamol and its sulphate conjugate.. British Journal of Clinical Pharmacology 22:5, pages 587-593.
Crossref
Valentin Popa. (1986) Beta-Adrenergic Drugs. Clinics in Chest Medicine 7:3, pages 313-329.
Crossref
Mark L. Powell, Miryam Weisberger, Richard Gural, Menger Chung, James E. Patrick, Elaine Radwanski & Samson S. Symchowicz. (1985) Comparative Bioavailability and Pharmacokinetics of Three Formulations of Albuterol. Journal of Pharmaceutical Sciences 74:2, pages 217-219.
Crossref
Normand Beaulieu, Claude Charette, Jack C.K. Loo, Nicole Jordan & Iain J. McGilveray. (1985) Salbutamol radioimmunoassay: Synthesis and properties of the benzylic succinate of salbutamol. Journal of Pharmaceutical and Biomedical Analysis 3:6, pages 575-579.
Crossref
Richard C. Ahrens & Gary D. Smith. (2012) Albuterol: An Adrenergic Agent for Use in the Treatment of Asthma Pharmacology, Pharmacokinetics and Clinical Use. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 4:3, pages 105-120.
Crossref
Nahoko Kurosawa, Seiji Morishima, Eiji Owada & Keiji Ito. (1984) Reversed-phase high-performance liquid chromatographic determination of salbutamol in rabbit plasma. Journal of Chromatography B: Biomedical Sciences and Applications 305, pages 485-488.
Crossref
Kunikazu Yokoi, Kiyoshi Murase & Yuichi Shiobara. (1983) The development of a radioimmunoassay for formoterol. Life Sciences 33:17, pages 1665-1672.
Crossref
Miryam Weisberger, James E. Patrick & Mark L. Powell. (1983) Quantitative analysis of albuterol in human plasma by combined gas chromatography chemical ionization mass spectrometry. Biological Mass Spectrometry 10:10, pages 556-558.
Crossref
C. Warren Bierman. (1983) Adrenergic drugs. Clinical Reviews in Allergy 1:1.
Crossref
Theodor H. Lippert. 1983. Clinical Pharmacology in Obstetrics. Clinical Pharmacology in Obstetrics 182 218 .
J. Morley, W. Paul & G. S. Basran. 1983. Proceedings of Invited Symposia. Proceedings of Invited Symposia 501 505 .
Kenneth F. Ilett & Donald S. Davies. 1982. Presystemic Drug Elimination. Presystemic Drug Elimination 43 65 .
Burt W. Finkelstein, Eric A. Jackson & Alex A. Cardoni. (2016) Ritodrine (Yutopar?, Merrell Dow Pharmaceuticals Inc.). Drug Intelligence & Clinical Pharmacy 15:6, pages 425-433.
Crossref
J. Wager, N. O. Lunell, M. Nadal & J. Östman. (2011) GLUCOSE TOLERANCE FOLLOWING ORAL SALBUTAMOL TREATMENT IN LATE PREGNANCY. Acta Obstetricia et Gynecologica Scandinavica 60:3, pages 291-294.
Crossref
Kugako Matsumura, Osamu Kubo, Toshiko Sakashita, Yumiko Adachi, Hideo Kato, Keizo Watanabe & Masaaki Hirobe. (1981) Quantitative determination of tulobuterol and its metabolites in human urine by mass fragmentography. Journal of Chromatography B: Biomedical Sciences and Applications 222:1, pages 53-60.
Crossref
HilaryJ. Andrews & M.J. Dann. (1981) MYCOPLASMA AND POST PARTUM FEVER. The Lancet 317:8210, pages 43.
Crossref
P.G. Brock & M. Roach. (1981) ANTITUBERCULOUS DRUGS IN PREGNANCY. The Lancet 317:8210, pages 43.
Crossref
G.J Addis. (1981) LONG-TERM SALBUTAMOL INFUSION TO PREVENT PREMATURE LABOUR. The Lancet 317:8210, pages 42-43.
Crossref
Hassan Y. Aboul-Enein, Abdullah A. Al-Badr & S.E. Ibrahim. 1981. 665 689 .
B. N. C. Prichard, C. W. I. Owens & J. Tuckman. 1981. Adrenergic Activators and Inhibitors. Adrenergic Activators and Inhibitors 559 697 .
PJ Phillips, AE Vedig, PL Jones, MG Chapman, M. Collins, JB Edwards, TC Smeaton & BM Duncan. (2012) Metabolic and cardiovascular side effects of the beta 2‐adrenoceptor agonists salbutamol and rimiterol.. British Journal of Clinical Pharmacology 9:5, pages 483-491.
Crossref
R. Gandar, L. W. de Zoeten & J. B. van der Schoot. (1980) Serum level of ritodrine in man. European Journal of Clinical Pharmacology 17:2, pages 117-122.
Crossref
John A. Crowhurst. (2019) Salbutamol, Obstetrics and Anaesthesia: A Review and Case Discussion. Anaesthesia and Intensive Care 8:1, pages 39-43.
Crossref
E. A. Stemmann & G. E. Wolff. 1980. Monatsschrift Kinderheilkunde. Monatsschrift Kinderheilkunde 89 92 .
S.A. Kempson & G.V. Marinetti. (1979) Distribution of 3H-dihydroalprenolol and 3H-dihydroergocryptine in tissues of rat and frog. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 63:1, pages 177-181.
Crossref
Susumu Iwasa, Koichi Kondo, Tsutomu Miya & Kazumi Takeda. (1978) Enzyme immunoassay of a ?-adrenergic agent using ?-galactosidase as label. Immunopharmacology 1:1, pages 3-12.
Crossref
Gary B. Hastwell, Christopher P. Halloway & Thomas L. O. Taylor. (1978) A STUDY OF 208 PATIENTS IN PREMATURE LABOUR TREATED WITH ORALLY ADMINISTERED SALBUTAMOL. Medical Journal of Australia 1:9, pages 465-469.
Crossref
. 1978. 21 44 .
N. O. Lunell, J. Wager, B. B. Fredholm & B. Persson. (1978) Metabolic effects of oral salbutamol in late pregnancy. European Journal of Clinical Pharmacology 14:2, pages 95-99.
Crossref
ME Pickup, AJ Johnson, CS May, JW Paterson & MP Harrison. (2012) The absorption and elimination of ICI 74,917 in man.. British Journal of Clinical Pharmacology 4:3, pages 357-366.
Crossref
J.G. Leferink, I. Wagemaker-Engels, R.A.A. Maes, H. Lamont, R. Pauwels & M. van der Straeten. (1977) Quantitative analysis of terbutaline in serum and urine at therapeutic levels using gas chromatography—mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 143:3, pages 299-305.
Crossref
Christopher W. Norwood, G. Joseph Poole & Dixon Moody. (1976) Treatment of experimental delayed cerebral arterial spasm with a beta2-adrenergic stimulator and a phosphodiesterase inhibitor. Journal of Neurosurgery 45:5, pages 491-497.
Crossref
GILLIAN M. SHENFIELD, MARION E. EVANS & J.W. PATERSON. (1976) ABSORPTION OF DRUGS BY THE LUNG. British Journal of Clinical Pharmacology 3:4, pages 583-589.
Crossref
L. E. Martin, Janet Rees & R. J. N. Tanner. (1976) Quantitative determination of salbutamol in plasma, as either its trimethylsilyl ort-butyldimethylsilyl ether, using a stable isotope multiple ion recording technique. Biological Mass Spectrometry 3:4, pages 184-190.
Crossref
Peter Schuster, Eberhard Gabriel, Bernd Kufferle & Manfred Karobath. (1976) REVERSAL BY PHYSOSTIGMINE OF CLOZAPINE-INDUCED DELIRIUM. The Lancet 307:7949, pages 37-38.
Crossref
D.M. Harris. (1976) SALBUTAMOL AEROSOL IN PREMATURE LABOUR. The Lancet 307:7949, pages 37.
Crossref
Alain Junod. (1976) Uptake, release and metabolism of drugs in the lungs. Pharmacology & Therapeutics. Part B: General and Systematic Pharmacology 2:3, pages 511-521.
Crossref
R.T. Brittain, C.M. Dean & D. Jack. (1976) Sympathomimetic bronchodilator drugs. Pharmacology & Therapeutics. Part B: General and Systematic Pharmacology 2:3, pages 423-462.
Crossref
Milo Gibaldi, James E. Axelson & Walter D. Conway. (1975) Disposition of N,N-Bis(phenylcarbamoylmethyl)dimethyl Ammonium Chloride in the Rat: An Interesting Example of First-Pass Metabolism. Journal of Pharmaceutical Sciences 64:2, pages 359-360.
Crossref
GILLIAN M. SHENFIELD, MARION E. EVANS & J.W. PATERSON. (1974) THE EFFECT OF DIFFERENT NEBULIZERS WITH AND WITHOUT INTERMITTENT POSITIVE PRESSURE BREATHING ON THE ABSORPTION AND METABOLISM OF SALBUTAMOL. British Journal of Clinical Pharmacology 1:4, pages 295-300.
Crossref
. (1974) Proceedings of The Thoracic Society. Thorax 29:2, pages 265-270.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.